Acanthosis nigricansin PCOS patients and its relation with type 2 diabetes mellitus and body mass at a tertiary care hospital in Southern India

G. Shivaprakash, A. Basu, Ashwin Kamath, Pallavi Shivaprakash, Prabha Adhikari, U. P. Rathnakar, H. N. Gopalakrishna, Jagadish Rao Padubidri

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Acanthosis nigricansis was viewed recently as a possible marker of an increased risk for diabetes. Acanthosis Nigricans (AN) can help in identifying the patients with an increased risk for Type 2 Diabetes Mellitus (T2DM) among Polycystic Ovary Syndrome (PCOS) cases. Hence, this study was carried to know the prevalence of AN in PCOS and its correlation with diabetes mellitus and the body mass. Methods: A prospective, longitudinal study in the patients with PCOS, who attended the Department of Medicine, Kasturba Medical College [KMC] Hospital, Attavar, Mangalore, Karnatka, India between December 2008 to April 2010, was carried out. A total of 119 patients with PCOS were included in the study. A complete history, along with the demographic data of the patients who were aged between 15-35 years, were considered for the analysis. Results: AN was observed in 56% of the PCOS patients. The Body Mass Index (BMI) and the waist circumference were significantly higher in the PCOS patients with AN, as compared to those without AN. Among the 119 PCOS patients, 77% were found to have BMI values which were above the normal. Among the obese PCOS patients, 58% had BMI values of more than 30kg/ as compared to 19% of the patients who did not have AN. Type 2 DM was observed in 77% of the PCOS patients with AN, while none of the PCOS patients were found to be diabetic among those without AN. A family history of DM in the first degree relatives was present in all the patients with AN. The results were analyzed by the Mann Whitney U test for the continuous data and by the Chi square test for the categorical data. Conclusion: The PCOS patients who had a family history of diabetes and obesity with a body mass index of more than 30 kg/ and a waist circumference of ≥ 90 cm were more likely to develop AN, which is a marker of hyperinsulinaemia and insulin resistance. Identifying such PCOS patients will stimulate the discussions of the lifestyle modifications in the primary care setting.

Original languageEnglish
Pages (from-to)317-319
Number of pages3
JournalJournal of Clinical and Diagnostic Research
Volume7
Issue number2
DOIs
Publication statusPublished - 01-02-2013

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Polycystic Ovary Syndrome
Tertiary Healthcare
Medical problems
Acanthosis Nigricans
Tertiary Care Centers
Type 2 Diabetes Mellitus
India
Body Mass Index
Medicine
Insulin
Waist Circumference
Hyperinsulinism
Chi-Square Distribution
Nonparametric Statistics
Longitudinal Studies
Insulin Resistance
Life Style
Primary Health Care
Diabetes Mellitus

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Shivaprakash, G. ; Basu, A. ; Kamath, Ashwin ; Shivaprakash, Pallavi ; Adhikari, Prabha ; Rathnakar, U. P. ; Gopalakrishna, H. N. ; Padubidri, Jagadish Rao. / Acanthosis nigricansin PCOS patients and its relation with type 2 diabetes mellitus and body mass at a tertiary care hospital in Southern India. In: Journal of Clinical and Diagnostic Research. 2013 ; Vol. 7, No. 2. pp. 317-319.
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abstract = "Background: Acanthosis nigricansis was viewed recently as a possible marker of an increased risk for diabetes. Acanthosis Nigricans (AN) can help in identifying the patients with an increased risk for Type 2 Diabetes Mellitus (T2DM) among Polycystic Ovary Syndrome (PCOS) cases. Hence, this study was carried to know the prevalence of AN in PCOS and its correlation with diabetes mellitus and the body mass. Methods: A prospective, longitudinal study in the patients with PCOS, who attended the Department of Medicine, Kasturba Medical College [KMC] Hospital, Attavar, Mangalore, Karnatka, India between December 2008 to April 2010, was carried out. A total of 119 patients with PCOS were included in the study. A complete history, along with the demographic data of the patients who were aged between 15-35 years, were considered for the analysis. Results: AN was observed in 56{\%} of the PCOS patients. The Body Mass Index (BMI) and the waist circumference were significantly higher in the PCOS patients with AN, as compared to those without AN. Among the 119 PCOS patients, 77{\%} were found to have BMI values which were above the normal. Among the obese PCOS patients, 58{\%} had BMI values of more than 30kg/ as compared to 19{\%} of the patients who did not have AN. Type 2 DM was observed in 77{\%} of the PCOS patients with AN, while none of the PCOS patients were found to be diabetic among those without AN. A family history of DM in the first degree relatives was present in all the patients with AN. The results were analyzed by the Mann Whitney U test for the continuous data and by the Chi square test for the categorical data. Conclusion: The PCOS patients who had a family history of diabetes and obesity with a body mass index of more than 30 kg/ and a waist circumference of ≥ 90 cm were more likely to develop AN, which is a marker of hyperinsulinaemia and insulin resistance. Identifying such PCOS patients will stimulate the discussions of the lifestyle modifications in the primary care setting.",
author = "G. Shivaprakash and A. Basu and Ashwin Kamath and Pallavi Shivaprakash and Prabha Adhikari and Rathnakar, {U. P.} and Gopalakrishna, {H. N.} and Padubidri, {Jagadish Rao}",
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Acanthosis nigricansin PCOS patients and its relation with type 2 diabetes mellitus and body mass at a tertiary care hospital in Southern India. / Shivaprakash, G.; Basu, A.; Kamath, Ashwin; Shivaprakash, Pallavi; Adhikari, Prabha; Rathnakar, U. P.; Gopalakrishna, H. N.; Padubidri, Jagadish Rao.

In: Journal of Clinical and Diagnostic Research, Vol. 7, No. 2, 01.02.2013, p. 317-319.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acanthosis nigricansin PCOS patients and its relation with type 2 diabetes mellitus and body mass at a tertiary care hospital in Southern India

AU - Shivaprakash, G.

AU - Basu, A.

AU - Kamath, Ashwin

AU - Shivaprakash, Pallavi

AU - Adhikari, Prabha

AU - Rathnakar, U. P.

AU - Gopalakrishna, H. N.

AU - Padubidri, Jagadish Rao

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Background: Acanthosis nigricansis was viewed recently as a possible marker of an increased risk for diabetes. Acanthosis Nigricans (AN) can help in identifying the patients with an increased risk for Type 2 Diabetes Mellitus (T2DM) among Polycystic Ovary Syndrome (PCOS) cases. Hence, this study was carried to know the prevalence of AN in PCOS and its correlation with diabetes mellitus and the body mass. Methods: A prospective, longitudinal study in the patients with PCOS, who attended the Department of Medicine, Kasturba Medical College [KMC] Hospital, Attavar, Mangalore, Karnatka, India between December 2008 to April 2010, was carried out. A total of 119 patients with PCOS were included in the study. A complete history, along with the demographic data of the patients who were aged between 15-35 years, were considered for the analysis. Results: AN was observed in 56% of the PCOS patients. The Body Mass Index (BMI) and the waist circumference were significantly higher in the PCOS patients with AN, as compared to those without AN. Among the 119 PCOS patients, 77% were found to have BMI values which were above the normal. Among the obese PCOS patients, 58% had BMI values of more than 30kg/ as compared to 19% of the patients who did not have AN. Type 2 DM was observed in 77% of the PCOS patients with AN, while none of the PCOS patients were found to be diabetic among those without AN. A family history of DM in the first degree relatives was present in all the patients with AN. The results were analyzed by the Mann Whitney U test for the continuous data and by the Chi square test for the categorical data. Conclusion: The PCOS patients who had a family history of diabetes and obesity with a body mass index of more than 30 kg/ and a waist circumference of ≥ 90 cm were more likely to develop AN, which is a marker of hyperinsulinaemia and insulin resistance. Identifying such PCOS patients will stimulate the discussions of the lifestyle modifications in the primary care setting.

AB - Background: Acanthosis nigricansis was viewed recently as a possible marker of an increased risk for diabetes. Acanthosis Nigricans (AN) can help in identifying the patients with an increased risk for Type 2 Diabetes Mellitus (T2DM) among Polycystic Ovary Syndrome (PCOS) cases. Hence, this study was carried to know the prevalence of AN in PCOS and its correlation with diabetes mellitus and the body mass. Methods: A prospective, longitudinal study in the patients with PCOS, who attended the Department of Medicine, Kasturba Medical College [KMC] Hospital, Attavar, Mangalore, Karnatka, India between December 2008 to April 2010, was carried out. A total of 119 patients with PCOS were included in the study. A complete history, along with the demographic data of the patients who were aged between 15-35 years, were considered for the analysis. Results: AN was observed in 56% of the PCOS patients. The Body Mass Index (BMI) and the waist circumference were significantly higher in the PCOS patients with AN, as compared to those without AN. Among the 119 PCOS patients, 77% were found to have BMI values which were above the normal. Among the obese PCOS patients, 58% had BMI values of more than 30kg/ as compared to 19% of the patients who did not have AN. Type 2 DM was observed in 77% of the PCOS patients with AN, while none of the PCOS patients were found to be diabetic among those without AN. A family history of DM in the first degree relatives was present in all the patients with AN. The results were analyzed by the Mann Whitney U test for the continuous data and by the Chi square test for the categorical data. Conclusion: The PCOS patients who had a family history of diabetes and obesity with a body mass index of more than 30 kg/ and a waist circumference of ≥ 90 cm were more likely to develop AN, which is a marker of hyperinsulinaemia and insulin resistance. Identifying such PCOS patients will stimulate the discussions of the lifestyle modifications in the primary care setting.

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