An update on solubility enhancement methods for BCS class -II drugs

Research output: Contribution to journalReview articlepeer-review


To attain the anticipated concentration of a drug in the systemic circulation in order to exhibit the pharmacologic response, solubility of the drug plays a critical role. Key research problems faced during formulation development of various drugs owe to their low aqueous solubility. About 40% of NCEs are unsuccessful in reaching their therapeutic range mainly due to their solubility issues. In this context, this review article details various solubility enhancement techniques and their application mainly to address this poor solubility of various BCS class-II drugs.

Original languageEnglish
Pages (from-to)48-57
Number of pages10
JournalJournal of Global Pharma Technology
Issue number9
Publication statusPublished - 01-09-2017

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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