Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats.

M. C.Satish Kumar; A. L. Udupa; K. Sammodavardhana; U. P. Rathnakar; Udapa Shvetha; G. P. Kodancha

Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats.

M. C.Satish Kumar, A. L. Udupa, K. Sammodavardhana, U. P. Rathnakar, Udapa Shvetha, G. P. Kodancha

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Asparagus racemosus Willd has been used as diuretic in Ayurveda but has not been validated by a suitable experimental model. Hence the present study was undertaken. MATERIALS AND METHODS: The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study. RESULTS: Acute toxicity study showed no fatality even with the highest dose and the diuretic study revealed significant diuretic activity (p < 0.05) in the dose of 3200 mg/kg. CONCLUSION: Asparagus racemosus showed diuretic activity at a 3200 mg/kg dose without acute toxicity.

Original language	English
Pages (from-to)	3-6
Number of pages	4
Journal	The West Indian medical journal
Volume	59
Issue number	1
Publication status	Published - 01-01-2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

Cite this

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title = "Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats.",

abstract = "OBJECTIVE: Asparagus racemosus Willd has been used as diuretic in Ayurveda but has not been validated by a suitable experimental model. Hence the present study was undertaken. MATERIALS AND METHODS: The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study. RESULTS: Acute toxicity study showed no fatality even with the highest dose and the diuretic study revealed significant diuretic activity (p < 0.05) in the dose of 3200 mg/kg. CONCLUSION: Asparagus racemosus showed diuretic activity at a 3200 mg/kg dose without acute toxicity.",

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T1 - Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats.

AU - Kumar, M. C.Satish

AU - Udupa, A. L.

AU - Sammodavardhana, K.

AU - Rathnakar, U. P.

AU - Shvetha, Udapa

AU - Kodancha, G. P.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - OBJECTIVE: Asparagus racemosus Willd has been used as diuretic in Ayurveda but has not been validated by a suitable experimental model. Hence the present study was undertaken. MATERIALS AND METHODS: The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study. RESULTS: Acute toxicity study showed no fatality even with the highest dose and the diuretic study revealed significant diuretic activity (p < 0.05) in the dose of 3200 mg/kg. CONCLUSION: Asparagus racemosus showed diuretic activity at a 3200 mg/kg dose without acute toxicity.

AB - OBJECTIVE: Asparagus racemosus Willd has been used as diuretic in Ayurveda but has not been validated by a suitable experimental model. Hence the present study was undertaken. MATERIALS AND METHODS: The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study. RESULTS: Acute toxicity study showed no fatality even with the highest dose and the diuretic study revealed significant diuretic activity (p < 0.05) in the dose of 3200 mg/kg. CONCLUSION: Asparagus racemosus showed diuretic activity at a 3200 mg/kg dose without acute toxicity.

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Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats.

Abstract

All Science Journal Classification (ASJC) codes

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