Acute thyrotoxic neuropathy - Basedow's paraplegia revisited

Lekha Pandit, S. K. Shankar, N. Gayathri, Ashok Pandit

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A forty seven year old woman with previously undetected goitre, developed thyroid storm in the immediate postoperative period. Forty eight hours after undergoing nephrolithotomy for renal calculus, she was noted to have flaccid areflexic quadriparesis, most marked in the lower limbs. Electrophysiologic studies revealed evidence of an asymmetric, mixed axonal and demyelinating, motor-sensory peripheral neuropathy. Ultrastructure of the sural nerve showed predominant abnormalities in the mitochondria and cytoskeletal elements compatible with thyrotoxicosis. Treatment of thyrotoxicosis coincided with recovery of symptoms. We believe that thyrotoxicosis precipitated an acute polyneuropathy the ultrastructure of which is being described for the first time.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalJournal of the Neurological Sciences
Volume155
Issue number2
DOIs
Publication statusPublished - 05-03-1998
Externally publishedYes

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Thyrotoxicosis
Paraplegia
Thyroid Crisis
Sural Nerve
Quadriplegia
Kidney Calculi
Polyneuropathies
Goiter
Peripheral Nervous System Diseases
Postoperative Period
Lower Extremity
Mitochondria
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Pandit, Lekha ; Shankar, S. K. ; Gayathri, N. ; Pandit, Ashok. / Acute thyrotoxic neuropathy - Basedow's paraplegia revisited. In: Journal of the Neurological Sciences. 1998 ; Vol. 155, No. 2. pp. 211-214.
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Acute thyrotoxic neuropathy - Basedow's paraplegia revisited. / Pandit, Lekha; Shankar, S. K.; Gayathri, N.; Pandit, Ashok.

In: Journal of the Neurological Sciences, Vol. 155, No. 2, 05.03.1998, p. 211-214.

Research output: Contribution to journalArticle

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