An International Multicenter Study Assessing the Role of Ethnicity on Variation of Lumbar Facet Joint Orientation and the Occurrence of Degenerative Spondylolisthesis in Asia Pacific

A Study from the AOSpine Asia Pacific Research Collaboration Consortium

Richard Williams, Jason Pui Yin Cheung, Ben Goss, Shanmuganathan Rajasekaran, Yoshiharu Kawaguchi, Shankar Acharya, Mamoru Kawakami, Shigenobu Satoh, Wen Jer Chen, Chun Kun Park, Chong Suh Lee, Thanit Foocharoen, Hideki Nagashima, Sunguk Kuh, Zhaomin Zheng, Richard Condor, Manabu Ito, Motoki Iwasaki, Je Hoon Jeong, Keith D.K. Luk & 18 others Bambang Prijambodo, Amol Rege, Tae Ahn Jahng, Zhuojing Luo, Warat Tassanawipas, Narayana Acharya, Rohit Pokharel, Yong Shen, Takui Ito, Zhihai Zhang, Aithala P. Janardhana, Gomatam Vijay Kumar, Rahyussalim Ahmad Jabir, Saumyajit Basu, Baojun Li, Vishal Moudgil, Phoebe Sham, Dino Samartzis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Study Design A multinational, multiethnic, cross-sectional image-based study was performed in 33 institutions, representing 10 countries, which were part of the AOSpine Asia Pacific Research Collaboration Consortium. Objective Lumbar facet joint orientation has been reported to be associated with the development of degenerative spondylolisthesis (DS). The role of ethnicity regarding facet joint orientation remains uncertain. As such, the following study was performed across a wide-ranging population base to assess the role of ethnicity in facet joint orientation in patients with DS in the Asia Pacific region. Methods Lateral standing X-rays and axial magnetic resonance imaging scans were obtained for patients with lumbar DS. The DS parameters and facet joint angulations were assessed from L3-S1. Sex, age, body mass index (BMI), and ethnicity were also noted. Results The study included 371 patients with known ethnic origin (mean age: 62.0 years; 64% males, 36% females). The mean BMI was 25.6 kg/m2. The level of DS was most prevalent at L4-L5 (74.7%). There were 28.8% Indian, 28.6% Japanese, 18.1% Chinese, 8.6% Korean, 6.5% Thai, 4.9% Caucasian, 2.7% Filipino, and 1.9% Malay patients. Variations in facet joint angulations were noted from L3 to S1 and between patients with and without DS (p < 0.05). No differences were noted with regards to sex and overall BMI to facet joint angulations (p > 0.05); however, increasing age was found to increase the degree of angulation throughout the lumbar spine (p < 0.05). Accounting for age and the presence or absence of DS at each level, no statistically significant differences between ethnicity and degree of facet joint angulations from L3-L5 were noted (p > 0.05). Ethnic variations were noted in non-DS L5-S1 facet joint angulations, predominantly between Caucasian, Chinese, and Indian ethnicities (p < 0.05). Conclusions This study is the first to suggest that ethnicity may not play a role in facet joint orientation in the majority of cases of DS in the Asia-Pacific region. Findings from this study may facilitate future comparative studies in other multiethnic populations. An understanding of ethnic variability may assist in identifying those patients at risk of postsurgical development or progression of DS. This study also serves as a model for large-scale multicenter studies across different ethnic groups and cultural boundaries in Asia.

Original languageEnglish
Pages (from-to)35-45
Number of pages11
JournalGlobal Spine Journal
Volume6
Issue number1
DOIs
Publication statusPublished - 26-03-2015
Externally publishedYes

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Zygapophyseal Joint
Spondylolisthesis
Multicenter Studies
Research
Body Mass Index
Ethnic Groups
Population
Spine
Magnetic Resonance Imaging
X-Rays

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Williams, Richard ; Cheung, Jason Pui Yin ; Goss, Ben ; Rajasekaran, Shanmuganathan ; Kawaguchi, Yoshiharu ; Acharya, Shankar ; Kawakami, Mamoru ; Satoh, Shigenobu ; Chen, Wen Jer ; Park, Chun Kun ; Lee, Chong Suh ; Foocharoen, Thanit ; Nagashima, Hideki ; Kuh, Sunguk ; Zheng, Zhaomin ; Condor, Richard ; Ito, Manabu ; Iwasaki, Motoki ; Jeong, Je Hoon ; Luk, Keith D.K. ; Prijambodo, Bambang ; Rege, Amol ; Jahng, Tae Ahn ; Luo, Zhuojing ; Tassanawipas, Warat ; Acharya, Narayana ; Pokharel, Rohit ; Shen, Yong ; Ito, Takui ; Zhang, Zhihai ; Janardhana, Aithala P. ; Kumar, Gomatam Vijay ; Jabir, Rahyussalim Ahmad ; Basu, Saumyajit ; Li, Baojun ; Moudgil, Vishal ; Sham, Phoebe ; Samartzis, Dino. / An International Multicenter Study Assessing the Role of Ethnicity on Variation of Lumbar Facet Joint Orientation and the Occurrence of Degenerative Spondylolisthesis in Asia Pacific : A Study from the AOSpine Asia Pacific Research Collaboration Consortium. In: Global Spine Journal. 2015 ; Vol. 6, No. 1. pp. 35-45.
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title = "An International Multicenter Study Assessing the Role of Ethnicity on Variation of Lumbar Facet Joint Orientation and the Occurrence of Degenerative Spondylolisthesis in Asia Pacific: A Study from the AOSpine Asia Pacific Research Collaboration Consortium",
abstract = "Study Design A multinational, multiethnic, cross-sectional image-based study was performed in 33 institutions, representing 10 countries, which were part of the AOSpine Asia Pacific Research Collaboration Consortium. Objective Lumbar facet joint orientation has been reported to be associated with the development of degenerative spondylolisthesis (DS). The role of ethnicity regarding facet joint orientation remains uncertain. As such, the following study was performed across a wide-ranging population base to assess the role of ethnicity in facet joint orientation in patients with DS in the Asia Pacific region. Methods Lateral standing X-rays and axial magnetic resonance imaging scans were obtained for patients with lumbar DS. The DS parameters and facet joint angulations were assessed from L3-S1. Sex, age, body mass index (BMI), and ethnicity were also noted. Results The study included 371 patients with known ethnic origin (mean age: 62.0 years; 64{\%} males, 36{\%} females). The mean BMI was 25.6 kg/m2. The level of DS was most prevalent at L4-L5 (74.7{\%}). There were 28.8{\%} Indian, 28.6{\%} Japanese, 18.1{\%} Chinese, 8.6{\%} Korean, 6.5{\%} Thai, 4.9{\%} Caucasian, 2.7{\%} Filipino, and 1.9{\%} Malay patients. Variations in facet joint angulations were noted from L3 to S1 and between patients with and without DS (p < 0.05). No differences were noted with regards to sex and overall BMI to facet joint angulations (p > 0.05); however, increasing age was found to increase the degree of angulation throughout the lumbar spine (p < 0.05). Accounting for age and the presence or absence of DS at each level, no statistically significant differences between ethnicity and degree of facet joint angulations from L3-L5 were noted (p > 0.05). Ethnic variations were noted in non-DS L5-S1 facet joint angulations, predominantly between Caucasian, Chinese, and Indian ethnicities (p < 0.05). Conclusions This study is the first to suggest that ethnicity may not play a role in facet joint orientation in the majority of cases of DS in the Asia-Pacific region. Findings from this study may facilitate future comparative studies in other multiethnic populations. An understanding of ethnic variability may assist in identifying those patients at risk of postsurgical development or progression of DS. This study also serves as a model for large-scale multicenter studies across different ethnic groups and cultural boundaries in Asia.",
author = "Richard Williams and Cheung, {Jason Pui Yin} and Ben Goss and Shanmuganathan Rajasekaran and Yoshiharu Kawaguchi and Shankar Acharya and Mamoru Kawakami and Shigenobu Satoh and Chen, {Wen Jer} and Park, {Chun Kun} and Lee, {Chong Suh} and Thanit Foocharoen and Hideki Nagashima and Sunguk Kuh and Zhaomin Zheng and Richard Condor and Manabu Ito and Motoki Iwasaki and Jeong, {Je Hoon} and Luk, {Keith D.K.} and Bambang Prijambodo and Amol Rege and Jahng, {Tae Ahn} and Zhuojing Luo and Warat Tassanawipas and Narayana Acharya and Rohit Pokharel and Yong Shen and Takui Ito and Zhihai Zhang and Janardhana, {Aithala P.} and Kumar, {Gomatam Vijay} and Jabir, {Rahyussalim Ahmad} and Saumyajit Basu and Baojun Li and Vishal Moudgil and Phoebe Sham and Dino Samartzis",
year = "2015",
month = "3",
day = "26",
doi = "10.1055/s-0035-1555655",
language = "English",
volume = "6",
pages = "35--45",
journal = "Global Spine Journal",
issn = "2192-5682",
publisher = "Thieme Medical Publishers",
number = "1",

}

Williams, R, Cheung, JPY, Goss, B, Rajasekaran, S, Kawaguchi, Y, Acharya, S, Kawakami, M, Satoh, S, Chen, WJ, Park, CK, Lee, CS, Foocharoen, T, Nagashima, H, Kuh, S, Zheng, Z, Condor, R, Ito, M, Iwasaki, M, Jeong, JH, Luk, KDK, Prijambodo, B, Rege, A, Jahng, TA, Luo, Z, Tassanawipas, W, Acharya, N, Pokharel, R, Shen, Y, Ito, T, Zhang, Z, Janardhana, AP, Kumar, GV, Jabir, RA, Basu, S, Li, B, Moudgil, V, Sham, P & Samartzis, D 2015, 'An International Multicenter Study Assessing the Role of Ethnicity on Variation of Lumbar Facet Joint Orientation and the Occurrence of Degenerative Spondylolisthesis in Asia Pacific: A Study from the AOSpine Asia Pacific Research Collaboration Consortium', Global Spine Journal, vol. 6, no. 1, pp. 35-45. https://doi.org/10.1055/s-0035-1555655

An International Multicenter Study Assessing the Role of Ethnicity on Variation of Lumbar Facet Joint Orientation and the Occurrence of Degenerative Spondylolisthesis in Asia Pacific : A Study from the AOSpine Asia Pacific Research Collaboration Consortium. / Williams, Richard; Cheung, Jason Pui Yin; Goss, Ben; Rajasekaran, Shanmuganathan; Kawaguchi, Yoshiharu; Acharya, Shankar; Kawakami, Mamoru; Satoh, Shigenobu; Chen, Wen Jer; Park, Chun Kun; Lee, Chong Suh; Foocharoen, Thanit; Nagashima, Hideki; Kuh, Sunguk; Zheng, Zhaomin; Condor, Richard; Ito, Manabu; Iwasaki, Motoki; Jeong, Je Hoon; Luk, Keith D.K.; Prijambodo, Bambang; Rege, Amol; Jahng, Tae Ahn; Luo, Zhuojing; Tassanawipas, Warat; Acharya, Narayana; Pokharel, Rohit; Shen, Yong; Ito, Takui; Zhang, Zhihai; Janardhana, Aithala P.; Kumar, Gomatam Vijay; Jabir, Rahyussalim Ahmad; Basu, Saumyajit; Li, Baojun; Moudgil, Vishal; Sham, Phoebe; Samartzis, Dino.

In: Global Spine Journal, Vol. 6, No. 1, 26.03.2015, p. 35-45.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An International Multicenter Study Assessing the Role of Ethnicity on Variation of Lumbar Facet Joint Orientation and the Occurrence of Degenerative Spondylolisthesis in Asia Pacific

T2 - A Study from the AOSpine Asia Pacific Research Collaboration Consortium

AU - Williams, Richard

AU - Cheung, Jason Pui Yin

AU - Goss, Ben

AU - Rajasekaran, Shanmuganathan

AU - Kawaguchi, Yoshiharu

AU - Acharya, Shankar

AU - Kawakami, Mamoru

AU - Satoh, Shigenobu

AU - Chen, Wen Jer

AU - Park, Chun Kun

AU - Lee, Chong Suh

AU - Foocharoen, Thanit

AU - Nagashima, Hideki

AU - Kuh, Sunguk

AU - Zheng, Zhaomin

AU - Condor, Richard

AU - Ito, Manabu

AU - Iwasaki, Motoki

AU - Jeong, Je Hoon

AU - Luk, Keith D.K.

AU - Prijambodo, Bambang

AU - Rege, Amol

AU - Jahng, Tae Ahn

AU - Luo, Zhuojing

AU - Tassanawipas, Warat

AU - Acharya, Narayana

AU - Pokharel, Rohit

AU - Shen, Yong

AU - Ito, Takui

AU - Zhang, Zhihai

AU - Janardhana, Aithala P.

AU - Kumar, Gomatam Vijay

AU - Jabir, Rahyussalim Ahmad

AU - Basu, Saumyajit

AU - Li, Baojun

AU - Moudgil, Vishal

AU - Sham, Phoebe

AU - Samartzis, Dino

PY - 2015/3/26

Y1 - 2015/3/26

N2 - Study Design A multinational, multiethnic, cross-sectional image-based study was performed in 33 institutions, representing 10 countries, which were part of the AOSpine Asia Pacific Research Collaboration Consortium. Objective Lumbar facet joint orientation has been reported to be associated with the development of degenerative spondylolisthesis (DS). The role of ethnicity regarding facet joint orientation remains uncertain. As such, the following study was performed across a wide-ranging population base to assess the role of ethnicity in facet joint orientation in patients with DS in the Asia Pacific region. Methods Lateral standing X-rays and axial magnetic resonance imaging scans were obtained for patients with lumbar DS. The DS parameters and facet joint angulations were assessed from L3-S1. Sex, age, body mass index (BMI), and ethnicity were also noted. Results The study included 371 patients with known ethnic origin (mean age: 62.0 years; 64% males, 36% females). The mean BMI was 25.6 kg/m2. The level of DS was most prevalent at L4-L5 (74.7%). There were 28.8% Indian, 28.6% Japanese, 18.1% Chinese, 8.6% Korean, 6.5% Thai, 4.9% Caucasian, 2.7% Filipino, and 1.9% Malay patients. Variations in facet joint angulations were noted from L3 to S1 and between patients with and without DS (p < 0.05). No differences were noted with regards to sex and overall BMI to facet joint angulations (p > 0.05); however, increasing age was found to increase the degree of angulation throughout the lumbar spine (p < 0.05). Accounting for age and the presence or absence of DS at each level, no statistically significant differences between ethnicity and degree of facet joint angulations from L3-L5 were noted (p > 0.05). Ethnic variations were noted in non-DS L5-S1 facet joint angulations, predominantly between Caucasian, Chinese, and Indian ethnicities (p < 0.05). Conclusions This study is the first to suggest that ethnicity may not play a role in facet joint orientation in the majority of cases of DS in the Asia-Pacific region. Findings from this study may facilitate future comparative studies in other multiethnic populations. An understanding of ethnic variability may assist in identifying those patients at risk of postsurgical development or progression of DS. This study also serves as a model for large-scale multicenter studies across different ethnic groups and cultural boundaries in Asia.

AB - Study Design A multinational, multiethnic, cross-sectional image-based study was performed in 33 institutions, representing 10 countries, which were part of the AOSpine Asia Pacific Research Collaboration Consortium. Objective Lumbar facet joint orientation has been reported to be associated with the development of degenerative spondylolisthesis (DS). The role of ethnicity regarding facet joint orientation remains uncertain. As such, the following study was performed across a wide-ranging population base to assess the role of ethnicity in facet joint orientation in patients with DS in the Asia Pacific region. Methods Lateral standing X-rays and axial magnetic resonance imaging scans were obtained for patients with lumbar DS. The DS parameters and facet joint angulations were assessed from L3-S1. Sex, age, body mass index (BMI), and ethnicity were also noted. Results The study included 371 patients with known ethnic origin (mean age: 62.0 years; 64% males, 36% females). The mean BMI was 25.6 kg/m2. The level of DS was most prevalent at L4-L5 (74.7%). There were 28.8% Indian, 28.6% Japanese, 18.1% Chinese, 8.6% Korean, 6.5% Thai, 4.9% Caucasian, 2.7% Filipino, and 1.9% Malay patients. Variations in facet joint angulations were noted from L3 to S1 and between patients with and without DS (p < 0.05). No differences were noted with regards to sex and overall BMI to facet joint angulations (p > 0.05); however, increasing age was found to increase the degree of angulation throughout the lumbar spine (p < 0.05). Accounting for age and the presence or absence of DS at each level, no statistically significant differences between ethnicity and degree of facet joint angulations from L3-L5 were noted (p > 0.05). Ethnic variations were noted in non-DS L5-S1 facet joint angulations, predominantly between Caucasian, Chinese, and Indian ethnicities (p < 0.05). Conclusions This study is the first to suggest that ethnicity may not play a role in facet joint orientation in the majority of cases of DS in the Asia-Pacific region. Findings from this study may facilitate future comparative studies in other multiethnic populations. An understanding of ethnic variability may assist in identifying those patients at risk of postsurgical development or progression of DS. This study also serves as a model for large-scale multicenter studies across different ethnic groups and cultural boundaries in Asia.

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U2 - 10.1055/s-0035-1555655

DO - 10.1055/s-0035-1555655

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JF - Global Spine Journal

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