An infant with chronic severe neutropenia

Ramesh Y. Bhat, Chaitanya P V Varma, Sonia Bhatt

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Neutropenia in infancy and childhood poses a diagnostic challenge as the aetiology ranges from acute life-threatening conditions to chronic benign diseases. Chronic benign neutropenia of infancy is a rare disorder occurring in 1:100 000. The neutrophil count continues to be low for a prolonged period until spontaneous resolution by the age of 3-4 years. Such infants are having higher incidences of minor infections requiring treatment with antibiotics and rare incidences of meningitis and sepsis. The authors describe an infant presenting with fever and cervical lymphadenitis, who was found to have isolated severe neutropenia and its persistence posing a diagnostic challenge. The prolonged course with minor infections and absence of serious underlying conditions finally confirmed chronic benign neutropenia of infancy.

Original languageEnglish
JournalBMJ Case Reports
DOIs
Publication statusPublished - 07-04-2014

Fingerprint

Neutropenia
Lymphadenitis
Incidence
Infection
Meningitis
Sepsis
Neutrophils
Chronic Disease
Fever
Anti-Bacterial Agents
Severe chronic Neutropenia
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Bhat, Ramesh Y. ; Varma, Chaitanya P V ; Bhatt, Sonia. / An infant with chronic severe neutropenia. In: BMJ Case Reports. 2014.
@article{cd849622c7d44556a2f29e8d83862997,
title = "An infant with chronic severe neutropenia",
abstract = "Neutropenia in infancy and childhood poses a diagnostic challenge as the aetiology ranges from acute life-threatening conditions to chronic benign diseases. Chronic benign neutropenia of infancy is a rare disorder occurring in 1:100 000. The neutrophil count continues to be low for a prolonged period until spontaneous resolution by the age of 3-4 years. Such infants are having higher incidences of minor infections requiring treatment with antibiotics and rare incidences of meningitis and sepsis. The authors describe an infant presenting with fever and cervical lymphadenitis, who was found to have isolated severe neutropenia and its persistence posing a diagnostic challenge. The prolonged course with minor infections and absence of serious underlying conditions finally confirmed chronic benign neutropenia of infancy.",
author = "Bhat, {Ramesh Y.} and Varma, {Chaitanya P V} and Sonia Bhatt",
year = "2014",
month = "4",
day = "7",
doi = "10.1136/bcr-2013-202908",
language = "English",
journal = "BMJ Case Reports",
issn = "1757-790X",
publisher = "BMJ Publishing Group",

}

An infant with chronic severe neutropenia. / Bhat, Ramesh Y.; Varma, Chaitanya P V; Bhatt, Sonia.

In: BMJ Case Reports, 07.04.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An infant with chronic severe neutropenia

AU - Bhat, Ramesh Y.

AU - Varma, Chaitanya P V

AU - Bhatt, Sonia

PY - 2014/4/7

Y1 - 2014/4/7

N2 - Neutropenia in infancy and childhood poses a diagnostic challenge as the aetiology ranges from acute life-threatening conditions to chronic benign diseases. Chronic benign neutropenia of infancy is a rare disorder occurring in 1:100 000. The neutrophil count continues to be low for a prolonged period until spontaneous resolution by the age of 3-4 years. Such infants are having higher incidences of minor infections requiring treatment with antibiotics and rare incidences of meningitis and sepsis. The authors describe an infant presenting with fever and cervical lymphadenitis, who was found to have isolated severe neutropenia and its persistence posing a diagnostic challenge. The prolonged course with minor infections and absence of serious underlying conditions finally confirmed chronic benign neutropenia of infancy.

AB - Neutropenia in infancy and childhood poses a diagnostic challenge as the aetiology ranges from acute life-threatening conditions to chronic benign diseases. Chronic benign neutropenia of infancy is a rare disorder occurring in 1:100 000. The neutrophil count continues to be low for a prolonged period until spontaneous resolution by the age of 3-4 years. Such infants are having higher incidences of minor infections requiring treatment with antibiotics and rare incidences of meningitis and sepsis. The authors describe an infant presenting with fever and cervical lymphadenitis, who was found to have isolated severe neutropenia and its persistence posing a diagnostic challenge. The prolonged course with minor infections and absence of serious underlying conditions finally confirmed chronic benign neutropenia of infancy.

UR - http://www.scopus.com/inward/record.url?scp=84899619917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899619917&partnerID=8YFLogxK

U2 - 10.1136/bcr-2013-202908

DO - 10.1136/bcr-2013-202908

M3 - Article

JO - BMJ Case Reports

JF - BMJ Case Reports

SN - 1757-790X

ER -