Analytical method development and validation for aspirin

S. Suresh Kumar, Latif D. Jamadar, Krishnamurthy Bhat, Prashant B. Musmade, S. G. Vasantharaju, N. Udupa

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A sensitive, specific, precise and cost effective High Performance Liquid Chromatographic method of analysis for aspirin in presence of its degradation products is developed and validated. The method employed Hypersil BDS C 18 (100 x 4.6 mm 5μ) column as stationary phase.The mobile phase consisted of sodium perchlorate buffer (pH 2.5): acetonitrile: isopropyl alcohol (85:14:1 % v/v). It is pumped through the chromatographic system at a flow rate of 1.5 ml min-1.The UV detector is operated at 275 nm. This system was found to give good resolution between aspirin and its degradation products. Method was validated as per ICH guidelines.

Original languageEnglish
Pages (from-to)389-399
Number of pages11
JournalInternational Journal of ChemTech Research
Volume2
Issue number1
Publication statusPublished - 01-2010

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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