Abstract

Xanthium strumarium Linn. is used in Indian and Chinese complementary medicines for its various therapeutic properties. There are reports stating that the plant is toxic and lethal to cattle and swine. We have studied the oral toxicity of chloroform and hexane soluble fractions of root extract of X. strumarium in Wistar rats. The toxicity determination was done according to the Organization for Economic Cooperation and Development guidelines. In the acute study with a single oral dose of extracts at 5 g/kg body weight, there was no mortality or signs of toxicity. In the subacute study, none of the blood elements were significantly affected in male and female rats after 28 days. Acute and subacute administration of chloroform and hexane soluble fractions of root did not produce any adverse reactions or any significant changes in organ weight, mortality, and the body weights as compared to untreated controls. Administration of these extracts did not alter the hepatic and renal function, and did not produce any change in the hematological parameters. The study indicates that acute and subacute administration of X. strumarium did not produce any toxicity to rats as evident from weight change, mortality, and limited biochemical and histopathological analysis. Hence, the extracts are considered as unclassified and are found to be safe.

Original languageEnglish
Pages (from-to)1223-1230
Number of pages8
JournalComparative Clinical Pathology
Volume21
Issue number6
DOIs
Publication statusPublished - 12-2012

Fingerprint

Xanthium
Chloroform
Hexanes
Mortality
Body Weight
Toxic Plants
Organ Size
Complementary Therapies
Wistar Rats
Swine
Guidelines
Kidney
Weights and Measures
Liver
Therapeutics

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

@article{53750d8ad2ed41c980d6368e358f0f92,
title = "Acute and subacute toxicity of chloroform and hexaneextracts of root of Xanthium strumarium",
abstract = "Xanthium strumarium Linn. is used in Indian and Chinese complementary medicines for its various therapeutic properties. There are reports stating that the plant is toxic and lethal to cattle and swine. We have studied the oral toxicity of chloroform and hexane soluble fractions of root extract of X. strumarium in Wistar rats. The toxicity determination was done according to the Organization for Economic Cooperation and Development guidelines. In the acute study with a single oral dose of extracts at 5 g/kg body weight, there was no mortality or signs of toxicity. In the subacute study, none of the blood elements were significantly affected in male and female rats after 28 days. Acute and subacute administration of chloroform and hexane soluble fractions of root did not produce any adverse reactions or any significant changes in organ weight, mortality, and the body weights as compared to untreated controls. Administration of these extracts did not alter the hepatic and renal function, and did not produce any change in the hematological parameters. The study indicates that acute and subacute administration of X. strumarium did not produce any toxicity to rats as evident from weight change, mortality, and limited biochemical and histopathological analysis. Hence, the extracts are considered as unclassified and are found to be safe.",
author = "Aranjani, {Jesil Mathew} and Rao, {Chamallamudi Mallikarjuna} and Atulya Manuel and Rao, {Josyula Venkata} and Nayanabhirama Udupa and Karteek Hebbar",
year = "2012",
month = "12",
doi = "10.1007/s00580-011-1269-5",
language = "English",
volume = "21",
pages = "1223--1230",
journal = "Comparative Clinical Pathology",
issn = "1618-5641",
publisher = "Springer London",
number = "6",

}

Acute and subacute toxicity of chloroform and hexaneextracts of root of Xanthium strumarium. / Aranjani, Jesil Mathew; Rao, Chamallamudi Mallikarjuna; Manuel, Atulya; Rao, Josyula Venkata; Udupa, Nayanabhirama; Hebbar, Karteek.

In: Comparative Clinical Pathology, Vol. 21, No. 6, 12.2012, p. 1223-1230.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acute and subacute toxicity of chloroform and hexaneextracts of root of Xanthium strumarium

AU - Aranjani, Jesil Mathew

AU - Rao, Chamallamudi Mallikarjuna

AU - Manuel, Atulya

AU - Rao, Josyula Venkata

AU - Udupa, Nayanabhirama

AU - Hebbar, Karteek

PY - 2012/12

Y1 - 2012/12

N2 - Xanthium strumarium Linn. is used in Indian and Chinese complementary medicines for its various therapeutic properties. There are reports stating that the plant is toxic and lethal to cattle and swine. We have studied the oral toxicity of chloroform and hexane soluble fractions of root extract of X. strumarium in Wistar rats. The toxicity determination was done according to the Organization for Economic Cooperation and Development guidelines. In the acute study with a single oral dose of extracts at 5 g/kg body weight, there was no mortality or signs of toxicity. In the subacute study, none of the blood elements were significantly affected in male and female rats after 28 days. Acute and subacute administration of chloroform and hexane soluble fractions of root did not produce any adverse reactions or any significant changes in organ weight, mortality, and the body weights as compared to untreated controls. Administration of these extracts did not alter the hepatic and renal function, and did not produce any change in the hematological parameters. The study indicates that acute and subacute administration of X. strumarium did not produce any toxicity to rats as evident from weight change, mortality, and limited biochemical and histopathological analysis. Hence, the extracts are considered as unclassified and are found to be safe.

AB - Xanthium strumarium Linn. is used in Indian and Chinese complementary medicines for its various therapeutic properties. There are reports stating that the plant is toxic and lethal to cattle and swine. We have studied the oral toxicity of chloroform and hexane soluble fractions of root extract of X. strumarium in Wistar rats. The toxicity determination was done according to the Organization for Economic Cooperation and Development guidelines. In the acute study with a single oral dose of extracts at 5 g/kg body weight, there was no mortality or signs of toxicity. In the subacute study, none of the blood elements were significantly affected in male and female rats after 28 days. Acute and subacute administration of chloroform and hexane soluble fractions of root did not produce any adverse reactions or any significant changes in organ weight, mortality, and the body weights as compared to untreated controls. Administration of these extracts did not alter the hepatic and renal function, and did not produce any change in the hematological parameters. The study indicates that acute and subacute administration of X. strumarium did not produce any toxicity to rats as evident from weight change, mortality, and limited biochemical and histopathological analysis. Hence, the extracts are considered as unclassified and are found to be safe.

UR - http://www.scopus.com/inward/record.url?scp=84870623249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870623249&partnerID=8YFLogxK

U2 - 10.1007/s00580-011-1269-5

DO - 10.1007/s00580-011-1269-5

M3 - Article

VL - 21

SP - 1223

EP - 1230

JO - Comparative Clinical Pathology

JF - Comparative Clinical Pathology

SN - 1618-5641

IS - 6

ER -