An unusual case of hyponatremia causing rhabdomyolysis

Sneha Seshadri, Raghavendra Rao, Navin Patil, Shubha Seshadri, O. Balaji, Amita, Karthik Rao, Talha Ahmed

Research output: Contribution to journalArticle

Abstract

Rhabdomyolysis is a clinical condition characterized by muscle necrosis and the release of intracellular muscle contents into systemic circulation there by leading to asymptomatic elevation of serum muscle enzymes, electrolyte imbalances, and acute renal failure. Hyponatremia is one of the commonest of electrolyte disorder. Hyponatremia causing rhabdomyolysis is very rare and mechanisms are unknown. A thirty four year old male patient with complaints of recurrent vomiting, severe myalgia, generalized weakness and altered sensorium without history of headache, seizures and other co-morbid medical conditions presented to our emergency room. Vitals and systemic examination was normal. Laboratory investigations suggested Syndrome of Inappropriate Anti Diuretic Hormone (SIADH) leading to Rhabdomyolysis and was confirmed with muscle biopsy. Double strength saline and tolvaptan was administered and patient was discharged with improvement in serum sodium and creatine kinase levels. After 4 weeks patient recovered completely and urine hemoglobin was negative with normal creatine kinase levels. Hyponatremia being a rare cause of rhabdomyolysis monitoring of renal function and serum creatine kinase during hyponatremia is warranted. Futher studies are required to uncover the mechanisms underlying hyponatremia causing rhabdomyolysis. Vaptans can play a significant role in in managing rhabdomyolysis induced by hyponatremia with other supportive treatment measures.

Original languageEnglish
Pages (from-to)1658-1661
Number of pages4
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume7
Issue number1
Publication statusPublished - 01-01-2016

Fingerprint

Rhabdomyolysis
Hyponatremia
Muscle
Creatine Kinase
Electrolytes
Muscles
Emergency rooms
Biopsy
Serum
Hemoglobins
Sodium
Myalgia
Diuretics
Acute Kidney Injury
Vomiting
Headache
Hospital Emergency Service
Monitoring
Seizures
Necrosis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Seshadri, Sneha ; Rao, Raghavendra ; Patil, Navin ; Seshadri, Shubha ; Balaji, O. ; Amita ; Rao, Karthik ; Ahmed, Talha. / An unusual case of hyponatremia causing rhabdomyolysis. In: Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2016 ; Vol. 7, No. 1. pp. 1658-1661.
@article{d7b7bc5af3664c198a7e51058fff7fb4,
title = "An unusual case of hyponatremia causing rhabdomyolysis",
abstract = "Rhabdomyolysis is a clinical condition characterized by muscle necrosis and the release of intracellular muscle contents into systemic circulation there by leading to asymptomatic elevation of serum muscle enzymes, electrolyte imbalances, and acute renal failure. Hyponatremia is one of the commonest of electrolyte disorder. Hyponatremia causing rhabdomyolysis is very rare and mechanisms are unknown. A thirty four year old male patient with complaints of recurrent vomiting, severe myalgia, generalized weakness and altered sensorium without history of headache, seizures and other co-morbid medical conditions presented to our emergency room. Vitals and systemic examination was normal. Laboratory investigations suggested Syndrome of Inappropriate Anti Diuretic Hormone (SIADH) leading to Rhabdomyolysis and was confirmed with muscle biopsy. Double strength saline and tolvaptan was administered and patient was discharged with improvement in serum sodium and creatine kinase levels. After 4 weeks patient recovered completely and urine hemoglobin was negative with normal creatine kinase levels. Hyponatremia being a rare cause of rhabdomyolysis monitoring of renal function and serum creatine kinase during hyponatremia is warranted. Futher studies are required to uncover the mechanisms underlying hyponatremia causing rhabdomyolysis. Vaptans can play a significant role in in managing rhabdomyolysis induced by hyponatremia with other supportive treatment measures.",
author = "Sneha Seshadri and Raghavendra Rao and Navin Patil and Shubha Seshadri and O. Balaji and Amita and Karthik Rao and Talha Ahmed",
year = "2016",
month = "1",
day = "1",
language = "English",
volume = "7",
pages = "1658--1661",
journal = "Research Journal of Pharmaceutical, Biological and Chemical Sciences",
issn = "0975-8585",
publisher = "RJPBCS",
number = "1",

}

Seshadri, S, Rao, R, Patil, N, Seshadri, S, Balaji, O, Amita, Rao, K & Ahmed, T 2016, 'An unusual case of hyponatremia causing rhabdomyolysis', Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 7, no. 1, pp. 1658-1661.

An unusual case of hyponatremia causing rhabdomyolysis. / Seshadri, Sneha; Rao, Raghavendra; Patil, Navin; Seshadri, Shubha; Balaji, O.; Amita; Rao, Karthik; Ahmed, Talha.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 7, No. 1, 01.01.2016, p. 1658-1661.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An unusual case of hyponatremia causing rhabdomyolysis

AU - Seshadri, Sneha

AU - Rao, Raghavendra

AU - Patil, Navin

AU - Seshadri, Shubha

AU - Balaji, O.

AU - Amita,

AU - Rao, Karthik

AU - Ahmed, Talha

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Rhabdomyolysis is a clinical condition characterized by muscle necrosis and the release of intracellular muscle contents into systemic circulation there by leading to asymptomatic elevation of serum muscle enzymes, electrolyte imbalances, and acute renal failure. Hyponatremia is one of the commonest of electrolyte disorder. Hyponatremia causing rhabdomyolysis is very rare and mechanisms are unknown. A thirty four year old male patient with complaints of recurrent vomiting, severe myalgia, generalized weakness and altered sensorium without history of headache, seizures and other co-morbid medical conditions presented to our emergency room. Vitals and systemic examination was normal. Laboratory investigations suggested Syndrome of Inappropriate Anti Diuretic Hormone (SIADH) leading to Rhabdomyolysis and was confirmed with muscle biopsy. Double strength saline and tolvaptan was administered and patient was discharged with improvement in serum sodium and creatine kinase levels. After 4 weeks patient recovered completely and urine hemoglobin was negative with normal creatine kinase levels. Hyponatremia being a rare cause of rhabdomyolysis monitoring of renal function and serum creatine kinase during hyponatremia is warranted. Futher studies are required to uncover the mechanisms underlying hyponatremia causing rhabdomyolysis. Vaptans can play a significant role in in managing rhabdomyolysis induced by hyponatremia with other supportive treatment measures.

AB - Rhabdomyolysis is a clinical condition characterized by muscle necrosis and the release of intracellular muscle contents into systemic circulation there by leading to asymptomatic elevation of serum muscle enzymes, electrolyte imbalances, and acute renal failure. Hyponatremia is one of the commonest of electrolyte disorder. Hyponatremia causing rhabdomyolysis is very rare and mechanisms are unknown. A thirty four year old male patient with complaints of recurrent vomiting, severe myalgia, generalized weakness and altered sensorium without history of headache, seizures and other co-morbid medical conditions presented to our emergency room. Vitals and systemic examination was normal. Laboratory investigations suggested Syndrome of Inappropriate Anti Diuretic Hormone (SIADH) leading to Rhabdomyolysis and was confirmed with muscle biopsy. Double strength saline and tolvaptan was administered and patient was discharged with improvement in serum sodium and creatine kinase levels. After 4 weeks patient recovered completely and urine hemoglobin was negative with normal creatine kinase levels. Hyponatremia being a rare cause of rhabdomyolysis monitoring of renal function and serum creatine kinase during hyponatremia is warranted. Futher studies are required to uncover the mechanisms underlying hyponatremia causing rhabdomyolysis. Vaptans can play a significant role in in managing rhabdomyolysis induced by hyponatremia with other supportive treatment measures.

UR - http://www.scopus.com/inward/record.url?scp=84955265016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955265016&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 1658

EP - 1661

JO - Research Journal of Pharmaceutical, Biological and Chemical Sciences

JF - Research Journal of Pharmaceutical, Biological and Chemical Sciences

SN - 0975-8585

IS - 1

ER -