Angiogenesis in cutaneous lesions of leprosy: Implications for treatment

Sulochana S. Bhandarkar, Cynthia Cohen, Maria Kuruvila, Thomas H. Rea, Jamie B. MacKelfresh, Delphine J. Lee, Robert L. Modlin, Jack L. Arbiser

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10 Citations (Scopus)


Objective: To examine the potential role of angiogenesis in leprosy. Design: Immunohistochemical analysis of leprosy lesions. Setting: Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University. Patients: Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients. Main Outcome Measure: CD31 microvessel counts. Results: The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions. Conclusions: Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.

Original languageEnglish
Pages (from-to)1527-1529
Number of pages3
JournalArchives of Dermatology
Issue number12
Publication statusPublished - 01-12-2007

All Science Journal Classification (ASJC) codes

  • Dermatology

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    Bhandarkar, S. S., Cohen, C., Kuruvila, M., Rea, T. H., MacKelfresh, J. B., Lee, D. J., Modlin, R. L., & Arbiser, J. L. (2007). Angiogenesis in cutaneous lesions of leprosy: Implications for treatment. Archives of Dermatology, 143(12), 1527-1529.