Analgesic and antimicrobial studies of some 2,4-dichloro-5-fluorophenyl containing arylidenetriazolothiadiazines

Mari S. Karthikeyan, Bantwal S. Holla, Shalini Shenoy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

2,4-Dichloro-5-fluorophenyl containing 7-arylidenetriazolothiadiazines were obtained by the reaction of 4-amino-3-(2,4-dichloro-5-fluorophenyl)-5-mercapto- 1,2,4-triazole with 2,3-dibromo-1,3-diarylpropan-1-ones, and also by the reaction of 4-amino-3-(2,4-dichloro-5-fluorophenyl)-5-mercapto-1,2,4-triazole with α-bromopropenones in the presence of a base. The structure of the 7-arylidenetriazolothiadiazines was confirmed by an alternative synthesis. A plausible mechanism for the formation of 7-arylidenetriazolothiadiazines is proposed. All newly synthesized compounds were screened for their analgesic and antimicrobial activities. Compounds bearing 4-chlorophenyl or 3,4-methylenedioxyphenyl moieties at position 7 of the arylidenetriazolothiadiazines showed excellent analgesic activity. Arylidenetriazolothiadiazines carrying a phenyl, 4-chlorophenyl, 4-methylphenyl, 3,4-dimethoxyphenyl, and 2,4-dichlorophenyl moieties at position 7 showed excellent antibacterial and antifungal activities.

Original languageEnglish
Pages (from-to)707-716
Number of pages10
JournalMonatshefte fur Chemie
Volume139
Issue number6
DOIs
Publication statusPublished - 01-06-2008

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Analgesics
Bearings (structural)
1,2,4-triazole

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Karthikeyan, Mari S. ; Holla, Bantwal S. ; Shenoy, Shalini. / Analgesic and antimicrobial studies of some 2,4-dichloro-5-fluorophenyl containing arylidenetriazolothiadiazines. In: Monatshefte fur Chemie. 2008 ; Vol. 139, No. 6. pp. 707-716.
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Analgesic and antimicrobial studies of some 2,4-dichloro-5-fluorophenyl containing arylidenetriazolothiadiazines. / Karthikeyan, Mari S.; Holla, Bantwal S.; Shenoy, Shalini.

In: Monatshefte fur Chemie, Vol. 139, No. 6, 01.06.2008, p. 707-716.

Research output: Contribution to journalArticle

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