Methotrexate (MTX) is used as an anticancer drug in many types of cancer associated with organ toxicities. It generates free radicals responsible for tissue damage in organs like testis. Coconut water, a natural drink known for its nutritive values also possess components, which are rich in antioxidants. The present study was a novel study to evaluate the benefits of yellow and green varieties of coconut water in testicular damage caused by methotrexate in experimental animals. The study proved that, both the varieties of coconut water restored testicular structure and functions by recovering sperm function, testicular enzymes, antioxidant enzymes and improvement in tissue microscopy. We conclude that both green and yellow coconut water are beneficial and can be used as a natural remedy for methotrexate induced testicular toxicity.
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