An unusual cause for hyponatremia with seizures.

Kushal Naha, G. Vivek, Sowjanya Dasari, M. Manthappa, Lorraine Dias, Raviraja Acharya

Research output: Contribution to journalArticle

Abstract

A 50-year-old Asian Indian female with known hypertension presented with persistent vomiting but no other symptoms of meningism. Clinical examination and basic laboratory parameters were entirely normal except for significant hyponatremia. Further investigation was suggestive of the syndrome of inappropriate antidiuretic hormone (SIADH) secretion. Subsequently, despite steady correction of hyponatremia, the patient developed generalised seizures. Cerebrospinal fluid (CSF) analysis performed was inconclusive. Screening for a chronic meningitis underlying SIADH, yielded positive blood and CSF titres for venereal disease research laboratory (VDRL), which were confirmed by Treponema pallidum haemagglutination (TPHA). The patient was treated for neurosyphilis and made a complete recovery. Hyponatremia resolved and she had no further episodes of seizures. She was tested for HIV infection which was negative. On follow-up, she remained TPHA positive but VDRL titres became negative.

Original languageEnglish
JournalBMJ Case Reports
Volume2012
Publication statusPublished - 01-12-2012

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Hyponatremia
Treponema pallidum
Seizures
Hemagglutination
Sexually Transmitted Diseases
Cerebrospinal Fluid
Meningism
Neurosyphilis
Inappropriate ADH Syndrome
Vasopressins
Meningitis
Research
HIV Infections
Vomiting
Hypertension

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Naha, K., Vivek, G., Dasari, S., Manthappa, M., Dias, L., & Acharya, R. (2012). An unusual cause for hyponatremia with seizures. BMJ Case Reports, 2012.
Naha, Kushal ; Vivek, G. ; Dasari, Sowjanya ; Manthappa, M. ; Dias, Lorraine ; Acharya, Raviraja. / An unusual cause for hyponatremia with seizures. In: BMJ Case Reports. 2012 ; Vol. 2012.
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Naha, K, Vivek, G, Dasari, S, Manthappa, M, Dias, L & Acharya, R 2012, 'An unusual cause for hyponatremia with seizures.', BMJ Case Reports, vol. 2012.

An unusual cause for hyponatremia with seizures. / Naha, Kushal; Vivek, G.; Dasari, Sowjanya; Manthappa, M.; Dias, Lorraine; Acharya, Raviraja.

In: BMJ Case Reports, Vol. 2012, 01.12.2012.

Research output: Contribution to journalArticle

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Naha K, Vivek G, Dasari S, Manthappa M, Dias L, Acharya R. An unusual cause for hyponatremia with seizures. BMJ Case Reports. 2012 Dec 1;2012.