Angiogenesis in cutaneous lesions of leprosy: Implications for treatment

Sulochana S. Bhandarkar, Cynthia Cohen, Maria Kuruvila, Thomas H. Rea, Jamie B. MacKelfresh, Delphine J. Lee, Robert L. Modlin, Jack L. Arbiser

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Abstract

Objective: To examine the potential role of angiogenesis in leprosy. Design: Immunohistochemical analysis of leprosy lesions. Setting: Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University. Patients: Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients. Main Outcome Measure: CD31 microvessel counts. Results: The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions. Conclusions: Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.

Original languageEnglish
Pages (from-to)1527-1529
Number of pages3
JournalArchives of Dermatology
Volume143
Issue number12
DOIs
Publication statusPublished - 01-12-2007

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All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Bhandarkar, S. S., Cohen, C., Kuruvila, M., Rea, T. H., MacKelfresh, J. B., Lee, D. J., ... Arbiser, J. L. (2007). Angiogenesis in cutaneous lesions of leprosy: Implications for treatment. Archives of Dermatology, 143(12), 1527-1529. https://doi.org/10.1001/archderm.143.12.1527