An evaluation of diuretic activity of Morinda citrifolia (Linn) (Noni) fruit juice in normal rats

Jnaneshwar P. Shenoy, Preethi G. Pai, Ahsan Shoeb, P. Gokul, Avdhoot Kulkarni, M. S. Kotian

Research output: Contribution to journalArticle

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Abstract

Morinda citrifolia (Noni fruit) juice, a proven antioxidant when evaluated for nephroprotective effects in a murine model was noted to produce a high volume of urine formation. Hence it was evaluated for its diuretic potential in normal rats. The study was conducted in saline primed Wistar albino rats (n=6) using frusemide (10 mg/kg) as the reference diuretic drug with two oral doses, 5mg/kg and 10mg/kg respectively. Urine volume and electrolytes (Sodium, Potassium and Chloride) excretion was estimated at the end of 24 hours and data was analyzed by Kruskall Wallis and Mann Whitney tests. P<0.05 was considered as statistically significant. Noni fruit juice statistically increased the volume of urine (6.82 ±1.18ml/100g/24hr and 7.87±1.15ml/100gm/24hr) in a dose dependent manner increasing the diuretic index to 2.04 and 2.36 for 5ml.kg and 10ml/kg dose ranges respectively. However, there was a statistical significant decrease in sodium ion excretion (70.1±14.3 m.mol/L at 5ml/kg and 41.97±9.3 m.mol/L at 10ml/kg) when compared to the control (107±5.18 m.mol/L). Though there was a similar decrease in potassium excretion it was not statistically significant. These findings indicate that the probable increase in urine formation might be due an aquaretic action of Noni fruit rather than a natruretic effect and further studies with larger doses and longer duration are warranted.

Original languageEnglish
Pages (from-to)119-121
Number of pages3
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume3
Issue number2
Publication statusPublished - 18-05-2011

Fingerprint

Morinda
Diuretics
Urine
Potassium Chloride
Furosemide
Sodium Chloride
Electrolytes
Wistar Rats
Fruit
Potassium
Antioxidants
Sodium
Ions
Fruit and Vegetable Juices
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Shenoy, Jnaneshwar P. ; Pai, Preethi G. ; Shoeb, Ahsan ; Gokul, P. ; Kulkarni, Avdhoot ; Kotian, M. S. / An evaluation of diuretic activity of Morinda citrifolia (Linn) (Noni) fruit juice in normal rats. In: International Journal of Pharmacy and Pharmaceutical Sciences. 2011 ; Vol. 3, No. 2. pp. 119-121.
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An evaluation of diuretic activity of Morinda citrifolia (Linn) (Noni) fruit juice in normal rats. / Shenoy, Jnaneshwar P.; Pai, Preethi G.; Shoeb, Ahsan; Gokul, P.; Kulkarni, Avdhoot; Kotian, M. S.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 3, No. 2, 18.05.2011, p. 119-121.

Research output: Contribution to journalArticle

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