Adenovirus infection enhances killing of melanoma cells by a mitotoxin

Kapaettu Satyamoorthy, Peter W. Soballe, Francis Soans, Meenhard Herlyn

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    9 Citations (Scopus)

    Abstract

    Toxins are effective in cell killing if internalized efficiently. Conjugation of the plant toxin saporin with basic fibroblast growth factor has increased tumor killing due to better internalization, but toxin uptake by cells has remained relatively inefficient. We show here that infection of melanoma cells with a replication-defective adenovirus enhances cell killing by the mitotoxin basic fibroblast growth factor-saporin more than 10-fold, thus allowing tumor cell killing in vivo at nontoxic concentrations. Adenovirus infection leads to increased apoptosis by the mitotoxin due to enhanced internalization of the ligand-receptor complex and release of the active toxin from the endosomes.

    Original languageEnglish
    Pages (from-to)1873-1876
    Number of pages4
    JournalCancer Research
    Volume57
    Issue number10
    Publication statusPublished - 15-05-1997

    All Science Journal Classification (ASJC) codes

    • Cancer Research
    • Oncology

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  • Cite this

    Satyamoorthy, K., Soballe, P. W., Soans, F., & Herlyn, M. (1997). Adenovirus infection enhances killing of melanoma cells by a mitotoxin. Cancer Research, 57(10), 1873-1876.