13 Citations (Scopus)

Abstract

Monitoring people with diabetes by repeatedly estimating blood glucose and glycosylated hemoglobin levels is invasive which becomes appalling and expensive over time. Potential of saliva as a diagnostic tool could be exploited in this regard. 26 diabetes patients were com-pared with 21 age matched non-diabetic healthy controls for Fasting plasma glucose (FPG), salivary glucose (SG), salivary pH (SpH), Oral health status and markers of oxidative stress in saliva namely Thiobarbituric Acid Reactive substance (TBARS) or Malondialdehyde (MDA) and Total antioxidant activity (AOA). Significantly high FPG (p=0.005) along with high salivary AOA (p < 0.0001) levels, markedly lesser SpH and MDA were found in the di-abetic group. Changes in SG levels between the groups were of no consequence. FPG showed positive correlation to SG (r = 0.410) and even better correlation with salivary MDA (r = 0.562) only in diabetes. Since SG levels did not differ between the two groups, the study concludes that conventional marker like FPG is a better indicator of glycemic status. Lower MDA seen in saliva of diabetic group may be probably due to the exceptionally high AOA activity seen in these people.

Original languageEnglish
Pages (from-to)252-256
Number of pages5
JournalBiomedical Research
Volume21
Issue number3
Publication statusPublished - 2010

Fingerprint

Medical problems
Diabetes Mellitus
Glucose
Malondialdehyde
Fasting
Saliva
Plasmas
Antioxidants
Oxidative stress
Thiobarbituric Acid Reactive Substances
Oral Health
Glycosylated Hemoglobin A
Health Status
Blood Glucose
Oxidative Stress
Health
Monitoring

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hegde, Anupama ; Shenoy, Ramya ; D'Mello, Prajwal ; Smitha, A. ; Tintu, A. ; Manjrekar, Poornima. / Alternative markers of glycemic status in diabetes mellitus. In: Biomedical Research. 2010 ; Vol. 21, No. 3. pp. 252-256.
@article{c5722880a369449b8de72abce44777b7,
title = "Alternative markers of glycemic status in diabetes mellitus",
abstract = "Monitoring people with diabetes by repeatedly estimating blood glucose and glycosylated hemoglobin levels is invasive which becomes appalling and expensive over time. Potential of saliva as a diagnostic tool could be exploited in this regard. 26 diabetes patients were com-pared with 21 age matched non-diabetic healthy controls for Fasting plasma glucose (FPG), salivary glucose (SG), salivary pH (SpH), Oral health status and markers of oxidative stress in saliva namely Thiobarbituric Acid Reactive substance (TBARS) or Malondialdehyde (MDA) and Total antioxidant activity (AOA). Significantly high FPG (p=0.005) along with high salivary AOA (p < 0.0001) levels, markedly lesser SpH and MDA were found in the di-abetic group. Changes in SG levels between the groups were of no consequence. FPG showed positive correlation to SG (r = 0.410) and even better correlation with salivary MDA (r = 0.562) only in diabetes. Since SG levels did not differ between the two groups, the study concludes that conventional marker like FPG is a better indicator of glycemic status. Lower MDA seen in saliva of diabetic group may be probably due to the exceptionally high AOA activity seen in these people.",
author = "Anupama Hegde and Ramya Shenoy and Prajwal D'Mello and A. Smitha and A. Tintu and Poornima Manjrekar",
year = "2010",
language = "English",
volume = "21",
pages = "252--256",
journal = "Biomedical Research",
issn = "0970-938X",
publisher = "Scientific Publishers of India",
number = "3",

}

Alternative markers of glycemic status in diabetes mellitus. / Hegde, Anupama; Shenoy, Ramya; D'Mello, Prajwal; Smitha, A.; Tintu, A.; Manjrekar, Poornima.

In: Biomedical Research, Vol. 21, No. 3, 2010, p. 252-256.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alternative markers of glycemic status in diabetes mellitus

AU - Hegde, Anupama

AU - Shenoy, Ramya

AU - D'Mello, Prajwal

AU - Smitha, A.

AU - Tintu, A.

AU - Manjrekar, Poornima

PY - 2010

Y1 - 2010

N2 - Monitoring people with diabetes by repeatedly estimating blood glucose and glycosylated hemoglobin levels is invasive which becomes appalling and expensive over time. Potential of saliva as a diagnostic tool could be exploited in this regard. 26 diabetes patients were com-pared with 21 age matched non-diabetic healthy controls for Fasting plasma glucose (FPG), salivary glucose (SG), salivary pH (SpH), Oral health status and markers of oxidative stress in saliva namely Thiobarbituric Acid Reactive substance (TBARS) or Malondialdehyde (MDA) and Total antioxidant activity (AOA). Significantly high FPG (p=0.005) along with high salivary AOA (p < 0.0001) levels, markedly lesser SpH and MDA were found in the di-abetic group. Changes in SG levels between the groups were of no consequence. FPG showed positive correlation to SG (r = 0.410) and even better correlation with salivary MDA (r = 0.562) only in diabetes. Since SG levels did not differ between the two groups, the study concludes that conventional marker like FPG is a better indicator of glycemic status. Lower MDA seen in saliva of diabetic group may be probably due to the exceptionally high AOA activity seen in these people.

AB - Monitoring people with diabetes by repeatedly estimating blood glucose and glycosylated hemoglobin levels is invasive which becomes appalling and expensive over time. Potential of saliva as a diagnostic tool could be exploited in this regard. 26 diabetes patients were com-pared with 21 age matched non-diabetic healthy controls for Fasting plasma glucose (FPG), salivary glucose (SG), salivary pH (SpH), Oral health status and markers of oxidative stress in saliva namely Thiobarbituric Acid Reactive substance (TBARS) or Malondialdehyde (MDA) and Total antioxidant activity (AOA). Significantly high FPG (p=0.005) along with high salivary AOA (p < 0.0001) levels, markedly lesser SpH and MDA were found in the di-abetic group. Changes in SG levels between the groups were of no consequence. FPG showed positive correlation to SG (r = 0.410) and even better correlation with salivary MDA (r = 0.562) only in diabetes. Since SG levels did not differ between the two groups, the study concludes that conventional marker like FPG is a better indicator of glycemic status. Lower MDA seen in saliva of diabetic group may be probably due to the exceptionally high AOA activity seen in these people.

UR - http://www.scopus.com/inward/record.url?scp=78650070606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650070606&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 252

EP - 256

JO - Biomedical Research

JF - Biomedical Research

SN - 0970-938X

IS - 3

ER -