Aceclofenac ethosomes for enhanced transdermal delivery

2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009

S. Lewis, V. Dave, BioMed Central - The Open Access Publisher; simpleware

Research output: Contribution to conferencePaper

2 Citations (Scopus)

Abstract

The oral administration of aceclofenac has often resulted in side effects with chronic use. Using the transdermal route eliminates these side effects. Aceclofenac ethosomes were prepared and incorporated into a gel to enhance the skin permeability of aceclofenac. Ethosomal system comprised of phospholipids, ethanol, propylene glycol and lecithin. Different formulations were prepared with varying concentrations of lecithin and ethanol. The optical microscopy confirmed the formulation of multilamellar vesicles. The vesicle size of the ethosomes ranged between 0.696-1.140μm. Surface morphology was conducted by scanning electron microscopy. The entrapment efficiency was determined by centrifugation method. Effect of ethanol and lecithin concentration on entrapment of ethosomes was observed. Franz diffusion cell was used to evaluate the in vitro transdermal permeability of aceclofenac ethosomes. The studies were carried out using mouse skin as well as commercial sigma membrane. The in vitro drug permeation of the optimised formulation was compared with commercial conventional gel-Ziynac gel. The flux values of different ethosomal formulation were observed between 116.5μg/cm2/hr to 226.15μg/cm2 /hr. Formulation 5 showed maximum J value 226.1 as compared to marketed one 131.5μg/cm2 /hr. From the results of the present study it can be concluded that ethosomes improve the transdermal flux, prolong the release and represent an active carrier for sustained transdermal delivery. ©2009 IEEE.
Original languageEnglish
DOIs
Publication statusPublished - 2009

Fingerprint

Biomedical Engineering
Lecithins
Ethanol
Gels
Pharmaceutical Preparations
Permeability
Propylene Glycol
Skin
Centrifugation
Electron Scanning Microscopy
Oral Administration
Microscopy
Phospholipids
Membranes
aceclofenac
In Vitro Techniques

Cite this

@conference{4b3f6685f1d249109a1e8a333a23e25a,
title = "Aceclofenac ethosomes for enhanced transdermal delivery: 2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009",
abstract = "The oral administration of aceclofenac has often resulted in side effects with chronic use. Using the transdermal route eliminates these side effects. Aceclofenac ethosomes were prepared and incorporated into a gel to enhance the skin permeability of aceclofenac. Ethosomal system comprised of phospholipids, ethanol, propylene glycol and lecithin. Different formulations were prepared with varying concentrations of lecithin and ethanol. The optical microscopy confirmed the formulation of multilamellar vesicles. The vesicle size of the ethosomes ranged between 0.696-1.140μm. Surface morphology was conducted by scanning electron microscopy. The entrapment efficiency was determined by centrifugation method. Effect of ethanol and lecithin concentration on entrapment of ethosomes was observed. Franz diffusion cell was used to evaluate the in vitro transdermal permeability of aceclofenac ethosomes. The studies were carried out using mouse skin as well as commercial sigma membrane. The in vitro drug permeation of the optimised formulation was compared with commercial conventional gel-Ziynac gel. The flux values of different ethosomal formulation were observed between 116.5μg/cm2/hr to 226.15μg/cm2 /hr. Formulation 5 showed maximum J value 226.1 as compared to marketed one 131.5μg/cm2 /hr. From the results of the present study it can be concluded that ethosomes improve the transdermal flux, prolong the release and represent an active carrier for sustained transdermal delivery. {\circledC}2009 IEEE.",
author = "S. Lewis and V. Dave and simpleware, {BioMed Central - The Open Access Publisher;}",
note = "Conference code: 79720 Cited By :2 Export Date: 10 November 2017 Correspondence Address: Lewis, S.; Manipal College of Pharmaceutical Sciences, Manipal University, 576 104 Karnataka, India References: Yamazaki, R., Kawai, S., Mastsuzaki, T., Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors (1997) Eur. J.Pharmacol, 329, pp. 181-187; Touitou, E., Godin, B., Weiss, C., Enhanced delivery of drugs into and across the skin by ethosomal carriers (2000) Drug Dev Res, 50, pp. 406-415; Touitou, E., Dayan, N., Bergelson, L., Ethosomes-novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties (2000) J Control Release, 65, pp. 403-418; El Maghraby, G.M.M., Williams, A.C., Barry, B.W., Oestradiol skin delivery from ultradeformable liposo.mes: Refinement of surfactant concentration (2000) Int J Pharm., 196, pp. 63-74; Dayan, N., Touitou, E., Percutaneous Penetration Enhancers (2000) Biomaterials, 21, pp. 1879-1885; Fry, D.W., White, J.C., Goldman, I.D., Rapid secretion of low molecular weight solutes from liposomes without dilution (1978) Anal. Biochem., 90, pp. 809-815; Dubey, V., Jain, N.K., Dermal and transdermal delivery of an antipsoriatic agent via ethanolic liposome (2007) J.Contr. Release, 123, pp. 148-154; Lasic, D., Weiner, N., Riaz, M., Martin, F., Liposomes (1998) Pharmaceutical Dosage Forms: Disperse Systems, 3, pp. 43-86. , Lieberman A, Rieger M, Banker G, eds. New York, NY: Marcel Dekker; Jain, S., Umamaheshwari, R.B., Bhadra, D., Jain, N.K., Ethosomes: A novel vesicular carries for enhanced transdermal delivery of an anti HIV agent (2004) Ind J Pharm Sci., 66, pp. 72-81; Jain, S., Jain, N., Bhadra, D., Tiwary, A.K., Jain, N.K., Ethosomes: A Recent approach in Transdermal/Topical drug delivery (2005) Curr Drug Deliv., 2 (3), pp. 222-233; Jain, S., Tiwary, A.K., Jain, N.K., Sustained and targeted transdermal delivery of an anti-HIV agent using elastic liposomal formulation: Mechanism of action (2006) Curr Drug Deliv., 3 (2), pp. 157-164; Touitou, E., Godin, B., Weiss, C., Enhanced delivery of drugs into and across the skin by ethosomal carriers (2000) Drug Dev Res, 50, pp. 406-415; Touitou, E., Godin, B., Dayan, N., Weiss, C., Piliponsky, A., Levi-Schaffer, F., Intracellular delivery mediated by an ethosomal carrier (2001) Biomaterials, 22, pp. 3053-3059; Horwitz, E., Pisanty, S., Czerninski, R., Helser, M., Eliav, E., Touitou, E., A Clinical Evaluation of a Novel Liposomal Carrier for Aciclovir in the Topical Treatment of Recurrent Herpes Labialis (1999) Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 88, pp. 700-705",
year = "2009",
doi = "10.1109/ICBPE.2009.5384096",
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Aceclofenac ethosomes for enhanced transdermal delivery : 2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009. / Lewis, S.; Dave, V.; simpleware, BioMed Central - The Open Access Publisher;.

2009.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Aceclofenac ethosomes for enhanced transdermal delivery

T2 - 2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009

AU - Lewis, S.

AU - Dave, V.

AU - simpleware, BioMed Central - The Open Access Publisher;

N1 - Conference code: 79720 Cited By :2 Export Date: 10 November 2017 Correspondence Address: Lewis, S.; Manipal College of Pharmaceutical Sciences, Manipal University, 576 104 Karnataka, India References: Yamazaki, R., Kawai, S., Mastsuzaki, T., Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors (1997) Eur. J.Pharmacol, 329, pp. 181-187; Touitou, E., Godin, B., Weiss, C., Enhanced delivery of drugs into and across the skin by ethosomal carriers (2000) Drug Dev Res, 50, pp. 406-415; Touitou, E., Dayan, N., Bergelson, L., Ethosomes-novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties (2000) J Control Release, 65, pp. 403-418; El Maghraby, G.M.M., Williams, A.C., Barry, B.W., Oestradiol skin delivery from ultradeformable liposo.mes: Refinement of surfactant concentration (2000) Int J Pharm., 196, pp. 63-74; Dayan, N., Touitou, E., Percutaneous Penetration Enhancers (2000) Biomaterials, 21, pp. 1879-1885; Fry, D.W., White, J.C., Goldman, I.D., Rapid secretion of low molecular weight solutes from liposomes without dilution (1978) Anal. Biochem., 90, pp. 809-815; Dubey, V., Jain, N.K., Dermal and transdermal delivery of an antipsoriatic agent via ethanolic liposome (2007) J.Contr. Release, 123, pp. 148-154; Lasic, D., Weiner, N., Riaz, M., Martin, F., Liposomes (1998) Pharmaceutical Dosage Forms: Disperse Systems, 3, pp. 43-86. , Lieberman A, Rieger M, Banker G, eds. New York, NY: Marcel Dekker; Jain, S., Umamaheshwari, R.B., Bhadra, D., Jain, N.K., Ethosomes: A novel vesicular carries for enhanced transdermal delivery of an anti HIV agent (2004) Ind J Pharm Sci., 66, pp. 72-81; Jain, S., Jain, N., Bhadra, D., Tiwary, A.K., Jain, N.K., Ethosomes: A Recent approach in Transdermal/Topical drug delivery (2005) Curr Drug Deliv., 2 (3), pp. 222-233; Jain, S., Tiwary, A.K., Jain, N.K., Sustained and targeted transdermal delivery of an anti-HIV agent using elastic liposomal formulation: Mechanism of action (2006) Curr Drug Deliv., 3 (2), pp. 157-164; Touitou, E., Godin, B., Weiss, C., Enhanced delivery of drugs into and across the skin by ethosomal carriers (2000) Drug Dev Res, 50, pp. 406-415; Touitou, E., Godin, B., Dayan, N., Weiss, C., Piliponsky, A., Levi-Schaffer, F., Intracellular delivery mediated by an ethosomal carrier (2001) Biomaterials, 22, pp. 3053-3059; Horwitz, E., Pisanty, S., Czerninski, R., Helser, M., Eliav, E., Touitou, E., A Clinical Evaluation of a Novel Liposomal Carrier for Aciclovir in the Topical Treatment of Recurrent Herpes Labialis (1999) Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 88, pp. 700-705

PY - 2009

Y1 - 2009

N2 - The oral administration of aceclofenac has often resulted in side effects with chronic use. Using the transdermal route eliminates these side effects. Aceclofenac ethosomes were prepared and incorporated into a gel to enhance the skin permeability of aceclofenac. Ethosomal system comprised of phospholipids, ethanol, propylene glycol and lecithin. Different formulations were prepared with varying concentrations of lecithin and ethanol. The optical microscopy confirmed the formulation of multilamellar vesicles. The vesicle size of the ethosomes ranged between 0.696-1.140μm. Surface morphology was conducted by scanning electron microscopy. The entrapment efficiency was determined by centrifugation method. Effect of ethanol and lecithin concentration on entrapment of ethosomes was observed. Franz diffusion cell was used to evaluate the in vitro transdermal permeability of aceclofenac ethosomes. The studies were carried out using mouse skin as well as commercial sigma membrane. The in vitro drug permeation of the optimised formulation was compared with commercial conventional gel-Ziynac gel. The flux values of different ethosomal formulation were observed between 116.5μg/cm2/hr to 226.15μg/cm2 /hr. Formulation 5 showed maximum J value 226.1 as compared to marketed one 131.5μg/cm2 /hr. From the results of the present study it can be concluded that ethosomes improve the transdermal flux, prolong the release and represent an active carrier for sustained transdermal delivery. ©2009 IEEE.

AB - The oral administration of aceclofenac has often resulted in side effects with chronic use. Using the transdermal route eliminates these side effects. Aceclofenac ethosomes were prepared and incorporated into a gel to enhance the skin permeability of aceclofenac. Ethosomal system comprised of phospholipids, ethanol, propylene glycol and lecithin. Different formulations were prepared with varying concentrations of lecithin and ethanol. The optical microscopy confirmed the formulation of multilamellar vesicles. The vesicle size of the ethosomes ranged between 0.696-1.140μm. Surface morphology was conducted by scanning electron microscopy. The entrapment efficiency was determined by centrifugation method. Effect of ethanol and lecithin concentration on entrapment of ethosomes was observed. Franz diffusion cell was used to evaluate the in vitro transdermal permeability of aceclofenac ethosomes. The studies were carried out using mouse skin as well as commercial sigma membrane. The in vitro drug permeation of the optimised formulation was compared with commercial conventional gel-Ziynac gel. The flux values of different ethosomal formulation were observed between 116.5μg/cm2/hr to 226.15μg/cm2 /hr. Formulation 5 showed maximum J value 226.1 as compared to marketed one 131.5μg/cm2 /hr. From the results of the present study it can be concluded that ethosomes improve the transdermal flux, prolong the release and represent an active carrier for sustained transdermal delivery. ©2009 IEEE.

U2 - 10.1109/ICBPE.2009.5384096

DO - 10.1109/ICBPE.2009.5384096

M3 - Paper

ER -