An experimental study of the anticonvulsant effect of amlodipine in mice

K. N. Sathyanarayana Rao, N. K. Subbalakshmi

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Abstract

Introduction: The need for the rational development of newer and adjuvant drugs to treat epilepsy has prompted this study of the potential anticonvulsant effect of amlodipine. Methods: The acute effect was studied in mice in single doses of 1 mg/kg, 2 mg/kg and 4 mg/kg of amlodipine and the chronic effect was studied in doses of 1 mg/kg and 4 mg/kg (administered daily for 21 days) using the maximal electroshock seizure and pentylenetetrazole-induced seizure models of epilepsy. Sodium valproate and normal saline were used as the standard and control, respectively. Results: For the acute study, in the maximal electroshock seizure model, the administration of 1 mg/kg of amlodipine resulted in the complete abolition of seizures in 33 percent of the mice, and this was increased to 67 percent with the administration of 4 mg/kg. In the pentylenetetrazole-induced seizure model, the administration of 1 mg/kg and 2 mg/kg amlodipine protected 33 percent of the animals from mortality, and 67 percent were protected with the administration of 4 mg/kg. For the chronic study, in the maximal electroshock seizure model, the administration of 1 mg/kg amlodipine resulted in the complete abolition of seizures in 40 percent of the mice and in 60 percent, with the administration of 4 mg/kg. In the pentylenetetrazole-induced seizure model, 50 percent of the mice were protected from mortality with 1 mg/kg amlodipine and 60 percent, with 4 mg/kg amlodipine. Conclusion: These f indings indicate that amlodipine may be a good candidate as an add-on therapy for epilepsy.

Original languageEnglish
Pages (from-to)424-428
Number of pages5
JournalSingapore Medical Journal
Volume51
Issue number5
Publication statusPublished - 01-05-2010
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Sathyanarayana Rao, K. N., & Subbalakshmi, N. K. (2010). An experimental study of the anticonvulsant effect of amlodipine in mice. Singapore Medical Journal, 51(5), 424-428.