An insight in to the efficacy of dehydrozingerone against aluminium induced cognitive dysfunction in rats

Research output: Contribution to journalArticle

Abstract

Recent literatures favour the use of curcumin and its structural analogues in neurodegenerative disorders. The poor bioavailability of curcumin is a limitation to its ability to halt neurodegeneration. Thus the objective of our study was to assess the role of dehydrozingerone (DHZ), half analogue of curcumin in aluminium chloride induced cognitive dysfunction model in rats. The effects of two prophylactic doses of DHZ viz., 100mg/kg and 200mg/kg were assessed in aluminium treated rats by Morris water maze test. Aluminium treated rats showed decreased performance in the Morris water maze test. Rats treated with DHZ did not show improvement in cognition function in acquisition trials. The present study shows that prophylactic administration of DHZ (100mg/kg and 200mg/kg) did not improve the learning abilities against aluminium induced cognitive dysfunction in rats.

Original languageEnglish
Article number15
Pages (from-to)70-73
Number of pages4
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume39
Issue number1
Publication statusPublished - 01-07-2016

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Aluminum
Curcumin
Aptitude
Water
Neurodegenerative Diseases
Cognition
Biological Availability
Cognitive Dysfunction
methyl-3-methoxy-4-hydroxystyryl ketone
Learning

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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abstract = "Recent literatures favour the use of curcumin and its structural analogues in neurodegenerative disorders. The poor bioavailability of curcumin is a limitation to its ability to halt neurodegeneration. Thus the objective of our study was to assess the role of dehydrozingerone (DHZ), half analogue of curcumin in aluminium chloride induced cognitive dysfunction model in rats. The effects of two prophylactic doses of DHZ viz., 100mg/kg and 200mg/kg were assessed in aluminium treated rats by Morris water maze test. Aluminium treated rats showed decreased performance in the Morris water maze test. Rats treated with DHZ did not show improvement in cognition function in acquisition trials. The present study shows that prophylactic administration of DHZ (100mg/kg and 200mg/kg) did not improve the learning abilities against aluminium induced cognitive dysfunction in rats.",
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