Abstract

An attempt has been made to design suitable niosome-encapsulated drug delivery system for ciprofloxacin and norfloxacin. Encapsulation of ciprofloxacin and norfloxacin in niosomes was investigated and the nasal and intestinal absorption of the products studied. More than 80% of the drugs were successfully encapsulated to give products with sustained release characteristics. Encapsulation in niosomes also improved the stability of the antibacterial compounds. Although the systemic availability of these niosome-encapsulated antibacterial compounds was not increased after nasal administration, intestinal absorption was significantly higher in comparison with that of plain inclusion complexes.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Volume49
Issue number2
Publication statusPublished - 02-1997

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Norfloxacin
Ciprofloxacin
Liposomes
Intestinal Absorption
Intranasal Administration
Drug Delivery Systems
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

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abstract = "An attempt has been made to design suitable niosome-encapsulated drug delivery system for ciprofloxacin and norfloxacin. Encapsulation of ciprofloxacin and norfloxacin in niosomes was investigated and the nasal and intestinal absorption of the products studied. More than 80{\%} of the drugs were successfully encapsulated to give products with sustained release characteristics. Encapsulation in niosomes also improved the stability of the antibacterial compounds. Although the systemic availability of these niosome-encapsulated antibacterial compounds was not increased after nasal administration, intestinal absorption was significantly higher in comparison with that of plain inclusion complexes.",
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Absorption of ciprofloxacin and norfloxacin when administered as niosome-encapsulated inclusion complexes. / D'Souza, S. A.; Ray, J.; Pandey, S.; Udupa, N.

In: Journal of Pharmacy and Pharmacology, Vol. 49, No. 2, 02.1997, p. 145-149.

Research output: Contribution to journalArticle

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