This chapter reviews the roles of HIV-1 proteins in the neuropathogenesis and cognitive decline that occur in HIV-1-infected individuals. HIV-1 protein hydrophobic patterns and propensity to form secondary structures are addressed in conjunction with predicted amyloidogenic determinants for HIV-1 brain isolates. Their corresponding β-strand intermolecular pairing is also addressed. A comparative analysis with reference sequences is done to identify and confirm analogous properties and intrinsic factors. The predicted patterns and their sequence variation may serve to identify common features shared by amyloid fibrils that facilitate and enhance viral infectivity and an association with tissue damage.
All Science Journal Classification (ASJC) codes
- Immunology and Microbiology(all)