Angiogenesis in cutaneous lesions of leprosy

Implications for treatment

Sulochana S. Bhandarkar, Cynthia Cohen, Maria Kuruvila, Thomas H. Rea, Jamie B. MacKelfresh, Delphine J. Lee, Robert L. Modlin, Jack L. Arbiser

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: To examine the potential role of angiogenesis in leprosy. Design: Immunohistochemical analysis of leprosy lesions. Setting: Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University. Patients: Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients. Main Outcome Measure: CD31 microvessel counts. Results: The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions. Conclusions: Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.

Original languageEnglish
Pages (from-to)1527-1529
Number of pages3
JournalArchives of Dermatology
Volume143
Issue number12
DOIs
Publication statusPublished - 01-12-2007

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Lepromatous Leprosy
Leprosy
Dermatology
Multibacillary Leprosy
Microvessels
Paucibacillary Leprosy
Venereology
Tuberculoid Leprosy
Therapeutics
Angiogenesis Inhibitors
Los Angeles
Bacterial Load
Outcome Assessment (Health Care)
Pathology
Skin

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Bhandarkar, S. S., Cohen, C., Kuruvila, M., Rea, T. H., MacKelfresh, J. B., Lee, D. J., ... Arbiser, J. L. (2007). Angiogenesis in cutaneous lesions of leprosy: Implications for treatment. Archives of Dermatology, 143(12), 1527-1529. https://doi.org/10.1001/archderm.143.12.1527
Bhandarkar, Sulochana S. ; Cohen, Cynthia ; Kuruvila, Maria ; Rea, Thomas H. ; MacKelfresh, Jamie B. ; Lee, Delphine J. ; Modlin, Robert L. ; Arbiser, Jack L. / Angiogenesis in cutaneous lesions of leprosy : Implications for treatment. In: Archives of Dermatology. 2007 ; Vol. 143, No. 12. pp. 1527-1529.
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Bhandarkar, SS, Cohen, C, Kuruvila, M, Rea, TH, MacKelfresh, JB, Lee, DJ, Modlin, RL & Arbiser, JL 2007, 'Angiogenesis in cutaneous lesions of leprosy: Implications for treatment', Archives of Dermatology, vol. 143, no. 12, pp. 1527-1529. https://doi.org/10.1001/archderm.143.12.1527

Angiogenesis in cutaneous lesions of leprosy : Implications for treatment. / Bhandarkar, Sulochana S.; Cohen, Cynthia; Kuruvila, Maria; Rea, Thomas H.; MacKelfresh, Jamie B.; Lee, Delphine J.; Modlin, Robert L.; Arbiser, Jack L.

In: Archives of Dermatology, Vol. 143, No. 12, 01.12.2007, p. 1527-1529.

Research output: Contribution to journalArticle

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AU - Cohen, Cynthia

AU - Kuruvila, Maria

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AU - MacKelfresh, Jamie B.

AU - Lee, Delphine J.

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AU - Arbiser, Jack L.

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