Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats.

M. C.Satish Kumar, A. L. Udupa, K. Sammodavardhana, U. P. Rathnakar, Udapa Shvetha, G. P. Kodancha

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVE: Asparagus racemosus Willd has been used as diuretic in Ayurveda but has not been validated by a suitable experimental model. Hence the present study was undertaken. MATERIALS AND METHODS: The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study. RESULTS: Acute toxicity study showed no fatality even with the highest dose and the diuretic study revealed significant diuretic activity (p < 0.05) in the dose of 3200 mg/kg. CONCLUSION: Asparagus racemosus showed diuretic activity at a 3200 mg/kg dose without acute toxicity.

Original languageEnglish
Pages (from-to)3-6
Number of pages4
JournalThe West Indian medical journal
Volume59
Issue number1
Publication statusPublished - 01-01-2010
Externally publishedYes

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Diuretics
Drug and Narcotic Control
Furosemide
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kumar, M. C. S., Udupa, A. L., Sammodavardhana, K., Rathnakar, U. P., Shvetha, U., & Kodancha, G. P. (2010). Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats. The West Indian medical journal, 59(1), 3-6.
Kumar, M. C.Satish ; Udupa, A. L. ; Sammodavardhana, K. ; Rathnakar, U. P. ; Shvetha, Udapa ; Kodancha, G. P. / Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats. In: The West Indian medical journal. 2010 ; Vol. 59, No. 1. pp. 3-6.
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Kumar, MCS, Udupa, AL, Sammodavardhana, K, Rathnakar, UP, Shvetha, U & Kodancha, GP 2010, 'Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats.', The West Indian medical journal, vol. 59, no. 1, pp. 3-6.

Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats. / Kumar, M. C.Satish; Udupa, A. L.; Sammodavardhana, K.; Rathnakar, U. P.; Shvetha, Udapa; Kodancha, G. P.

In: The West Indian medical journal, Vol. 59, No. 1, 01.01.2010, p. 3-6.

Research output: Contribution to journalArticle

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AU - Shvetha, Udapa

AU - Kodancha, G. P.

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Kumar MCS, Udupa AL, Sammodavardhana K, Rathnakar UP, Shvetha U, Kodancha GP. Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats. The West Indian medical journal. 2010 Jan 1;59(1):3-6.