Altered biochemical parameters in saliva of pediatric attention deficit hyperactivity disorder

E. Archana, Priya Pai, Bhavya K. Prabhu, Revathi P. Shenoy, Krishnananda Prabhu, Anjali Rao

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Oxidative stress is one of the common causes in etiopathogenesis of attention deficit hyperactivity disorder (ADHD). Hence, the salivary levels of protein thiols, ceruloplasmin, magnesium and pseudocholinesterase were estimated in children with ADHD. The symptoms of ADHD were identified using Conner's rating and DSM IV criteria. Saliva was collected and assessed for the levels of protein thiols, ceruloplasmin, magnesium and pseudocholinesterase, spectrophotometrically. It was also checked for pH and the flow rate was noted down. There was a significant increase (P < 0.001) in the salivary protein thiols and pseudocholinesterase levels in ADHD children when compared to controls. Ceruloplasmin levels did not show any significant change. Magnesium levels were significantly decreased (P < 0.001) in cases when compared to controls. Further, a receiver operating characteristic curve for validity of the biochemical parameters in saliva of ADHD children indicated a sensitivity and specificity above 90% for protein thiols and magnesium values. Our study shows that protein thiols, magnesium, and pseudocholinesterase might have a role in the pathogenesis of ADHD and saliva can be effectively used as a non-invasive tool for evaluation of such children.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalNeurochemical Research
Volume37
Issue number2
DOIs
Publication statusPublished - 01-02-2012

Fingerprint

Pediatrics
Pseudocholinesterase
Attention Deficit Disorder with Hyperactivity
Saliva
Sulfhydryl Compounds
Magnesium
Ceruloplasmin
Salivary Proteins and Peptides
Proteins
Oxidative stress
ROC Curve
Diagnostic and Statistical Manual of Mental Disorders
Flow rate
Oxidative Stress
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

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abstract = "Oxidative stress is one of the common causes in etiopathogenesis of attention deficit hyperactivity disorder (ADHD). Hence, the salivary levels of protein thiols, ceruloplasmin, magnesium and pseudocholinesterase were estimated in children with ADHD. The symptoms of ADHD were identified using Conner's rating and DSM IV criteria. Saliva was collected and assessed for the levels of protein thiols, ceruloplasmin, magnesium and pseudocholinesterase, spectrophotometrically. It was also checked for pH and the flow rate was noted down. There was a significant increase (P < 0.001) in the salivary protein thiols and pseudocholinesterase levels in ADHD children when compared to controls. Ceruloplasmin levels did not show any significant change. Magnesium levels were significantly decreased (P < 0.001) in cases when compared to controls. Further, a receiver operating characteristic curve for validity of the biochemical parameters in saliva of ADHD children indicated a sensitivity and specificity above 90{\%} for protein thiols and magnesium values. Our study shows that protein thiols, magnesium, and pseudocholinesterase might have a role in the pathogenesis of ADHD and saliva can be effectively used as a non-invasive tool for evaluation of such children.",
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Altered biochemical parameters in saliva of pediatric attention deficit hyperactivity disorder. / Archana, E.; Pai, Priya; Prabhu, Bhavya K.; Shenoy, Revathi P.; Prabhu, Krishnananda; Rao, Anjali.

In: Neurochemical Research, Vol. 37, No. 2, 01.02.2012, p. 330-334.

Research output: Contribution to journalArticle

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