Synthetic analogues of liposomes prepared from non-ionic surfactants, known as niosomes, have been used as vesicular drug carriers. Diclofenac sodium has been entrapped in niosomes comprising Tween 85 and Tween 85- poloxamer F 108 mixture. Anti-inflammatory efficacy of these niosomes were compared with that of free diclofenac sodium in adjuvant induced arthritic rats. It was found that the niosomal diclofenac sodium formulations prepared by employing a 1:1 combination of Tween 85 and poloxamer F 108 elicits a better and consistent anti-inflammatory activity for more than 72 hours after administration of a single dose.
|Number of pages||3|
|Journal||Indian Journal of Pharmacology|
|Publication status||Published - 1994|
All Science Journal Classification (ASJC) codes
- Pharmacology (medical)