An appraisal of the healing profiles of oral and external (gel) metronidazole on partial thickness burn wounds

C. Mallikarjuna Rao, K. Mathew George, K. L. Bairy, S. N. Somayaji

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: To assess the influence of oral and topical (gel) metronidazole on partial thickness thermal burn wound healing. Methods: Partial thickness burn wounds were produced on dorsum of rats by pouring hot molten wax at 80°C. Oral and two topical gel (MGEL-1 and MGEL-2) preparations of metronidazole or their corresponding vehicles were administered to different groups of wound bearing animals. The effects of the treatments were compared by periodically observing wound contraction and epithelization and histological features as indicative of the progress of healing. Results: Healing of burn wounds was significantly promoted by oral metronidazole (p<0.01) and the gel base of MGEL-2. In contrast, the MGEL-1 significantly (p<0.05) depressed the epithelization process while its base was without effect, indicating that topical metronidazole retards healing. The effect of MGEL-2 appeared to be an algebraic sum of pro- and anti-healing effects of the base and drug respectively more in favour of the base (p<0.05). Conclusion: Metronidazole orally promotes but topically depresses healing of burn wounds. The latter effect can be reversed if the base has pro-healing property.

Original languageEnglish
Pages (from-to)282-287
Number of pages6
JournalIndian Journal of Pharmacology
Volume32
Issue number5
Publication statusPublished - 2000

Fingerprint

Metronidazole
Gels
Wound Healing
Wounds and Injuries
Waxes
Hot Temperature
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

@article{26a0c481a0e840b5b18caffa70f8366d,
title = "An appraisal of the healing profiles of oral and external (gel) metronidazole on partial thickness burn wounds",
abstract = "Objective: To assess the influence of oral and topical (gel) metronidazole on partial thickness thermal burn wound healing. Methods: Partial thickness burn wounds were produced on dorsum of rats by pouring hot molten wax at 80°C. Oral and two topical gel (MGEL-1 and MGEL-2) preparations of metronidazole or their corresponding vehicles were administered to different groups of wound bearing animals. The effects of the treatments were compared by periodically observing wound contraction and epithelization and histological features as indicative of the progress of healing. Results: Healing of burn wounds was significantly promoted by oral metronidazole (p<0.01) and the gel base of MGEL-2. In contrast, the MGEL-1 significantly (p<0.05) depressed the epithelization process while its base was without effect, indicating that topical metronidazole retards healing. The effect of MGEL-2 appeared to be an algebraic sum of pro- and anti-healing effects of the base and drug respectively more in favour of the base (p<0.05). Conclusion: Metronidazole orally promotes but topically depresses healing of burn wounds. The latter effect can be reversed if the base has pro-healing property.",
author = "Rao, {C. Mallikarjuna} and George, {K. Mathew} and Bairy, {K. L.} and Somayaji, {S. N.}",
year = "2000",
language = "English",
volume = "32",
pages = "282--287",
journal = "Indian Journal of Pharmacology",
issn = "0253-7613",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "5",

}

An appraisal of the healing profiles of oral and external (gel) metronidazole on partial thickness burn wounds. / Rao, C. Mallikarjuna; George, K. Mathew; Bairy, K. L.; Somayaji, S. N.

In: Indian Journal of Pharmacology, Vol. 32, No. 5, 2000, p. 282-287.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An appraisal of the healing profiles of oral and external (gel) metronidazole on partial thickness burn wounds

AU - Rao, C. Mallikarjuna

AU - George, K. Mathew

AU - Bairy, K. L.

AU - Somayaji, S. N.

PY - 2000

Y1 - 2000

N2 - Objective: To assess the influence of oral and topical (gel) metronidazole on partial thickness thermal burn wound healing. Methods: Partial thickness burn wounds were produced on dorsum of rats by pouring hot molten wax at 80°C. Oral and two topical gel (MGEL-1 and MGEL-2) preparations of metronidazole or their corresponding vehicles were administered to different groups of wound bearing animals. The effects of the treatments were compared by periodically observing wound contraction and epithelization and histological features as indicative of the progress of healing. Results: Healing of burn wounds was significantly promoted by oral metronidazole (p<0.01) and the gel base of MGEL-2. In contrast, the MGEL-1 significantly (p<0.05) depressed the epithelization process while its base was without effect, indicating that topical metronidazole retards healing. The effect of MGEL-2 appeared to be an algebraic sum of pro- and anti-healing effects of the base and drug respectively more in favour of the base (p<0.05). Conclusion: Metronidazole orally promotes but topically depresses healing of burn wounds. The latter effect can be reversed if the base has pro-healing property.

AB - Objective: To assess the influence of oral and topical (gel) metronidazole on partial thickness thermal burn wound healing. Methods: Partial thickness burn wounds were produced on dorsum of rats by pouring hot molten wax at 80°C. Oral and two topical gel (MGEL-1 and MGEL-2) preparations of metronidazole or their corresponding vehicles were administered to different groups of wound bearing animals. The effects of the treatments were compared by periodically observing wound contraction and epithelization and histological features as indicative of the progress of healing. Results: Healing of burn wounds was significantly promoted by oral metronidazole (p<0.01) and the gel base of MGEL-2. In contrast, the MGEL-1 significantly (p<0.05) depressed the epithelization process while its base was without effect, indicating that topical metronidazole retards healing. The effect of MGEL-2 appeared to be an algebraic sum of pro- and anti-healing effects of the base and drug respectively more in favour of the base (p<0.05). Conclusion: Metronidazole orally promotes but topically depresses healing of burn wounds. The latter effect can be reversed if the base has pro-healing property.

UR - http://www.scopus.com/inward/record.url?scp=0033767366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033767366&partnerID=8YFLogxK

M3 - Article

VL - 32

SP - 282

EP - 287

JO - Indian Journal of Pharmacology

JF - Indian Journal of Pharmacology

SN - 0253-7613

IS - 5

ER -