Accuracy of self-reported adherence to tuberculosis therapy among DOTS patients in Mumbai

Nalini Sathiakumar, Suparna Bagchi, Deepinder Singh, Paul Kingsley Vijay, Guirish Ambe

Research output: Contribution to journalArticle

Abstract

Purpose: To compared self-reported adherence to DOTS therapy with urine rifampicin metabolite levels and medical records among patients in Mumbai, India. Methods: Study subjects (N=538) were randomly selected from the DOTS centers in Mumbai, India. Self-reported adherence was ascertained by interviews; unannounced home visits were conducted, and urine samples were collected for rifampicin metabolite testing using the n-butanol test. Information from medical records was abstracted for documented receipt of drugs from the DOTS centers. Results: Agreement between self-reported adherence and urine tests was very poor (kappa, 0.08); and between self-reports and medical records was moderate (kappa, 0.47). Receipt of drugs did not ensure adherence. Based on urine n-butanol test, 75% of patients were adherent. Physical appearance of urine for rifampicin excretion with the n-butanol extraction method indicated a high positive predictive value (95%). Conclusion: We recommend incorporating urine tests for various drug metabolites periodically in the DOTS program to ensure treatment adherence.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalInternational Journal of Health Research
Volume3
Issue number3
Publication statusPublished - 01-09-2010
Externally publishedYes

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Tuberculosis
Urine
1-Butanol
Rifampin
Medical Records
India
Therapeutics
Pharmaceutical Preparations
House Calls
Self Report
Interviews

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Sathiakumar, N., Bagchi, S., Singh, D., Vijay, P. K., & Ambe, G. (2010). Accuracy of self-reported adherence to tuberculosis therapy among DOTS patients in Mumbai. International Journal of Health Research, 3(3), 133-137.
Sathiakumar, Nalini ; Bagchi, Suparna ; Singh, Deepinder ; Vijay, Paul Kingsley ; Ambe, Guirish. / Accuracy of self-reported adherence to tuberculosis therapy among DOTS patients in Mumbai. In: International Journal of Health Research. 2010 ; Vol. 3, No. 3. pp. 133-137.
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Sathiakumar, N, Bagchi, S, Singh, D, Vijay, PK & Ambe, G 2010, 'Accuracy of self-reported adherence to tuberculosis therapy among DOTS patients in Mumbai', International Journal of Health Research, vol. 3, no. 3, pp. 133-137.

Accuracy of self-reported adherence to tuberculosis therapy among DOTS patients in Mumbai. / Sathiakumar, Nalini; Bagchi, Suparna; Singh, Deepinder; Vijay, Paul Kingsley; Ambe, Guirish.

In: International Journal of Health Research, Vol. 3, No. 3, 01.09.2010, p. 133-137.

Research output: Contribution to journalArticle

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