An evaluation of the wound healing and anti-microbial property of the tincture of Lantana camara

Vinay Kumar, Adarsh Preet Kaur, V. K. Uma, Ravi Kumar, K. E. Vandana, Veena Nayak

Research output: Contribution to journalArticle

Abstract

Objective: Lantana camaraL (L. c) has been known for its anti-bacterial activity since quite some time in its various extracts and pharmacological preparations. In view of this, we plan to study and compare the wound healing property of tincture of L. cin surgically induced wound in animal models with tincture of iodine (I2). Methods: An herbal tincture was developed from stems of L. cin concentrations of 20%, 40%, alcohol in tincture was followed as mentioned in IP, tested against tincture I2 in same aged different groups of rats under incision and excision models, also with commonly wound infecting bacteria like S. aureus, E. coli, E. fecalis, P. aeruginosa. Wounds were induced surgically under anaesthesia. Excised rats were observed for wound contraction and epithelialisation. On 7th day, incised rats were subjected to wound dehiscence test. Tissue biopsy took on day 5, 14 and21 for histopathological studies. Results: Both test groups were found statistically significant against standard with P<0.05 and with mean epithelialisation day value 11±1.02 in the excision model and P<0.05 between the groups in incision model depicting 20% tincture as better with a mean value of 366.67±47.2. Histologically 40% tincture was found non-inferior against standard. Tincture was active against mentioned microbes in various dilutions. Conclusion: Tincture L. c was non-inferior to iodine. Further studies with concentrated extracts of L. cmay reveal its accelerated healing and better anti-microbial competency so that it can be developed for clinical practice.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume7
Issue number5
Publication statusPublished - 01-01-2015

Fingerprint

Lantana
Wound Healing
Wounds and Injuries
Iodine
Re-Epithelialization
Anesthesia
Animal Models
Alcohols
Pharmacology
Escherichia coli
Bacteria
Biopsy

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

@article{0ac189f18e454eca8d8a2643d7358727,
title = "An evaluation of the wound healing and anti-microbial property of the tincture of Lantana camara",
abstract = "Objective: Lantana camaraL (L. c) has been known for its anti-bacterial activity since quite some time in its various extracts and pharmacological preparations. In view of this, we plan to study and compare the wound healing property of tincture of L. cin surgically induced wound in animal models with tincture of iodine (I2). Methods: An herbal tincture was developed from stems of L. cin concentrations of 20{\%}, 40{\%}, alcohol in tincture was followed as mentioned in IP, tested against tincture I2 in same aged different groups of rats under incision and excision models, also with commonly wound infecting bacteria like S. aureus, E. coli, E. fecalis, P. aeruginosa. Wounds were induced surgically under anaesthesia. Excised rats were observed for wound contraction and epithelialisation. On 7th day, incised rats were subjected to wound dehiscence test. Tissue biopsy took on day 5, 14 and21 for histopathological studies. Results: Both test groups were found statistically significant against standard with P<0.05 and with mean epithelialisation day value 11±1.02 in the excision model and P<0.05 between the groups in incision model depicting 20{\%} tincture as better with a mean value of 366.67±47.2. Histologically 40{\%} tincture was found non-inferior against standard. Tincture was active against mentioned microbes in various dilutions. Conclusion: Tincture L. c was non-inferior to iodine. Further studies with concentrated extracts of L. cmay reveal its accelerated healing and better anti-microbial competency so that it can be developed for clinical practice.",
author = "Vinay Kumar and Kaur, {Adarsh Preet} and Uma, {V. K.} and Ravi Kumar and Vandana, {K. E.} and Veena Nayak",
year = "2015",
month = "1",
day = "1",
language = "English",
volume = "7",
pages = "313--316",
journal = "International Journal of Pharmacy and Pharmaceutical Sciences",
issn = "0975-1491",
publisher = "IJPPS",
number = "5",

}

An evaluation of the wound healing and anti-microbial property of the tincture of Lantana camara. / Kumar, Vinay; Kaur, Adarsh Preet; Uma, V. K.; Kumar, Ravi; Vandana, K. E.; Nayak, Veena.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, No. 5, 01.01.2015, p. 313-316.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An evaluation of the wound healing and anti-microbial property of the tincture of Lantana camara

AU - Kumar, Vinay

AU - Kaur, Adarsh Preet

AU - Uma, V. K.

AU - Kumar, Ravi

AU - Vandana, K. E.

AU - Nayak, Veena

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective: Lantana camaraL (L. c) has been known for its anti-bacterial activity since quite some time in its various extracts and pharmacological preparations. In view of this, we plan to study and compare the wound healing property of tincture of L. cin surgically induced wound in animal models with tincture of iodine (I2). Methods: An herbal tincture was developed from stems of L. cin concentrations of 20%, 40%, alcohol in tincture was followed as mentioned in IP, tested against tincture I2 in same aged different groups of rats under incision and excision models, also with commonly wound infecting bacteria like S. aureus, E. coli, E. fecalis, P. aeruginosa. Wounds were induced surgically under anaesthesia. Excised rats were observed for wound contraction and epithelialisation. On 7th day, incised rats were subjected to wound dehiscence test. Tissue biopsy took on day 5, 14 and21 for histopathological studies. Results: Both test groups were found statistically significant against standard with P<0.05 and with mean epithelialisation day value 11±1.02 in the excision model and P<0.05 between the groups in incision model depicting 20% tincture as better with a mean value of 366.67±47.2. Histologically 40% tincture was found non-inferior against standard. Tincture was active against mentioned microbes in various dilutions. Conclusion: Tincture L. c was non-inferior to iodine. Further studies with concentrated extracts of L. cmay reveal its accelerated healing and better anti-microbial competency so that it can be developed for clinical practice.

AB - Objective: Lantana camaraL (L. c) has been known for its anti-bacterial activity since quite some time in its various extracts and pharmacological preparations. In view of this, we plan to study and compare the wound healing property of tincture of L. cin surgically induced wound in animal models with tincture of iodine (I2). Methods: An herbal tincture was developed from stems of L. cin concentrations of 20%, 40%, alcohol in tincture was followed as mentioned in IP, tested against tincture I2 in same aged different groups of rats under incision and excision models, also with commonly wound infecting bacteria like S. aureus, E. coli, E. fecalis, P. aeruginosa. Wounds were induced surgically under anaesthesia. Excised rats were observed for wound contraction and epithelialisation. On 7th day, incised rats were subjected to wound dehiscence test. Tissue biopsy took on day 5, 14 and21 for histopathological studies. Results: Both test groups were found statistically significant against standard with P<0.05 and with mean epithelialisation day value 11±1.02 in the excision model and P<0.05 between the groups in incision model depicting 20% tincture as better with a mean value of 366.67±47.2. Histologically 40% tincture was found non-inferior against standard. Tincture was active against mentioned microbes in various dilutions. Conclusion: Tincture L. c was non-inferior to iodine. Further studies with concentrated extracts of L. cmay reveal its accelerated healing and better anti-microbial competency so that it can be developed for clinical practice.

UR - http://www.scopus.com/inward/record.url?scp=84929468546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929468546&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 313

EP - 316

JO - International Journal of Pharmacy and Pharmaceutical Sciences

JF - International Journal of Pharmacy and Pharmaceutical Sciences

SN - 0975-1491

IS - 5

ER -