Acyclovir entrapped N-trimethyl chitosan nanoparticles for oral bioavailability enhancement

Ushasree Medikonduri, Zenab Attari, Krishnamurthy Bhat, Shaila Lewis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The aim of the study was to evaluate a nanoparticulate system composed of Ntrimethyl chitosan (TMC) for improving the oral bioavailability of Acyclovir (ACV). Methods: TMC was prepared by methylation of chitosan and characterized by H-NMR spectroscopy. The ionic gelation method was used to prepare ACV loaded TMC nanoparticles. Non-everted sac technique was used to assess ex vivo permeation in rats. A pharmacokinetic study of the optimized formulation was carried out in male Wistar rats in comparison with ACV alone. Results: Ex vivo studies exhibited a significant rise in the permeation of ACV from the rat intestinal membrane when formulated as nanoparticles. The results showed an increase in plasma concentration of ACV from the nanoformulation and significant difference (p < 0.05) in pharmacokinetic parameters as compared to pure drug, ACV. Conclusion: The results suggest that higher oral delivery of ACV can be achieved by combining the benefits of both TMC and nanoparticles.

Original languageEnglish
Pages (from-to)378-385
Number of pages8
JournalCurrent Nanoscience
Volume12
Issue number3
Publication statusPublished - 01-06-2016

Fingerprint

Acyclovir
Chitosan
Nanoparticles
Biological Availability
Rats
Pharmacokinetics
Permeation
Methylation
Gelation
Nuclear magnetic resonance spectroscopy
Membranes
Plasmas
N-trimethyl chitosan chloride
Wistar Rats
Magnetic Resonance Spectroscopy
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine (miscellaneous)
  • Bioengineering
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

@article{915d2687c3554277a740d0d945972db1,
title = "Acyclovir entrapped N-trimethyl chitosan nanoparticles for oral bioavailability enhancement",
abstract = "Objective: The aim of the study was to evaluate a nanoparticulate system composed of Ntrimethyl chitosan (TMC) for improving the oral bioavailability of Acyclovir (ACV). Methods: TMC was prepared by methylation of chitosan and characterized by H-NMR spectroscopy. The ionic gelation method was used to prepare ACV loaded TMC nanoparticles. Non-everted sac technique was used to assess ex vivo permeation in rats. A pharmacokinetic study of the optimized formulation was carried out in male Wistar rats in comparison with ACV alone. Results: Ex vivo studies exhibited a significant rise in the permeation of ACV from the rat intestinal membrane when formulated as nanoparticles. The results showed an increase in plasma concentration of ACV from the nanoformulation and significant difference (p < 0.05) in pharmacokinetic parameters as compared to pure drug, ACV. Conclusion: The results suggest that higher oral delivery of ACV can be achieved by combining the benefits of both TMC and nanoparticles.",
author = "Ushasree Medikonduri and Zenab Attari and Krishnamurthy Bhat and Shaila Lewis",
note = "cited By 0",
year = "2016",
month = "6",
day = "1",
language = "English",
volume = "12",
pages = "378--385",
journal = "Current Nanoscience",
issn = "1573-4137",
publisher = "Bentham Science Publishers B.V.",
number = "3",

}

Acyclovir entrapped N-trimethyl chitosan nanoparticles for oral bioavailability enhancement. / Medikonduri, Ushasree; Attari, Zenab; Bhat, Krishnamurthy; Lewis, Shaila.

In: Current Nanoscience, Vol. 12, No. 3, 01.06.2016, p. 378-385.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acyclovir entrapped N-trimethyl chitosan nanoparticles for oral bioavailability enhancement

AU - Medikonduri, Ushasree

AU - Attari, Zenab

AU - Bhat, Krishnamurthy

AU - Lewis, Shaila

N1 - cited By 0

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Objective: The aim of the study was to evaluate a nanoparticulate system composed of Ntrimethyl chitosan (TMC) for improving the oral bioavailability of Acyclovir (ACV). Methods: TMC was prepared by methylation of chitosan and characterized by H-NMR spectroscopy. The ionic gelation method was used to prepare ACV loaded TMC nanoparticles. Non-everted sac technique was used to assess ex vivo permeation in rats. A pharmacokinetic study of the optimized formulation was carried out in male Wistar rats in comparison with ACV alone. Results: Ex vivo studies exhibited a significant rise in the permeation of ACV from the rat intestinal membrane when formulated as nanoparticles. The results showed an increase in plasma concentration of ACV from the nanoformulation and significant difference (p < 0.05) in pharmacokinetic parameters as compared to pure drug, ACV. Conclusion: The results suggest that higher oral delivery of ACV can be achieved by combining the benefits of both TMC and nanoparticles.

AB - Objective: The aim of the study was to evaluate a nanoparticulate system composed of Ntrimethyl chitosan (TMC) for improving the oral bioavailability of Acyclovir (ACV). Methods: TMC was prepared by methylation of chitosan and characterized by H-NMR spectroscopy. The ionic gelation method was used to prepare ACV loaded TMC nanoparticles. Non-everted sac technique was used to assess ex vivo permeation in rats. A pharmacokinetic study of the optimized formulation was carried out in male Wistar rats in comparison with ACV alone. Results: Ex vivo studies exhibited a significant rise in the permeation of ACV from the rat intestinal membrane when formulated as nanoparticles. The results showed an increase in plasma concentration of ACV from the nanoformulation and significant difference (p < 0.05) in pharmacokinetic parameters as compared to pure drug, ACV. Conclusion: The results suggest that higher oral delivery of ACV can be achieved by combining the benefits of both TMC and nanoparticles.

UR - http://www.scopus.com/inward/record.url?scp=84964301732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964301732&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 378

EP - 385

JO - Current Nanoscience

JF - Current Nanoscience

SN - 1573-4137

IS - 3

ER -