Angiogenesis in cutaneous lesions of leprosy: Implications for treatment

Sulochana S. Bhandarkar, Cynthia Cohen, Maria Kuruvila, Thomas H. Rea, Jamie B. MacKelfresh, Delphine J. Lee, Robert L. Modlin, Jack L. Arbiser

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Objective: To examine the potential role of angiogenesis in leprosy. Design: Immunohistochemical analysis of leprosy lesions. Setting: Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University. Patients: Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients. Main Outcome Measure: CD31 microvessel counts. Results: The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions. Conclusions: Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.

Original languageEnglish
Pages (from-to)1527-1529
Number of pages3
JournalArchives of Dermatology
Volume143
Issue number12
DOIs
Publication statusPublished - 01-12-2007

All Science Journal Classification (ASJC) codes

  • Dermatology

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