An infant with chronic severe neutropenia

Ramesh Y. Bhat, Chaitanya P V Varma, Sonia Bhatt

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Abstract

Neutropenia in infancy and childhood poses a diagnostic challenge as the aetiology ranges from acute life-threatening conditions to chronic benign diseases. Chronic benign neutropenia of infancy is a rare disorder occurring in 1:100 000. The neutrophil count continues to be low for a prolonged period until spontaneous resolution by the age of 3-4 years. Such infants are having higher incidences of minor infections requiring treatment with antibiotics and rare incidences of meningitis and sepsis. The authors describe an infant presenting with fever and cervical lymphadenitis, who was found to have isolated severe neutropenia and its persistence posing a diagnostic challenge. The prolonged course with minor infections and absence of serious underlying conditions finally confirmed chronic benign neutropenia of infancy.

Original languageEnglish
JournalBMJ Case Reports
DOIs
Publication statusPublished - 07-04-2014

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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