Anti-adipogenic activity of Capsicum annum (Solanaceae) in 3T3 L1

M. Arumugam, P. Vijayan, C. Raghu, G. Ashok, S. A. Dhanaraj, C. T. Kumarappan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Various extracts of Capsicum annum L were screened for their cytotoxicity and antiadipogenic activity in vitro. In cytotoxic studies all the extracts were screened against the 3T3 L1 cell line. Micro titre tetrazolium (MTT) and sulpho rhodamine B (SRB) assays against the 3T3 L1 cell line determined cytotoxicity. Methanol extract of fruit showed higher cytotoxicity with a lower CTC50 value of 167.46 μg/ml and the remaining extracts show CTC50 ranging from 180-282 μg/ml. In 3T3 L1 cells dexamethazone, 3- isobutyl-1-methyl xanthine (IBMX) and insulin, induced adipogenesis. All the four extracts (methanolic and water extracts of whole plant and fruit) were screened for their antiadipogenic activity in 3T3 L1 cell line; the methanolic fruit extract showed good antiadipogenic activity at 100 μg/ml.

Original languageEnglish
Article number28
JournalJournal of Complementary and Integrative Medicine
Volume5
Issue number1
Publication statusPublished - 12-11-2008

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Solanaceae
3T3-L1 Cells
Capsicum
Fruit
rhodamine B
Cell Line
Adipogenesis
Xanthine
Plant Extracts
Methanol
Insulin
Water

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

Cite this

Arumugam, M., Vijayan, P., Raghu, C., Ashok, G., Dhanaraj, S. A., & Kumarappan, C. T. (2008). Anti-adipogenic activity of Capsicum annum (Solanaceae) in 3T3 L1. Journal of Complementary and Integrative Medicine, 5(1), [28].
Arumugam, M. ; Vijayan, P. ; Raghu, C. ; Ashok, G. ; Dhanaraj, S. A. ; Kumarappan, C. T. / Anti-adipogenic activity of Capsicum annum (Solanaceae) in 3T3 L1. In: Journal of Complementary and Integrative Medicine. 2008 ; Vol. 5, No. 1.
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Arumugam, M, Vijayan, P, Raghu, C, Ashok, G, Dhanaraj, SA & Kumarappan, CT 2008, 'Anti-adipogenic activity of Capsicum annum (Solanaceae) in 3T3 L1', Journal of Complementary and Integrative Medicine, vol. 5, no. 1, 28.

Anti-adipogenic activity of Capsicum annum (Solanaceae) in 3T3 L1. / Arumugam, M.; Vijayan, P.; Raghu, C.; Ashok, G.; Dhanaraj, S. A.; Kumarappan, C. T.

In: Journal of Complementary and Integrative Medicine, Vol. 5, No. 1, 28, 12.11.2008.

Research output: Contribution to journalArticle

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Arumugam M, Vijayan P, Raghu C, Ashok G, Dhanaraj SA, Kumarappan CT. Anti-adipogenic activity of Capsicum annum (Solanaceae) in 3T3 L1. Journal of Complementary and Integrative Medicine. 2008 Nov 12;5(1). 28.