An update on solubility enhancement methods for BCS class -II drugs

Research output: Contribution to journalReview article

Abstract

To attain the anticipated concentration of a drug in the systemic circulation in order to exhibit the pharmacologic response, solubility of the drug plays a critical role. Key research problems faced during formulation development of various drugs owe to their low aqueous solubility. About 40% of NCEs are unsuccessful in reaching their therapeutic range mainly due to their solubility issues. In this context, this review article details various solubility enhancement techniques and their application mainly to address this poor solubility of various BCS class-II drugs.

Original languageEnglish
Pages (from-to)48-57
Number of pages10
JournalJournal of Global Pharma Technology
Volume9
Issue number9
Publication statusPublished - 01-09-2017

Fingerprint

Solubility
Pharmaceutical Preparations
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

@article{760f07a345ed43cf933f20f1527ff3c6,
title = "An update on solubility enhancement methods for BCS class -II drugs",
abstract = "To attain the anticipated concentration of a drug in the systemic circulation in order to exhibit the pharmacologic response, solubility of the drug plays a critical role. Key research problems faced during formulation development of various drugs owe to their low aqueous solubility. About 40{\%} of NCEs are unsuccessful in reaching their therapeutic range mainly due to their solubility issues. In this context, this review article details various solubility enhancement techniques and their application mainly to address this poor solubility of various BCS class-II drugs.",
author = "Shaik Naaz and Tippavajhala, {Vamshi Krishna}",
year = "2017",
month = "9",
day = "1",
language = "English",
volume = "9",
pages = "48--57",
journal = "Journal of Global Pharma Technology",
issn = "0975-8542",
publisher = "Journal of Global Pharma Technology",
number = "9",

}

An update on solubility enhancement methods for BCS class -II drugs. / Naaz, Shaik; Tippavajhala, Vamshi Krishna.

In: Journal of Global Pharma Technology, Vol. 9, No. 9, 01.09.2017, p. 48-57.

Research output: Contribution to journalReview article

TY - JOUR

T1 - An update on solubility enhancement methods for BCS class -II drugs

AU - Naaz, Shaik

AU - Tippavajhala, Vamshi Krishna

PY - 2017/9/1

Y1 - 2017/9/1

N2 - To attain the anticipated concentration of a drug in the systemic circulation in order to exhibit the pharmacologic response, solubility of the drug plays a critical role. Key research problems faced during formulation development of various drugs owe to their low aqueous solubility. About 40% of NCEs are unsuccessful in reaching their therapeutic range mainly due to their solubility issues. In this context, this review article details various solubility enhancement techniques and their application mainly to address this poor solubility of various BCS class-II drugs.

AB - To attain the anticipated concentration of a drug in the systemic circulation in order to exhibit the pharmacologic response, solubility of the drug plays a critical role. Key research problems faced during formulation development of various drugs owe to their low aqueous solubility. About 40% of NCEs are unsuccessful in reaching their therapeutic range mainly due to their solubility issues. In this context, this review article details various solubility enhancement techniques and their application mainly to address this poor solubility of various BCS class-II drugs.

UR - http://www.scopus.com/inward/record.url?scp=85029219402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029219402&partnerID=8YFLogxK

M3 - Review article

VL - 9

SP - 48

EP - 57

JO - Journal of Global Pharma Technology

JF - Journal of Global Pharma Technology

SN - 0975-8542

IS - 9

ER -