Analysis of prenatal and postnatal risk factors of retinopathy of prematurity in a tertiary care hospital in South India

Krishna A. Rao, Jayashree Purkayastha, Manali Hazarika, Raghuvamsi Chaitra, K. Mithun Adith

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Context: Recent advances in neonatology have influenced the incidence and severity of ROP in a dichotomous fashion. Aims: To determine the incidence of ROP and to analyse its risk factors. Settings and Design: Prospective clinical case series. Materials and Methods: 282 preterm infants with birthweight < 1500g and/or gestational age ≤ 32 weeks and also those with gestational age > 32 weeks, with birthweight between 1500-2000 g, who were at risk for ROP were selected. Weight gain proportion was measured as weight at 6 weeks minus birthweight divided by birthweight. Statistical Analysis: Univariate and multivariate logistic regression. Results: Incidence of any ROP was 21.6% while severe ROP was 6.7%. Prenatal factors like multiple gestation (P = 0.510) and antenatal steroids (P = 0.104) were not significantly associated with ROP. On multivariate analysis, postnatal factors like weight at birth < 1250 g (P = 0.01) and gestational age between 31-32 weeks (P = 0.02) were independent risk factors for any ROP, while intraventricular hemorrhage (P = 0.03) was the only independent risk factor for severe ROP. Mean birthweight of infants with severe ROP was 1056 μ 207 g (P = 0.004), which was significantly low. After logistic regression, the mean weight gain proportion at 6 weeks, of those neonates with severe ROP was 30%. Conclusions: Low birthweight and prematurity were the most important risk factors for developing any ROP, while intraventricular hemorrhage was the independent risk factor for developing severe ROP. The mean postnatal weight gain at 6 weeks was not statistically significant in neonates with severe ROP.

Original languageEnglish
Pages (from-to)640-644
Number of pages5
JournalIndian Journal of Ophthalmology
Volume61
Issue number11
DOIs
Publication statusPublished - 01-12-2013

Fingerprint

Retinopathy of Prematurity
Tertiary Healthcare
Tertiary Care Centers
India
Weight Gain
ROP
Incidence
Multivariate Analysis
Logistic Models
Newborn Infant
Hemorrhage
Neonatology
Birth Weight
Premature Infants
Gestational Age

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

@article{38995acb103f4635adbc9b14270b7744,
title = "Analysis of prenatal and postnatal risk factors of retinopathy of prematurity in a tertiary care hospital in South India",
abstract = "Context: Recent advances in neonatology have influenced the incidence and severity of ROP in a dichotomous fashion. Aims: To determine the incidence of ROP and to analyse its risk factors. Settings and Design: Prospective clinical case series. Materials and Methods: 282 preterm infants with birthweight < 1500g and/or gestational age ≤ 32 weeks and also those with gestational age > 32 weeks, with birthweight between 1500-2000 g, who were at risk for ROP were selected. Weight gain proportion was measured as weight at 6 weeks minus birthweight divided by birthweight. Statistical Analysis: Univariate and multivariate logistic regression. Results: Incidence of any ROP was 21.6{\%} while severe ROP was 6.7{\%}. Prenatal factors like multiple gestation (P = 0.510) and antenatal steroids (P = 0.104) were not significantly associated with ROP. On multivariate analysis, postnatal factors like weight at birth < 1250 g (P = 0.01) and gestational age between 31-32 weeks (P = 0.02) were independent risk factors for any ROP, while intraventricular hemorrhage (P = 0.03) was the only independent risk factor for severe ROP. Mean birthweight of infants with severe ROP was 1056 μ 207 g (P = 0.004), which was significantly low. After logistic regression, the mean weight gain proportion at 6 weeks, of those neonates with severe ROP was 30{\%}. Conclusions: Low birthweight and prematurity were the most important risk factors for developing any ROP, while intraventricular hemorrhage was the independent risk factor for developing severe ROP. The mean postnatal weight gain at 6 weeks was not statistically significant in neonates with severe ROP.",
author = "Rao, {Krishna A.} and Jayashree Purkayastha and Manali Hazarika and Raghuvamsi Chaitra and {Mithun Adith}, K.",
year = "2013",
month = "12",
day = "1",
doi = "10.4103/0301-4738.119347",
language = "English",
volume = "61",
pages = "640--644",
journal = "Indian Journal of Ophthalmology",
issn = "0301-4738",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "11",

}

Analysis of prenatal and postnatal risk factors of retinopathy of prematurity in a tertiary care hospital in South India. / Rao, Krishna A.; Purkayastha, Jayashree; Hazarika, Manali; Chaitra, Raghuvamsi; Mithun Adith, K.

In: Indian Journal of Ophthalmology, Vol. 61, No. 11, 01.12.2013, p. 640-644.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Analysis of prenatal and postnatal risk factors of retinopathy of prematurity in a tertiary care hospital in South India

AU - Rao, Krishna A.

AU - Purkayastha, Jayashree

AU - Hazarika, Manali

AU - Chaitra, Raghuvamsi

AU - Mithun Adith, K.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Context: Recent advances in neonatology have influenced the incidence and severity of ROP in a dichotomous fashion. Aims: To determine the incidence of ROP and to analyse its risk factors. Settings and Design: Prospective clinical case series. Materials and Methods: 282 preterm infants with birthweight < 1500g and/or gestational age ≤ 32 weeks and also those with gestational age > 32 weeks, with birthweight between 1500-2000 g, who were at risk for ROP were selected. Weight gain proportion was measured as weight at 6 weeks minus birthweight divided by birthweight. Statistical Analysis: Univariate and multivariate logistic regression. Results: Incidence of any ROP was 21.6% while severe ROP was 6.7%. Prenatal factors like multiple gestation (P = 0.510) and antenatal steroids (P = 0.104) were not significantly associated with ROP. On multivariate analysis, postnatal factors like weight at birth < 1250 g (P = 0.01) and gestational age between 31-32 weeks (P = 0.02) were independent risk factors for any ROP, while intraventricular hemorrhage (P = 0.03) was the only independent risk factor for severe ROP. Mean birthweight of infants with severe ROP was 1056 μ 207 g (P = 0.004), which was significantly low. After logistic regression, the mean weight gain proportion at 6 weeks, of those neonates with severe ROP was 30%. Conclusions: Low birthweight and prematurity were the most important risk factors for developing any ROP, while intraventricular hemorrhage was the independent risk factor for developing severe ROP. The mean postnatal weight gain at 6 weeks was not statistically significant in neonates with severe ROP.

AB - Context: Recent advances in neonatology have influenced the incidence and severity of ROP in a dichotomous fashion. Aims: To determine the incidence of ROP and to analyse its risk factors. Settings and Design: Prospective clinical case series. Materials and Methods: 282 preterm infants with birthweight < 1500g and/or gestational age ≤ 32 weeks and also those with gestational age > 32 weeks, with birthweight between 1500-2000 g, who were at risk for ROP were selected. Weight gain proportion was measured as weight at 6 weeks minus birthweight divided by birthweight. Statistical Analysis: Univariate and multivariate logistic regression. Results: Incidence of any ROP was 21.6% while severe ROP was 6.7%. Prenatal factors like multiple gestation (P = 0.510) and antenatal steroids (P = 0.104) were not significantly associated with ROP. On multivariate analysis, postnatal factors like weight at birth < 1250 g (P = 0.01) and gestational age between 31-32 weeks (P = 0.02) were independent risk factors for any ROP, while intraventricular hemorrhage (P = 0.03) was the only independent risk factor for severe ROP. Mean birthweight of infants with severe ROP was 1056 μ 207 g (P = 0.004), which was significantly low. After logistic regression, the mean weight gain proportion at 6 weeks, of those neonates with severe ROP was 30%. Conclusions: Low birthweight and prematurity were the most important risk factors for developing any ROP, while intraventricular hemorrhage was the independent risk factor for developing severe ROP. The mean postnatal weight gain at 6 weeks was not statistically significant in neonates with severe ROP.

UR - http://www.scopus.com/inward/record.url?scp=84893148588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893148588&partnerID=8YFLogxK

U2 - 10.4103/0301-4738.119347

DO - 10.4103/0301-4738.119347

M3 - Article

C2 - 24145565

AN - SCOPUS:84893148588

VL - 61

SP - 640

EP - 644

JO - Indian Journal of Ophthalmology

JF - Indian Journal of Ophthalmology

SN - 0301-4738

IS - 11

ER -