Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 70-78 |
| Number of pages | 9 |
| Journal | Research Journal of Pharmaceutical, Biological and Chemical Sciences |
| Volume | 4 |
| Issue number | 3 |
| Publication status | Published - 2013 |
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Analgesic modulation of tramadol, amitriptyline and gabapentin in male and female wistar rats. / Chogtu, B.; Bairy, K.L.; Satyam, S.M.; Pirasanthan, R.; Gupta, S.
In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 4, No. 3, 2013, p. 70-78.Research output: Contribution to journal › Article
TY - JOUR
T1 - Analgesic modulation of tramadol, amitriptyline and gabapentin in male and female wistar rats
AU - Chogtu, B.
AU - Bairy, K.L.
AU - Satyam, S.M.
AU - Pirasanthan, R.
AU - Gupta, S.
N1 - Cited By :1 Export Date: 28 November 2017 Correspondence Address: Chogtu, B.; Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka, India Chemicals/CAS: acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; amitriptyline, 50-48-6, 549-18-8; gabapentin, 60142-96-3; tramadol, 27203-92-5, 36282-47-0 Manufacturers: Cadila; Intas; Wockhardt References: Strazdins, L., Bammer, G., (2004) Soc Sci Med, 58, pp. 997-905; Claiborne, J., Nag, S., Mokha, S.S., (2006) The J Neurosci, 26 (50), pp. 13048-053; Meymandi, M.S., Sepehri, G., (2008) European J Anaesthesiol, 25 (2), pp. 129-134; Rose, M.A., Kam, P.C.A., (2002) Anaesthesia, 7, pp. 451-462; Mao, J., Chen, L.L., (2000) Anesth Analg, 91, pp. 680-687; Biçer, F., Eti, Z., Aricioglu, F., Konya, D., Gogus, Y., (2010) European J Anaesthesiol, 27 (47), p. 217; Abdi, S., Lee, D.H., Chung, J.M.O., (1998) Anesth Analg, 87, pp. 1360-1366; Aoki, M., Tsuji, M., Takeda, H., Harada, Y., Nohara, J., Matsumiya, J., Chiba, H., (2006) European J Pharmacol, 550, pp. 78-83; Kroin, J.S., Buvanendran, A., Nagalla, S.K.S., Tuman, K.J., (2003) Can J Anesth, 50, pp. 904-908; Vijay, P., Vijayvergia, R., (2010) Journal of Pharmaceutical Science and Technology, 2 (1), pp. 111-118; Bhutia, Y.D., Vijayaraghavan, R., Pathak, U., (2010) Indian J Pharmacol., 42 (1), pp. 17-20; Hurley, R.W., Adams, M.C.B., (2008) Anesth Analg, 107, pp. 309-317; Stoffela, E.C., Ulibarrib, C.M., Crafta, R.M., (2003) Pain, 103, pp. 285-202; Abdul Aziz, C.B., Nik Abdullah, N.M., (2005) The International Medical Journal, 4 (2), pp. 57-93; Duman, E.N., Kesim, M., Kadioglu, M., Ulku, C., Kalyoncu, N.I., Yaris, E., (2006) Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30, pp. 292-296; Korzeniewska-Rybicka, I., Płaznik, A., (1998) Pharmacol Biochem Behav, 59 (2), pp. 331-338; Goldlust, A., Su, T.Z., Wlty, D., Taylor, C.P., Oxander, D., (1995) Epilepsy Res, 22, pp. 1-11; Kilic, F.S., Sirmagul, B., Yildirim, E., Oner, S., Erol, K., (2012) Indian J Med Res, 135 (5), pp. 630-635; Chogtu, B., Bairy, K.L., Himabindu, P., Dhar, S., (2013) Int J Nutr Pharmacol Neurol Dis, 3, pp. 34-38
PY - 2013
Y1 - 2013
N2 - The central and peripheral analgesic response of tramadol, amitriptyline and gabapentin in male and female Wistar rats was measured using hot plate, tail-flick and acetic acid-induced writhing tests. In the first two methods withdrawal latency was measured at baseline and after administration of either tramadol (10 mg/kg, i.p.) ,amitriptyline (10 mg/kg, i.p.) or gabapentin (50 mg/kg, i.p.) at 15, 30, 60 and 120 minutes. In acetic acid induced writhing method, same drugs were given to both sex groups and then after 30 minutes, 2% acetic acid (2ml/kg, i.p.) was given and after 10 minutes number of writhes were counted.Tramadol showed significantly higher pain threshold in male rats than the female rats in response to hot plate test, tail-flick test and acetic acid induced writhing test. Amitriptyline treated male rats showed significantly higher pain threshold than the female rats in response to tail-flick method only. There was less number of writhing movements in gabapentin treated male rats as compared to female rats.The three drugs show different response in male and female rats. However, in some models there was no gender difference.
AB - The central and peripheral analgesic response of tramadol, amitriptyline and gabapentin in male and female Wistar rats was measured using hot plate, tail-flick and acetic acid-induced writhing tests. In the first two methods withdrawal latency was measured at baseline and after administration of either tramadol (10 mg/kg, i.p.) ,amitriptyline (10 mg/kg, i.p.) or gabapentin (50 mg/kg, i.p.) at 15, 30, 60 and 120 minutes. In acetic acid induced writhing method, same drugs were given to both sex groups and then after 30 minutes, 2% acetic acid (2ml/kg, i.p.) was given and after 10 minutes number of writhes were counted.Tramadol showed significantly higher pain threshold in male rats than the female rats in response to hot plate test, tail-flick test and acetic acid induced writhing test. Amitriptyline treated male rats showed significantly higher pain threshold than the female rats in response to tail-flick method only. There was less number of writhing movements in gabapentin treated male rats as compared to female rats.The three drugs show different response in male and female rats. However, in some models there was no gender difference.
M3 - Article
VL - 4
SP - 70
EP - 78
JO - Research Journal of Pharmaceutical, Biological and Chemical Sciences
JF - Research Journal of Pharmaceutical, Biological and Chemical Sciences
SN - 0975-8585
IS - 3
ER -