Amyloidogenic pattern prediction of HIV-1 proteins

Patil Sneha; Balaji Seetharaman; Andrew J. Levine

doi:10.1007/978-1-4939-7290-6_33

Amyloidogenic pattern prediction of HIV-1 proteins

Patil Sneha, Balaji Seetharaman, Andrew J. Levine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

This chapter reviews the roles of HIV-1 proteins in the neuropathogenesis and cognitive decline that occur in HIV-1-infected individuals. HIV-1 protein hydrophobic patterns and propensity to form secondary structures are addressed in conjunction with predicted amyloidogenic determinants for HIV-1 brain isolates. Their corresponding β-strand intermolecular pairing is also addressed. A comparative analysis with reference sequences is done to identify and confirm analogous properties and intrinsic factors. The predicted patterns and their sequence variation may serve to identify common features shared by amyloid fibrils that facilitate and enhance viral infectivity and an association with tissue damage.

Original language	English
Title of host publication	Global Virology II - HIV and NeuroAIDS
Publisher	Springer New York
Pages	823-895
Number of pages	73
ISBN (Electronic)	9781493972906
ISBN (Print)	9781493972883
DOIs	https://doi.org/10.1007/978-1-4939-7290-6_33
Publication status	Published - 01-01-2017

All Science Journal Classification (ASJC) codes

Medicine(all)
Immunology and Microbiology(all)
Neuroscience(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-4939-7290-6_33

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N2 - This chapter reviews the roles of HIV-1 proteins in the neuropathogenesis and cognitive decline that occur in HIV-1-infected individuals. HIV-1 protein hydrophobic patterns and propensity to form secondary structures are addressed in conjunction with predicted amyloidogenic determinants for HIV-1 brain isolates. Their corresponding β-strand intermolecular pairing is also addressed. A comparative analysis with reference sequences is done to identify and confirm analogous properties and intrinsic factors. The predicted patterns and their sequence variation may serve to identify common features shared by amyloid fibrils that facilitate and enhance viral infectivity and an association with tissue damage.

AB - This chapter reviews the roles of HIV-1 proteins in the neuropathogenesis and cognitive decline that occur in HIV-1-infected individuals. HIV-1 protein hydrophobic patterns and propensity to form secondary structures are addressed in conjunction with predicted amyloidogenic determinants for HIV-1 brain isolates. Their corresponding β-strand intermolecular pairing is also addressed. A comparative analysis with reference sequences is done to identify and confirm analogous properties and intrinsic factors. The predicted patterns and their sequence variation may serve to identify common features shared by amyloid fibrils that facilitate and enhance viral infectivity and an association with tissue damage.

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BT - Global Virology II - HIV and NeuroAIDS

PB - Springer New York

ER -

Amyloidogenic pattern prediction of HIV-1 proteins

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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