Alleviating effect of gallic acid on dexamethasone induced insulin resistance in albino mice

S. B. Alvi, B. Mamatha, B. Veeresh

Research output: Contribution to journalArticle

Abstract

Gallic acid is a naturally occurring phenolic compound and is well known for its prominent antioxidant potential. This study aims to evaluate the protective effect of gallic acid on dexamethasone-induced insulin resistance. Dexamethasone is a steroid, clinically used to treat numerous inflammatory conditions. Acute exposure to this drug is known to produce insulin resistance inducing prediabetic condition and hyperglycemia. In the current study, 30 albino mice were divided into 5 groups containing equal number of animals; one of the group was administered with dexamethasone 1 mg/kg i.p. for 28 days to induce insulin resistance where as dexamethasone and gallic acid of 50 mg/kg p.o. and 100 mg/kg p.o. respectively were administered to two groups. Saline and pioglitazone was given to normal and standard control groups respectively. On 29th day, the serum samples and excised pancreatic tissues were collected for biochemical estimations. The serum analysis revealed that treatment with gallic acid effectively reduced elevated glucose, LDL, VLDL and increased HDL levels in a dose dependent manner. Additionally, it was found to decrease the MDA levels and elevate the GSH levels in pancreas. In conclusion, gallic acid treatment in dexamethasone-induced insulin resistant mice exhibited a protective effect.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalInternational Journal of Toxicological and Pharmacological Research
Volume8
Issue number1
Publication statusPublished - 01-02-2016

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Gallic Acid
Dexamethasone
Insulin Resistance
pioglitazone
Serum
Hyperglycemia
Pancreas
Antioxidants
Steroids
Insulin
Glucose
Control Groups
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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Alleviating effect of gallic acid on dexamethasone induced insulin resistance in albino mice. / Alvi, S. B.; Mamatha, B.; Veeresh, B.

In: International Journal of Toxicological and Pharmacological Research, Vol. 8, No. 1, 01.02.2016, p. 35-39.

Research output: Contribution to journalArticle

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