Acute oral toxicity of VTH pills in wistar rats

Seema Rai, Yogesh Belagali, D. Ullal Sheetal, H. N. Gopalakrishna, Sahana D. Acharya, Akash, B. S. Nishchal, K. Ashok Shenoy

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Abstract

Objectives: To evaluate the acute oral toxicity of VTH pills in wistar rats Methods: The study was conducted in two phases: initial and continuation phase. In the initial phase there were two groups: control and test, with ten rats (5 male and 5 female) in each group. The control group received 2% gum acacia (vehicle) 10mg/kg; the test group received 5000mg/kg of VTH pillssuspended in 2% gum acacia,orally as a single dose on day 1. All the animals were observed for clinical signs of toxicity and/or death at 1hour (±10min), 2hours (±10min), 4hours (±10min) and 6hours (±10min) on day 1 and thereafter once daily for 14 days. On day 15, the animals were subjected to necropsy. In the continuation study, 30 rats were divided into three groups receiving 2000, 1000 and 500mg/kg VTH pills respectively. Behavioural toxicity analysis was done at the end of the continuation study. Results:There was no mortality andthere wasalso no biochemical, hematological or histopathological changes at any of the doses. However, VTH pills showed significant behavioral toxicity at 5000mg/kg which was reduced at 2000mg/kg. No behavioral toxicity was noted at 500 or 1000mg/kg body weight. Conclusion: The test item, VTH pill is non-toxic upto and at 1000 mg/kg when administered by oral gavage in a single dose to wistar rats.

Original languageEnglish
Pages (from-to)321-323
Number of pages3
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume5
Issue numberSUPPL.1
Publication statusPublished - 02-04-2013

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Gum Arabic
Wistar Rats
Control Groups
Body Weight
Mortality

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Rai, S., Belagali, Y., Ullal Sheetal, D., Gopalakrishna, H. N., Acharya, S. D., Akash, ... Ashok Shenoy, K. (2013). Acute oral toxicity of VTH pills in wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences, 5(SUPPL.1), 321-323.
Rai, Seema ; Belagali, Yogesh ; Ullal Sheetal, D. ; Gopalakrishna, H. N. ; Acharya, Sahana D. ; Akash ; Nishchal, B. S. ; Ashok Shenoy, K. / Acute oral toxicity of VTH pills in wistar rats. In: International Journal of Pharmacy and Pharmaceutical Sciences. 2013 ; Vol. 5, No. SUPPL.1. pp. 321-323.
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Rai, S, Belagali, Y, Ullal Sheetal, D, Gopalakrishna, HN, Acharya, SD, Akash, Nishchal, BS & Ashok Shenoy, K 2013, 'Acute oral toxicity of VTH pills in wistar rats', International Journal of Pharmacy and Pharmaceutical Sciences, vol. 5, no. SUPPL.1, pp. 321-323.

Acute oral toxicity of VTH pills in wistar rats. / Rai, Seema; Belagali, Yogesh; Ullal Sheetal, D.; Gopalakrishna, H. N.; Acharya, Sahana D.; Akash; Nishchal, B. S.; Ashok Shenoy, K.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 5, No. SUPPL.1, 02.04.2013, p. 321-323.

Research output: Contribution to journalArticle

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AU - Akash,

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Rai S, Belagali Y, Ullal Sheetal D, Gopalakrishna HN, Acharya SD, Akash et al. Acute oral toxicity of VTH pills in wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2013 Apr 2;5(SUPPL.1):321-323.