Amyloidogenic pattern prediction of HIV-1 proteins

Patil Sneha, Balaji Seetharaman, Andrew J. Levine

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter reviews the roles of HIV-1 proteins in the neuropathogenesis and cognitive decline that occur in HIV-1-infected individuals. HIV-1 protein hydrophobic patterns and propensity to form secondary structures are addressed in conjunction with predicted amyloidogenic determinants for HIV-1 brain isolates. Their corresponding β-strand intermolecular pairing is also addressed. A comparative analysis with reference sequences is done to identify and confirm analogous properties and intrinsic factors. The predicted patterns and their sequence variation may serve to identify common features shared by amyloid fibrils that facilitate and enhance viral infectivity and an association with tissue damage.

Original languageEnglish
Title of host publicationGlobal Virology II - HIV and NeuroAIDS
PublisherSpringer New York
Pages823-895
Number of pages73
ISBN (Electronic)9781493972906
ISBN (Print)9781493972883
DOIs
Publication statusPublished - 01-01-2017

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

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