In the recent years, Human Immunodeficiency Virus (HIV) has infected millions of people around the globe, making it an important public health concern of the future. Candida species found as a commensal is the most common etiology of oropharyngeal candidiasis, an opportunistic fungal infection seen in HIV patients. The objective of the present study was to determine the anti-candidal activity of Solanum lycopersicum (tomato) extract on oral Candida species isolated from HIV positive patients. 30 oral rinse samples were collected from retro-positive patients attending the anti-retroviral therapy center. Standard culture techniques were followed for the identification of yeast. Of the total 30 samples, 13 samples grew Candida species belonging to Candida albicans (77%), Candida guilliermondii (15%) and Candida lusitaniae (8%). The mean CD4 count was 386. About 61% (n=8/13) of Candida species were susceptible to Fluconazole (MIC >0.50 µg/mL) and 39% (n=5/13) were resistant (MIC <0.50 µg/mL). Ethanolic extract of Solanum lycopersicum showed anti-candidal activity at MIC and MFC 6.25mg/mL for the drug-resistant Candida species. Further exploring the phytochemical components present in Solanum lycopersicum could help be an alternative treatment modality to fight the increase in drug resistance seen in Candida species.
|Number of pages||4|
|Journal||Journal of Pharmaceutical Sciences and Research|
|Publication status||Published - 01-07-2017|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science