Alpha-amylase activity of tannin isolated from Terminalia chebula

Sutapa Mukherjee, Analava Mitra, Satyahari Dey, Goutam Thakur

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting certain carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the inhibitory effect of tannins isolated from the alcoholic extract of fruits of Terminalia chebula was evaluated for the first time with porcine pancreatic amylase and potato starch as substrate. The result indicated that highest inhibition (52%) was obtained at the concentration of 100g/ml of tannins extracted from the fruits. The result was comparable to that of Acarbose which is a very effective antidiabetic agent.

Original languageEnglish
Title of host publicationInternational Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings
Pages443-445
Number of pages3
DOIs
Publication statusPublished - 01-12-2010
EventInternational Conference on Systems in Medicine and Biology, ICSMB 2010 - Kharagpur, India
Duration: 16-12-201018-12-2010

Conference

ConferenceInternational Conference on Systems in Medicine and Biology, ICSMB 2010
CountryIndia
CityKharagpur
Period16-12-1018-12-10

Fingerprint

Terminalia
alpha-Amylases
Tannins
Fruit
Acarbose
Amylases
Solanum tuberosum
Hypoglycemic Agents
Starch
Type 2 Diabetes Mellitus
Swine
Carbohydrates
Glucose
Enzymes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Mukherjee, S., Mitra, A., Dey, S., & Thakur, G. (2010). Alpha-amylase activity of tannin isolated from Terminalia chebula. In International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings (pp. 443-445). [5735421] https://doi.org/10.1109/ICSMB.2010.5735421
Mukherjee, Sutapa ; Mitra, Analava ; Dey, Satyahari ; Thakur, Goutam. / Alpha-amylase activity of tannin isolated from Terminalia chebula. International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings. 2010. pp. 443-445
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Mukherjee, S, Mitra, A, Dey, S & Thakur, G 2010, Alpha-amylase activity of tannin isolated from Terminalia chebula. in International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings., 5735421, pp. 443-445, International Conference on Systems in Medicine and Biology, ICSMB 2010, Kharagpur, India, 16-12-10. https://doi.org/10.1109/ICSMB.2010.5735421

Alpha-amylase activity of tannin isolated from Terminalia chebula. / Mukherjee, Sutapa; Mitra, Analava; Dey, Satyahari; Thakur, Goutam.

International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings. 2010. p. 443-445 5735421.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting certain carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the inhibitory effect of tannins isolated from the alcoholic extract of fruits of Terminalia chebula was evaluated for the first time with porcine pancreatic amylase and potato starch as substrate. The result indicated that highest inhibition (52%) was obtained at the concentration of 100g/ml of tannins extracted from the fruits. The result was comparable to that of Acarbose which is a very effective antidiabetic agent.

AB - One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting certain carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the inhibitory effect of tannins isolated from the alcoholic extract of fruits of Terminalia chebula was evaluated for the first time with porcine pancreatic amylase and potato starch as substrate. The result indicated that highest inhibition (52%) was obtained at the concentration of 100g/ml of tannins extracted from the fruits. The result was comparable to that of Acarbose which is a very effective antidiabetic agent.

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Mukherjee S, Mitra A, Dey S, Thakur G. Alpha-amylase activity of tannin isolated from Terminalia chebula. In International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings. 2010. p. 443-445. 5735421 https://doi.org/10.1109/ICSMB.2010.5735421