Acute flaccid paralysis due to West nile virus infection in adults

A paradigm shift entity

Boby Varkey Maramattom, Geetha Philips, Nittur Sudheesh, Govindakarnavar Arunkumar

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Three cases of acute flaccid paralysis (AFP) with preceding fever are described. One patient had a quadriparesis with a florid meningoencephalitic picture and the other two had asymmetric flaccid paralysis with fasciculations at the onset of illness. Magnetic resonance imaging in two cases showed prominent hyperintensitities in the spinal cord and brainstem with prominent involvement of the grey horn (polio-myelitis). Cerebrospinal fluid (CSF) polymerase chain reaction was positive for West Nile virus (WNV) in the index patient. All three cases had a positive WNV immunoglobulin M antibody in serum/CSF and significantly high titer of WNV neutralizing antibody in serum, clearly distinguishing the infection from other Flaviviridae such as Japanese encephalitis. WNV has been recognized in India for many decades; however, AFP has not been adequately described. WNV is a flavivirus that is spread by Culex mosquitoes while they take blood meals from humans and lineage 1 is capable of causing a devastating neuro-invasive disease with fatal consequences or severe morbidity. We describe the first three laboratory confirmed cases of WNV induced AFP from Kerala and briefly enumerate the salient features of this emerging threat.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalAnnals of Indian Academy of Neurology
Volume17
Issue number1
DOIs
Publication statusPublished - 2014

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West Nile virus
Virus Diseases
Paralysis
Flaviviridae Infections
Cerebrospinal Fluid
Japanese Encephalitis
Myelitis
Fasciculation
Flavivirus
Culex
Quadriplegia
Poliomyelitis
Horns
Neutralizing Antibodies
Culicidae
Serum
Brain Stem
Immunoglobulin M
Meals
India

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

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abstract = "Three cases of acute flaccid paralysis (AFP) with preceding fever are described. One patient had a quadriparesis with a florid meningoencephalitic picture and the other two had asymmetric flaccid paralysis with fasciculations at the onset of illness. Magnetic resonance imaging in two cases showed prominent hyperintensitities in the spinal cord and brainstem with prominent involvement of the grey horn (polio-myelitis). Cerebrospinal fluid (CSF) polymerase chain reaction was positive for West Nile virus (WNV) in the index patient. All three cases had a positive WNV immunoglobulin M antibody in serum/CSF and significantly high titer of WNV neutralizing antibody in serum, clearly distinguishing the infection from other Flaviviridae such as Japanese encephalitis. WNV has been recognized in India for many decades; however, AFP has not been adequately described. WNV is a flavivirus that is spread by Culex mosquitoes while they take blood meals from humans and lineage 1 is capable of causing a devastating neuro-invasive disease with fatal consequences or severe morbidity. We describe the first three laboratory confirmed cases of WNV induced AFP from Kerala and briefly enumerate the salient features of this emerging threat.",
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Acute flaccid paralysis due to West nile virus infection in adults : A paradigm shift entity. / Maramattom, Boby Varkey; Philips, Geetha; Sudheesh, Nittur; Arunkumar, Govindakarnavar.

In: Annals of Indian Academy of Neurology, Vol. 17, No. 1, 2014, p. 85-88.

Research output: Contribution to journalArticle

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