Analgesic and anti-inflammatory activity of heartwood of Aquilaria agallocha in laboratory animals

Trupti Chitre, Pravin Bhutada, K. Nandakumar, Rahul Somani, Pankaj Miniyar, Yogita Mundhada, Sumati Gore, Kishor Jain

Research output: Contribution to journalArticle

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Abstract

Ethyl acetate extract of heartwood of Aquilaria agallocha (EAA) (Family: Thymelaceceae) was tested for analgesic and anti-inflammatory activities using established methods and models reported in literature. Inhibition of the Acetic Acid induced abdominal constriction was observed at the doses of EAA 50 (34.51 %), 100 (55.65 %) and 200 (65.29 %) mg/kg as compared to the control group. EAA reduced the pain in the early (neurogenic) phase at doses of 50 (26.68 %), 100 (39.49 %) and 200 (59.87 %) mg/kg and late (inflammatory) phase at doses of 50 (21.9 %), 100 (58.1 %) and 200 (80.2 %) mg/kg of formalin induced paw licking in mice. EAA 50 (34.3 %), 100 (44.44 %) and 200 (82.68 %) mg/kg showed significant increase in latency time for thermal stimulation in tail flick test. On the anti-inflammatory front, EAA 50 (51.38 %), 100 (55.09 %), 200 (56.25 %) showed a significant decrease in edema induced by carrageenan in the third hour of the assay (edema peak) when compared to the normal control. In cotton pellet granuloma formation, EAA 50 (43.46 %), 100 (68.24 %), 200 (77.18 %) showed a significant reduction in the weight of granuloma in rats. The potential to cause ulcers by EAA (50, 100 and 200 mg/kg, p,o.) was comparatively less than that of diclofenac. In conclusion, heartwood of Aquilaria agallocha has analgesic as well as anti-inflammatory activities.

Original languageEnglish
Pages (from-to)288-298
Number of pages11
JournalPharmacologyonline
Volume1
Publication statusPublished - 22-05-2007

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Thymelaeaceae
Laboratory Animals
Non-Steroidal Anti-Inflammatory Agents
Granuloma
Edema
Anti-Inflammatory Agents
Diclofenac
Carrageenan
Constriction
Acetic Acid
Formaldehyde
Ulcer
Analgesics
Tail
Weight Loss
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Chitre, T., Bhutada, P., Nandakumar, K., Somani, R., Miniyar, P., Mundhada, Y., ... Jain, K. (2007). Analgesic and anti-inflammatory activity of heartwood of Aquilaria agallocha in laboratory animals. Pharmacologyonline, 1, 288-298.
Chitre, Trupti ; Bhutada, Pravin ; Nandakumar, K. ; Somani, Rahul ; Miniyar, Pankaj ; Mundhada, Yogita ; Gore, Sumati ; Jain, Kishor. / Analgesic and anti-inflammatory activity of heartwood of Aquilaria agallocha in laboratory animals. In: Pharmacologyonline. 2007 ; Vol. 1. pp. 288-298.
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abstract = "Ethyl acetate extract of heartwood of Aquilaria agallocha (EAA) (Family: Thymelaceceae) was tested for analgesic and anti-inflammatory activities using established methods and models reported in literature. Inhibition of the Acetic Acid induced abdominal constriction was observed at the doses of EAA 50 (34.51 {\%}), 100 (55.65 {\%}) and 200 (65.29 {\%}) mg/kg as compared to the control group. EAA reduced the pain in the early (neurogenic) phase at doses of 50 (26.68 {\%}), 100 (39.49 {\%}) and 200 (59.87 {\%}) mg/kg and late (inflammatory) phase at doses of 50 (21.9 {\%}), 100 (58.1 {\%}) and 200 (80.2 {\%}) mg/kg of formalin induced paw licking in mice. EAA 50 (34.3 {\%}), 100 (44.44 {\%}) and 200 (82.68 {\%}) mg/kg showed significant increase in latency time for thermal stimulation in tail flick test. On the anti-inflammatory front, EAA 50 (51.38 {\%}), 100 (55.09 {\%}), 200 (56.25 {\%}) showed a significant decrease in edema induced by carrageenan in the third hour of the assay (edema peak) when compared to the normal control. In cotton pellet granuloma formation, EAA 50 (43.46 {\%}), 100 (68.24 {\%}), 200 (77.18 {\%}) showed a significant reduction in the weight of granuloma in rats. The potential to cause ulcers by EAA (50, 100 and 200 mg/kg, p,o.) was comparatively less than that of diclofenac. In conclusion, heartwood of Aquilaria agallocha has analgesic as well as anti-inflammatory activities.",
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Chitre, T, Bhutada, P, Nandakumar, K, Somani, R, Miniyar, P, Mundhada, Y, Gore, S & Jain, K 2007, 'Analgesic and anti-inflammatory activity of heartwood of Aquilaria agallocha in laboratory animals', Pharmacologyonline, vol. 1, pp. 288-298.

Analgesic and anti-inflammatory activity of heartwood of Aquilaria agallocha in laboratory animals. / Chitre, Trupti; Bhutada, Pravin; Nandakumar, K.; Somani, Rahul; Miniyar, Pankaj; Mundhada, Yogita; Gore, Sumati; Jain, Kishor.

In: Pharmacologyonline, Vol. 1, 22.05.2007, p. 288-298.

Research output: Contribution to journalArticle

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T1 - Analgesic and anti-inflammatory activity of heartwood of Aquilaria agallocha in laboratory animals

AU - Chitre, Trupti

AU - Bhutada, Pravin

AU - Nandakumar, K.

AU - Somani, Rahul

AU - Miniyar, Pankaj

AU - Mundhada, Yogita

AU - Gore, Sumati

AU - Jain, Kishor

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Y1 - 2007/5/22

N2 - Ethyl acetate extract of heartwood of Aquilaria agallocha (EAA) (Family: Thymelaceceae) was tested for analgesic and anti-inflammatory activities using established methods and models reported in literature. Inhibition of the Acetic Acid induced abdominal constriction was observed at the doses of EAA 50 (34.51 %), 100 (55.65 %) and 200 (65.29 %) mg/kg as compared to the control group. EAA reduced the pain in the early (neurogenic) phase at doses of 50 (26.68 %), 100 (39.49 %) and 200 (59.87 %) mg/kg and late (inflammatory) phase at doses of 50 (21.9 %), 100 (58.1 %) and 200 (80.2 %) mg/kg of formalin induced paw licking in mice. EAA 50 (34.3 %), 100 (44.44 %) and 200 (82.68 %) mg/kg showed significant increase in latency time for thermal stimulation in tail flick test. On the anti-inflammatory front, EAA 50 (51.38 %), 100 (55.09 %), 200 (56.25 %) showed a significant decrease in edema induced by carrageenan in the third hour of the assay (edema peak) when compared to the normal control. In cotton pellet granuloma formation, EAA 50 (43.46 %), 100 (68.24 %), 200 (77.18 %) showed a significant reduction in the weight of granuloma in rats. The potential to cause ulcers by EAA (50, 100 and 200 mg/kg, p,o.) was comparatively less than that of diclofenac. In conclusion, heartwood of Aquilaria agallocha has analgesic as well as anti-inflammatory activities.

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