Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats

R. A.R. Naresh, G. K. Pillai, N. Udupa, G. Chandrashekar

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Synthetic analogues of liposomes prepared from non-ionic surfactants, known as niosomes, have been used as vesicular drug carriers. Diclofenac sodium has been entrapped in niosomes comprising Tween 85 and Tween 85- poloxamer F 108 mixture. Anti-inflammatory efficacy of these niosomes were compared with that of free diclofenac sodium in adjuvant induced arthritic rats. It was found that the niosomal diclofenac sodium formulations prepared by employing a 1:1 combination of Tween 85 and poloxamer F 108 elicits a better and consistent anti-inflammatory activity for more than 72 hours after administration of a single dose.

Original languageEnglish
Pages (from-to)46-48
Number of pages3
JournalIndian Journal of Pharmacology
Volume26
Issue number1
Publication statusPublished - 1994

Fingerprint

Diclofenac
Liposomes
Arthritis
Polysorbates
Anti-Inflammatory Agents
Poloxamer
Drug Carriers
Experimental Arthritis
Surface-Active Agents

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Naresh, R. A.R. ; Pillai, G. K. ; Udupa, N. ; Chandrashekar, G. / Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats. In: Indian Journal of Pharmacology. 1994 ; Vol. 26, No. 1. pp. 46-48.
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Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats. / Naresh, R. A.R.; Pillai, G. K.; Udupa, N.; Chandrashekar, G.

In: Indian Journal of Pharmacology, Vol. 26, No. 1, 1994, p. 46-48.

Research output: Contribution to journalArticle

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