Action of Hygrophila auriculata against streptozotocin-induced oxidative stress

M. Vijayakumar, R. Govindarajan, G.M.M. Rao, Ch.V. Rao, A. Shirwaikar, S. Mehrotra, P. Pushpangadan

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Hygrophila auriculata (K. Schum.) Heine (Family: Acanthaceae) is a wild herb widely used in 'Ayurveda' as 'Rasayana' drug for treatment of various disorders. Treatment of diabetic rats with aerial parts of Hygrophila auriculata extract (HAEt, 100 and 250 mg/kg body weight) for 3 weeks showed significant reduction in blood glucose, thiobarbituric acid reactive substances (TBARS) and hydroperoxide in both liver and kidney. The treatment with HAEt significantly increased the glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT) in the drug-treated group, which is comparable to the control group. HAEt and glibenclamide-treated rats also showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and catalase. The ability of HAEt on tissue lipid peroxidation and antioxidant status in diabetic animals has not been studied before. The result of this study thus shows that HAEt possesses significant antidiabetic activity along with potent antioxidant potential in diabetic conditions. © 2005 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)356-361
Number of pages6
JournalJournal of Ethnopharmacology
Volume104
Issue number3
DOIs
Publication statusPublished - 2006
Externally publishedYes

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Acanthaceae
Streptozocin
Oxidative Stress
Catalase
Lipid Peroxidation
Antioxidants
Thiobarbituric Acid Reactive Substances
Glyburide
Glutathione Peroxidase
Glutathione Transferase
Ireland
Hypoglycemic Agents
Pharmaceutical Preparations
Hydrogen Peroxide
Superoxide Dismutase
Glutathione
Blood Glucose
Body Weight
Kidney
Control Groups

Cite this

Vijayakumar, M., Govindarajan, R., Rao, G. M. M., Rao, C. V., Shirwaikar, A., Mehrotra, S., & Pushpangadan, P. (2006). Action of Hygrophila auriculata against streptozotocin-induced oxidative stress. Journal of Ethnopharmacology, 104(3), 356-361. https://doi.org/10.1016/j.jep.2005.09.030
Vijayakumar, M. ; Govindarajan, R. ; Rao, G.M.M. ; Rao, Ch.V. ; Shirwaikar, A. ; Mehrotra, S. ; Pushpangadan, P. / Action of Hygrophila auriculata against streptozotocin-induced oxidative stress. In: Journal of Ethnopharmacology. 2006 ; Vol. 104, No. 3. pp. 356-361.
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title = "Action of Hygrophila auriculata against streptozotocin-induced oxidative stress",
abstract = "Hygrophila auriculata (K. Schum.) Heine (Family: Acanthaceae) is a wild herb widely used in 'Ayurveda' as 'Rasayana' drug for treatment of various disorders. Treatment of diabetic rats with aerial parts of Hygrophila auriculata extract (HAEt, 100 and 250 mg/kg body weight) for 3 weeks showed significant reduction in blood glucose, thiobarbituric acid reactive substances (TBARS) and hydroperoxide in both liver and kidney. The treatment with HAEt significantly increased the glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT) in the drug-treated group, which is comparable to the control group. HAEt and glibenclamide-treated rats also showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and catalase. The ability of HAEt on tissue lipid peroxidation and antioxidant status in diabetic animals has not been studied before. The result of this study thus shows that HAEt possesses significant antidiabetic activity along with potent antioxidant potential in diabetic conditions. {\circledC} 2005 Elsevier Ireland Ltd. All rights reserved.",
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note = "Cited By :65 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Pushpangadan, P.; Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226 001, Uttar Pradesh, India; email: pushpangadan@satyam.net.in Chemicals/CAS: catalase, 9001-05-2; glibenclamide, 10238-21-8; glucose, 50-99-7, 84778-64-3; glutathione peroxidase, 9013-66-5; glutathione transferase, 50812-37-8; glutathione, 70-18-8; streptozocin, 18883-66-4; Antioxidants; Blood Glucose; Catalase, EC 1.11.1.6; Glutathione Peroxidase, EC 1.11.1.9; Glutathione Transferase, EC 2.5.1.18; Glutathione, 70-18-8; Glyburide, 10238-21-8; Plant Extracts; Superoxide Dismutase, EC 1.15.1.1; Thiobarbituric Acid Reactive Substances Manufacturers: Sigma, United States References: Aebi, H., Catalase (1974) Methods in Enzymatic Analysis, 3, pp. 276-286. , H.U. Bergmeyer Academic Press New York; Ahmed, S., Rahman, A., Mathur, M., Athar, M., Sultana, S., Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats (2001) Food and Chemical Technology, 39, pp. 19-28; Baynes, J.W., Perspectives in diabetes, role of oxidative stress on development of complications in diabetes (1991) Diabetes, 40, pp. 405-412; Cao, G., Sotic, E., Prior, R., Antioxidant and prooxidant behaviour of flavanoids: Structure-activity relationships (1997) Free Radicals in Biology and Medicine, 22, pp. 749-760; Elman, G.L., Tissue sulphydryl groups (1959) Archives in Biochemistry and Biophysics, 82, pp. 70-77; Feillet, C.C., Rock, E., Coudray, C., Grzelkowska, K., Azais, B.V., Dardevet, D., Lipid peroxidation and antioxidant status in experimental diabetes (1999) Clinica Chimica Acta, 284, pp. 31-43; Fernando, M.R., Wickramasinghe, S.M.D.N., Thabrew, M.I., Karunanayaka, E.H., A preliminary investigation of the possible hypoglycemic activity of Asteracanthus longifolia (1989) Journal of Ethnopharmacology, 27, pp. 7-14; Frei, B., Molecular and biological mechanism of antioxidant action (1999) The FASEB Journal, 13, pp. 963-964; Furusho, T., Kataoka, E., Yasuhara, T., Wada, M., Innami, S., Administration of β-carotene suppresses lipid peroxidation in tissues and improves the glucose tolerance ability of streptozotocin induced diabetic rats (2002) International Journal of Vitamins and Nutrition Research, 72, pp. 71-76; Govindarajan, R., Rastogi, S., Vijayakumar, M., Rawat, A.K.S., Shirwaikar, A., Mehrotra, S., Pushpangadan, P., Studies on the antioxidant activities of Desmodium gangeticum (2003) Biological and Pharmaceutical Bulletin, 26, pp. 1424-1427; Grankvist, K., Marklund, S., Taljedal, I.B., Superoxide dismutase is prophylactic against alloxan diabetes (1981) Nature, 294, pp. 158-161; Habig, W.H., Pabst, M.S., Jekpoly, W.B., Glutathione transferase: A first enzymatic step in mercapturic acid formation (1974) Journal of Biological Chemistry, 249, pp. 7130-7139; Heikkila, R.G., Winston, B., Cohen, G., Barden, H., Alloxan induced diabetes: Evidence of hydroxyl radical as a cytotoxic intermediate (1976) Biochemical Pharmacology, 25, pp. 1085-1092; Henry, J.B., (1984) Clinical Diagnosis and Management by Laboratory Methods, , 17th ed. Saunders Philadelphia, USA; Hunt, J.V., Smith, C.C.T., Wolff, S.P., Auto-oxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose (1990) Diabetes, 39, pp. 1420-1424; Illing, E.K.B., Gray, C.H., Lawrence, R.D., Blood glutathione and non glucose reducing substances in diabetes (1991) Biochemical Journal, 48, p. 637; Jain, S.K., (1991) Dictionary of Indian Folk Medicine and Ethnobotany, , Deep Publications New Delhi, India; Jayatilak, P.G., Pardanani, D.S., Murty, B.D., Seth, A.R., Effect of an indigenous drug (speman) on accessory reproductive fucntions of mice (1976) Indian Journal of Experimental Biology, 14, pp. 170-173; Jiang, Z.Y., Hunt, J.V., Wolff, S.D., Ferrous ion oxidation in the presence of Xylenol Orange for detection of lipid hydroperoxide in low density lipoprotein (1992) Analytical Biochemistry, 202, pp. 384-389; Loven, D., Schedl, H., Wilson, H., Daabees, T.T., Stegink, L.D., Diekus, M., Effect of insulin and oral glutathione on glutathione levels and superoxide dismutase activities in organs of rats with streptozotocin induced (1986) Diabetes, 35, pp. 503-507; Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.I., Protein determination using Folin-Ciocalteau reagent (1951) Journal of Biological Chemistry, 193, pp. 438-448; Mazmudar, U.K., Gupta, M., Maiti, S., Mukherji, B., Antitumor activity of Hygrophila spinosa on Ehrlich ascites carcinoma and sarcoma 180 induced in mice (1997) Indian Journal of Experimental Biology, 35, pp. 473-477; Mertz, S.A., Oxygenation products of arachidonic acid: Third messengers for insulin release (1984) Prostaglandins, 27, pp. 147-1451; Mukherjee, B., Mukherjee, J.H., Chatterjee, M., Lipid peroxidation, glutathione levels and change in glutathione-related enzymes activities in streptozotocin-induced diabetic rats (1994) Immunology and Cell Biology, 72, pp. 109-111; Nakakimura, H., Mizuno, K., Studies on lipid peroxidation in biological system II. Hyperlipoperoxidemia in mice induced by alloxan (1980) Chemical and Pharmaceutical Bulletin, 28, pp. 2207-2211; Oberly, L.W., Free radicals and diabetes (1988) Free Radical in Biology and Medicine, 5, pp. 113-116; Okhawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction (1979) Analytical Biochemistry, 95, pp. 351-358; Popov, G., Lewin, B., Photoluminescent detection of antiradical activity. I: Assay of superoxide dismutase (1987) Biomedica Biochimica Acta, 11, pp. 775-779; Quasim, C., Dutta, N.L., Chemical investigation of Asteracantha longifolia Nees. (1967) Journal of Indian of Chemical Society, 44, pp. 82-83; Rotruck, J.T., Pope, A.L., Ganther, H.E., Swanson, A.B., Selenium: Biochemical roles as a component of glutathione peroxidase (1973) Science, 179, pp. 588-590; Santhakumari, P., Prakasam, A., Pugalendi, K.V., Modulation of oxidative stress parmeters by treatment with Piper betel leaf in streptozotocin induced diabetic rats (2003) Indian Journal of Pharmacology, 35, pp. 373-378; Sasaki, T., Matzy, S., Sonal, A., Effect of acetic acid concentration on the colour reaction in the O-toluidine boric acid method for blood glucose estimation (1972) Rinsho Kagaku, 1, pp. 346-353; Sato, Y., Hotto, N., Sakamoto, N., Matsuoka, S., Ohishi, N., Yafi, K., Lipid peroxide level in plasma of diabetic patients (1979) Biochemical Medicine, 2, pp. 104-107; Shailajan, S., Chandra, N., Sane, R.T., Menon, S., Effect of Asteracantha longifolia Nees. against CCl4 induced liver dysfunction in rat (2005) Indian Journal of Experimental Biology, 43, pp. 68-75; Siddique, O., Sun, Y., Lin, J.C., Chien, Y.W., Facilitated transdermal transport of insulin (1989) Journal of Pharmaceutical Sciences, 76, pp. 341-345; Singh, A., Handa, S.S., Hepatoprotective activity of graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats (1999) Journal of Ethnopharmacology, 49, pp. 119-126; Vaya, J., Belinky, P., Aviram, M., Anti oxidant constituents from licorice roots: Isolation structure elucidation and antioxidative capacity toward LDC oxidation (1997) Free Radicals in Biology and Medicine, 23, pp. 302-313; Venkateswaran, S., Pari, L., Effect of Coccinia indica leaves on antioxidant status in streptozotocin induced diabetic rats (2003) Journal of Ethnopharmacology, 84, pp. 163-168; WHO Expert Committee on Diabetes mellitus, 1980. Technical Report Series 646, Second Report. World Health Organization, GenevaUR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644830095&doi=10.1016{\%}2fj.jep.2005.09.030&partnerID=40&md5=07a6c51d5be759b13e3c2b2283d93d2d",
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Vijayakumar, M, Govindarajan, R, Rao, GMM, Rao, CV, Shirwaikar, A, Mehrotra, S & Pushpangadan, P 2006, 'Action of Hygrophila auriculata against streptozotocin-induced oxidative stress', Journal of Ethnopharmacology, vol. 104, no. 3, pp. 356-361. https://doi.org/10.1016/j.jep.2005.09.030

Action of Hygrophila auriculata against streptozotocin-induced oxidative stress. / Vijayakumar, M.; Govindarajan, R.; Rao, G.M.M.; Rao, Ch.V.; Shirwaikar, A.; Mehrotra, S.; Pushpangadan, P.

In: Journal of Ethnopharmacology, Vol. 104, No. 3, 2006, p. 356-361.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Action of Hygrophila auriculata against streptozotocin-induced oxidative stress

AU - Vijayakumar, M.

AU - Govindarajan, R.

AU - Rao, G.M.M.

AU - Rao, Ch.V.

AU - Shirwaikar, A.

AU - Mehrotra, S.

AU - Pushpangadan, P.

N1 - Cited By :65 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Pushpangadan, P.; Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226 001, Uttar Pradesh, India; email: pushpangadan@satyam.net.in Chemicals/CAS: catalase, 9001-05-2; glibenclamide, 10238-21-8; glucose, 50-99-7, 84778-64-3; glutathione peroxidase, 9013-66-5; glutathione transferase, 50812-37-8; glutathione, 70-18-8; streptozocin, 18883-66-4; Antioxidants; Blood Glucose; Catalase, EC 1.11.1.6; Glutathione Peroxidase, EC 1.11.1.9; Glutathione Transferase, EC 2.5.1.18; Glutathione, 70-18-8; Glyburide, 10238-21-8; Plant Extracts; Superoxide Dismutase, EC 1.15.1.1; Thiobarbituric Acid Reactive Substances Manufacturers: Sigma, United States References: Aebi, H., Catalase (1974) Methods in Enzymatic Analysis, 3, pp. 276-286. , H.U. Bergmeyer Academic Press New York; Ahmed, S., Rahman, A., Mathur, M., Athar, M., Sultana, S., Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats (2001) Food and Chemical Technology, 39, pp. 19-28; Baynes, J.W., Perspectives in diabetes, role of oxidative stress on development of complications in diabetes (1991) Diabetes, 40, pp. 405-412; Cao, G., Sotic, E., Prior, R., Antioxidant and prooxidant behaviour of flavanoids: Structure-activity relationships (1997) Free Radicals in Biology and Medicine, 22, pp. 749-760; Elman, G.L., Tissue sulphydryl groups (1959) Archives in Biochemistry and Biophysics, 82, pp. 70-77; Feillet, C.C., Rock, E., Coudray, C., Grzelkowska, K., Azais, B.V., Dardevet, D., Lipid peroxidation and antioxidant status in experimental diabetes (1999) Clinica Chimica Acta, 284, pp. 31-43; Fernando, M.R., Wickramasinghe, S.M.D.N., Thabrew, M.I., Karunanayaka, E.H., A preliminary investigation of the possible hypoglycemic activity of Asteracanthus longifolia (1989) Journal of Ethnopharmacology, 27, pp. 7-14; Frei, B., Molecular and biological mechanism of antioxidant action (1999) The FASEB Journal, 13, pp. 963-964; Furusho, T., Kataoka, E., Yasuhara, T., Wada, M., Innami, S., Administration of β-carotene suppresses lipid peroxidation in tissues and improves the glucose tolerance ability of streptozotocin induced diabetic rats (2002) International Journal of Vitamins and Nutrition Research, 72, pp. 71-76; Govindarajan, R., Rastogi, S., Vijayakumar, M., Rawat, A.K.S., Shirwaikar, A., Mehrotra, S., Pushpangadan, P., Studies on the antioxidant activities of Desmodium gangeticum (2003) Biological and Pharmaceutical Bulletin, 26, pp. 1424-1427; Grankvist, K., Marklund, S., Taljedal, I.B., Superoxide dismutase is prophylactic against alloxan diabetes (1981) Nature, 294, pp. 158-161; Habig, W.H., Pabst, M.S., Jekpoly, W.B., Glutathione transferase: A first enzymatic step in mercapturic acid formation (1974) Journal of Biological Chemistry, 249, pp. 7130-7139; Heikkila, R.G., Winston, B., Cohen, G., Barden, H., Alloxan induced diabetes: Evidence of hydroxyl radical as a cytotoxic intermediate (1976) Biochemical Pharmacology, 25, pp. 1085-1092; Henry, J.B., (1984) Clinical Diagnosis and Management by Laboratory Methods, , 17th ed. Saunders Philadelphia, USA; Hunt, J.V., Smith, C.C.T., Wolff, S.P., Auto-oxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose (1990) Diabetes, 39, pp. 1420-1424; Illing, E.K.B., Gray, C.H., Lawrence, R.D., Blood glutathione and non glucose reducing substances in diabetes (1991) Biochemical Journal, 48, p. 637; Jain, S.K., (1991) Dictionary of Indian Folk Medicine and Ethnobotany, , Deep Publications New Delhi, India; Jayatilak, P.G., Pardanani, D.S., Murty, B.D., Seth, A.R., Effect of an indigenous drug (speman) on accessory reproductive fucntions of mice (1976) Indian Journal of Experimental Biology, 14, pp. 170-173; Jiang, Z.Y., Hunt, J.V., Wolff, S.D., Ferrous ion oxidation in the presence of Xylenol Orange for detection of lipid hydroperoxide in low density lipoprotein (1992) Analytical Biochemistry, 202, pp. 384-389; Loven, D., Schedl, H., Wilson, H., Daabees, T.T., Stegink, L.D., Diekus, M., Effect of insulin and oral glutathione on glutathione levels and superoxide dismutase activities in organs of rats with streptozotocin induced (1986) Diabetes, 35, pp. 503-507; Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.I., Protein determination using Folin-Ciocalteau reagent (1951) Journal of Biological Chemistry, 193, pp. 438-448; Mazmudar, U.K., Gupta, M., Maiti, S., Mukherji, B., Antitumor activity of Hygrophila spinosa on Ehrlich ascites carcinoma and sarcoma 180 induced in mice (1997) Indian Journal of Experimental Biology, 35, pp. 473-477; Mertz, S.A., Oxygenation products of arachidonic acid: Third messengers for insulin release (1984) Prostaglandins, 27, pp. 147-1451; Mukherjee, B., Mukherjee, J.H., Chatterjee, M., Lipid peroxidation, glutathione levels and change in glutathione-related enzymes activities in streptozotocin-induced diabetic rats (1994) Immunology and Cell Biology, 72, pp. 109-111; Nakakimura, H., Mizuno, K., Studies on lipid peroxidation in biological system II. Hyperlipoperoxidemia in mice induced by alloxan (1980) Chemical and Pharmaceutical Bulletin, 28, pp. 2207-2211; Oberly, L.W., Free radicals and diabetes (1988) Free Radical in Biology and Medicine, 5, pp. 113-116; Okhawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction (1979) Analytical Biochemistry, 95, pp. 351-358; Popov, G., Lewin, B., Photoluminescent detection of antiradical activity. I: Assay of superoxide dismutase (1987) Biomedica Biochimica Acta, 11, pp. 775-779; Quasim, C., Dutta, N.L., Chemical investigation of Asteracantha longifolia Nees. (1967) Journal of Indian of Chemical Society, 44, pp. 82-83; Rotruck, J.T., Pope, A.L., Ganther, H.E., Swanson, A.B., Selenium: Biochemical roles as a component of glutathione peroxidase (1973) Science, 179, pp. 588-590; Santhakumari, P., Prakasam, A., Pugalendi, K.V., Modulation of oxidative stress parmeters by treatment with Piper betel leaf in streptozotocin induced diabetic rats (2003) Indian Journal of Pharmacology, 35, pp. 373-378; Sasaki, T., Matzy, S., Sonal, A., Effect of acetic acid concentration on the colour reaction in the O-toluidine boric acid method for blood glucose estimation (1972) Rinsho Kagaku, 1, pp. 346-353; Sato, Y., Hotto, N., Sakamoto, N., Matsuoka, S., Ohishi, N., Yafi, K., Lipid peroxide level in plasma of diabetic patients (1979) Biochemical Medicine, 2, pp. 104-107; Shailajan, S., Chandra, N., Sane, R.T., Menon, S., Effect of Asteracantha longifolia Nees. against CCl4 induced liver dysfunction in rat (2005) Indian Journal of Experimental Biology, 43, pp. 68-75; Siddique, O., Sun, Y., Lin, J.C., Chien, Y.W., Facilitated transdermal transport of insulin (1989) Journal of Pharmaceutical Sciences, 76, pp. 341-345; Singh, A., Handa, S.S., Hepatoprotective activity of graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats (1999) Journal of Ethnopharmacology, 49, pp. 119-126; Vaya, J., Belinky, P., Aviram, M., Anti oxidant constituents from licorice roots: Isolation structure elucidation and antioxidative capacity toward LDC oxidation (1997) Free Radicals in Biology and Medicine, 23, pp. 302-313; Venkateswaran, S., Pari, L., Effect of Coccinia indica leaves on antioxidant status in streptozotocin induced diabetic rats (2003) Journal of Ethnopharmacology, 84, pp. 163-168; WHO Expert Committee on Diabetes mellitus, 1980. Technical Report Series 646, Second Report. World Health Organization, GenevaUR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644830095&doi=10.1016%2fj.jep.2005.09.030&partnerID=40&md5=07a6c51d5be759b13e3c2b2283d93d2d

PY - 2006

Y1 - 2006

N2 - Hygrophila auriculata (K. Schum.) Heine (Family: Acanthaceae) is a wild herb widely used in 'Ayurveda' as 'Rasayana' drug for treatment of various disorders. Treatment of diabetic rats with aerial parts of Hygrophila auriculata extract (HAEt, 100 and 250 mg/kg body weight) for 3 weeks showed significant reduction in blood glucose, thiobarbituric acid reactive substances (TBARS) and hydroperoxide in both liver and kidney. The treatment with HAEt significantly increased the glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT) in the drug-treated group, which is comparable to the control group. HAEt and glibenclamide-treated rats also showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and catalase. The ability of HAEt on tissue lipid peroxidation and antioxidant status in diabetic animals has not been studied before. The result of this study thus shows that HAEt possesses significant antidiabetic activity along with potent antioxidant potential in diabetic conditions. © 2005 Elsevier Ireland Ltd. All rights reserved.

AB - Hygrophila auriculata (K. Schum.) Heine (Family: Acanthaceae) is a wild herb widely used in 'Ayurveda' as 'Rasayana' drug for treatment of various disorders. Treatment of diabetic rats with aerial parts of Hygrophila auriculata extract (HAEt, 100 and 250 mg/kg body weight) for 3 weeks showed significant reduction in blood glucose, thiobarbituric acid reactive substances (TBARS) and hydroperoxide in both liver and kidney. The treatment with HAEt significantly increased the glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT) in the drug-treated group, which is comparable to the control group. HAEt and glibenclamide-treated rats also showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and catalase. The ability of HAEt on tissue lipid peroxidation and antioxidant status in diabetic animals has not been studied before. The result of this study thus shows that HAEt possesses significant antidiabetic activity along with potent antioxidant potential in diabetic conditions. © 2005 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.jep.2005.09.030

DO - 10.1016/j.jep.2005.09.030

M3 - Article

VL - 104

SP - 356

EP - 361

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 3

ER -

Vijayakumar M, Govindarajan R, Rao GMM, Rao CV, Shirwaikar A, Mehrotra S et al. Action of Hygrophila auriculata against streptozotocin-induced oxidative stress. Journal of Ethnopharmacology. 2006;104(3):356-361. https://doi.org/10.1016/j.jep.2005.09.030