Anti-arthritic property of the plant Rubia cordifolia Lin

P. Jaijesh, K.K. Srinivasan, P. Bhagath Kumar, G. Sreejith, A.M. Ciraj

Research output: Contribution to journalArticle

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Abstract

Objective: To study the anti arthritic effect of ethanolic extract of the plant rubia cordifolia. Methods: Arthritis is induced in albino rats by injecting Freund's Complete Adjuvant and Bovine type II Collagen. Effectiveness of the plant extract is evaluated by comparing with that of a standard non-steroidal anti inflammatory drug Aspirin. Treatment is assessed by using various blood parameters and also by taking the change in paw volume. Results: Ethanolic extract of rubia cordifolia showed significant anti arthritic activity which was statistically similar to aspirin. The results suggest that the ethanolic extract of rubia cordifolia exhibits significant anti-arthritic potential.
Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalPharmacologyonline
Volume1
Publication statusPublished - 2008

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Rubia
Arthritis
Plant Extracts
Aspirin
Collagen Type II
Freund's Adjuvant
Anti-Inflammatory Agents
Pharmaceutical Preparations

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Jaijesh, P., Srinivasan, K. K., Bhagath Kumar, P., Sreejith, G., & Ciraj, A. M. (2008). Anti-arthritic property of the plant Rubia cordifolia Lin. Pharmacologyonline, 1, 107-113.
Jaijesh, P. ; Srinivasan, K.K. ; Bhagath Kumar, P. ; Sreejith, G. ; Ciraj, A.M. / Anti-arthritic property of the plant Rubia cordifolia Lin. In: Pharmacologyonline. 2008 ; Vol. 1. pp. 107-113.
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title = "Anti-arthritic property of the plant Rubia cordifolia Lin",
abstract = "Objective: To study the anti arthritic effect of ethanolic extract of the plant rubia cordifolia. Methods: Arthritis is induced in albino rats by injecting Freund's Complete Adjuvant and Bovine type II Collagen. Effectiveness of the plant extract is evaluated by comparing with that of a standard non-steroidal anti inflammatory drug Aspirin. Treatment is assessed by using various blood parameters and also by taking the change in paw volume. Results: Ethanolic extract of rubia cordifolia showed significant anti arthritic activity which was statistically similar to aspirin. The results suggest that the ethanolic extract of rubia cordifolia exhibits significant anti-arthritic potential.",
author = "P. Jaijesh and K.K. Srinivasan and {Bhagath Kumar}, P. and G. Sreejith and A.M. Ciraj",
note = "Cited By :7 Export Date: 10 November 2017 Correspondence Address: Jaijesh, P.; Department of Anatomy, Melaka Manipal Medical College, Manipal, Karnataka, India Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; C reactive protein, 9007-41-4; copper, 15158-11-9, 7440-50-8; hemoglobin, 9008-02-0 Tradenames: aspirin References: Miyazawa, M., Kawata, J., Identification of the key aroma compounds in dried roots of rubia cordifolia (2006) J. Oleo Sci, 55 (1), pp. 37-39; Newbould, B.B., Chemotherapy of arthritis induced in rats by Mycobacterial adjuvant (1963) Br J Pharmacol, 21, pp. 127-136; Mizushima, Y., Tsukada, W., Akimoto, T., A modification of rat adjuvant arthritis for testing antirheumatic drugs (1972) J Pharm Pharmacol, 24, pp. 781-785; Anthony, D.D., Haqqi, T.M., Collagen-induced arthritis in mice: An animal model to study the pathogenesis of rheumatoid arthritis (1999) Clin Exp Rheumatol, 17, pp. 240-244; Taneja, V., Taneja, N., Paisansinsup, T., CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: Implications for rheumatoid arthritis (2002) J Immunol, 168, pp. 5867-5875; Feldmann, M., Brennan, F.M., Maini, R.N., Role of cytokines in rheumatoid arthritis (1996) Annu Rev Immunol, 14, pp. 397-440; Begum, V.H., Sadique, J., Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats (1988) Indian J Exp Biol, 26, pp. 877-882; Allar, S., O'Driscoll, J., Laurie, A., Salmonella osteomyelitis in aplastic anaemia after antilymphocytic globulin and steroid treatment (1977) J Clin Pathol, 2, pp. 174-175; Mowat, G., Haematological abnormalities in rheumatoid arthritis (1971) Semin Arthritis Rheum, 1, pp. 195-199; Maria, M., Engeniusz, M., Miroslaw, K., Maria, K., Iwona, P., Adjuvant induced disease in rats, clinical findings and morphological and biochemical changes in the blood histological changes in internal organs (1983) Rheumatology, 2, pp. 231-245; McConkey, B., Crockson, R.A., Crockson, A.P., Nilkinson, A.R., The effect of some anti inflammatory drugs on the acute-phase proteins in rheumatoid arthritis (1973) Q J Med, 32, pp. 785-791; White, A.G., Scudder, P., Dormandy, T.L., Copper-an index of erosive activity? (1978) Rheumatology, 17, pp. 3-5; Suzuki, H., Matsumoto, T., Mikami, Y., Effects of nutritional factors on the formation of anthraquinones by rubia cordifolia plant cells in suspension culture (1984) Agricultural and Biological Chemistry, 48 (3), pp. 603-610; Chen, R.F., Shen, Y.C., Huang, H.S., Evaluation of the anti-inflammatory and cytotoxic effects of anthraquinones and anthracenes derivatives in human leucocytes (2004) Journal of Pharmacy and Pharmacology, 56 (7), pp. 915-919",
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Jaijesh, P, Srinivasan, KK, Bhagath Kumar, P, Sreejith, G & Ciraj, AM 2008, 'Anti-arthritic property of the plant Rubia cordifolia Lin', Pharmacologyonline, vol. 1, pp. 107-113.

Anti-arthritic property of the plant Rubia cordifolia Lin. / Jaijesh, P.; Srinivasan, K.K.; Bhagath Kumar, P.; Sreejith, G.; Ciraj, A.M.

In: Pharmacologyonline, Vol. 1, 2008, p. 107-113.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Jaijesh, P.

AU - Srinivasan, K.K.

AU - Bhagath Kumar, P.

AU - Sreejith, G.

AU - Ciraj, A.M.

N1 - Cited By :7 Export Date: 10 November 2017 Correspondence Address: Jaijesh, P.; Department of Anatomy, Melaka Manipal Medical College, Manipal, Karnataka, India Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; C reactive protein, 9007-41-4; copper, 15158-11-9, 7440-50-8; hemoglobin, 9008-02-0 Tradenames: aspirin References: Miyazawa, M., Kawata, J., Identification of the key aroma compounds in dried roots of rubia cordifolia (2006) J. Oleo Sci, 55 (1), pp. 37-39; Newbould, B.B., Chemotherapy of arthritis induced in rats by Mycobacterial adjuvant (1963) Br J Pharmacol, 21, pp. 127-136; Mizushima, Y., Tsukada, W., Akimoto, T., A modification of rat adjuvant arthritis for testing antirheumatic drugs (1972) J Pharm Pharmacol, 24, pp. 781-785; Anthony, D.D., Haqqi, T.M., Collagen-induced arthritis in mice: An animal model to study the pathogenesis of rheumatoid arthritis (1999) Clin Exp Rheumatol, 17, pp. 240-244; Taneja, V., Taneja, N., Paisansinsup, T., CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: Implications for rheumatoid arthritis (2002) J Immunol, 168, pp. 5867-5875; Feldmann, M., Brennan, F.M., Maini, R.N., Role of cytokines in rheumatoid arthritis (1996) Annu Rev Immunol, 14, pp. 397-440; Begum, V.H., Sadique, J., Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats (1988) Indian J Exp Biol, 26, pp. 877-882; Allar, S., O'Driscoll, J., Laurie, A., Salmonella osteomyelitis in aplastic anaemia after antilymphocytic globulin and steroid treatment (1977) J Clin Pathol, 2, pp. 174-175; Mowat, G., Haematological abnormalities in rheumatoid arthritis (1971) Semin Arthritis Rheum, 1, pp. 195-199; Maria, M., Engeniusz, M., Miroslaw, K., Maria, K., Iwona, P., Adjuvant induced disease in rats, clinical findings and morphological and biochemical changes in the blood histological changes in internal organs (1983) Rheumatology, 2, pp. 231-245; McConkey, B., Crockson, R.A., Crockson, A.P., Nilkinson, A.R., The effect of some anti inflammatory drugs on the acute-phase proteins in rheumatoid arthritis (1973) Q J Med, 32, pp. 785-791; White, A.G., Scudder, P., Dormandy, T.L., Copper-an index of erosive activity? (1978) Rheumatology, 17, pp. 3-5; Suzuki, H., Matsumoto, T., Mikami, Y., Effects of nutritional factors on the formation of anthraquinones by rubia cordifolia plant cells in suspension culture (1984) Agricultural and Biological Chemistry, 48 (3), pp. 603-610; Chen, R.F., Shen, Y.C., Huang, H.S., Evaluation of the anti-inflammatory and cytotoxic effects of anthraquinones and anthracenes derivatives in human leucocytes (2004) Journal of Pharmacy and Pharmacology, 56 (7), pp. 915-919

PY - 2008

Y1 - 2008

N2 - Objective: To study the anti arthritic effect of ethanolic extract of the plant rubia cordifolia. Methods: Arthritis is induced in albino rats by injecting Freund's Complete Adjuvant and Bovine type II Collagen. Effectiveness of the plant extract is evaluated by comparing with that of a standard non-steroidal anti inflammatory drug Aspirin. Treatment is assessed by using various blood parameters and also by taking the change in paw volume. Results: Ethanolic extract of rubia cordifolia showed significant anti arthritic activity which was statistically similar to aspirin. The results suggest that the ethanolic extract of rubia cordifolia exhibits significant anti-arthritic potential.

AB - Objective: To study the anti arthritic effect of ethanolic extract of the plant rubia cordifolia. Methods: Arthritis is induced in albino rats by injecting Freund's Complete Adjuvant and Bovine type II Collagen. Effectiveness of the plant extract is evaluated by comparing with that of a standard non-steroidal anti inflammatory drug Aspirin. Treatment is assessed by using various blood parameters and also by taking the change in paw volume. Results: Ethanolic extract of rubia cordifolia showed significant anti arthritic activity which was statistically similar to aspirin. The results suggest that the ethanolic extract of rubia cordifolia exhibits significant anti-arthritic potential.

M3 - Article

VL - 1

SP - 107

EP - 113

JO - Pharmacologyonline

JF - Pharmacologyonline

SN - 1827-8620

ER -