Anti-inflammatory and Antinociceptive Activities of "Coccinia indica W. &A." Fruit Juice Powder in Animals

G.M.M. Rao, Ch.V. Rao, M. Sudhakara, M.M. Pandey, A.K.S. Rawat, A. Sirwaikar, A.B. Joshi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The fresh fruit juice powder of Coccinia indica W.&A., (Cucurbitaceae, CJP) was studied for the possible activities of antiinflammatory and antinociceptive to rationalize the folkloric use of the plant juice as rasayana. CJP at the doses of 50-200 mg/kg caused a significant (P<0.05 to P<0.001) inhibition of paw edema induced by λ carrageenin (1%) and histamine (10-3 g/ml, 0.1 ml) in rats. The effect was comparable to the standard cycloxygenase inhibitor brufen at 100 mg/kg and protective percentages were 63.41% and 65.78% respectively. Administration of CJP (50-200 mg/kg) exhibited a moderate increase of the pain threshold on analgesy-meter induced mechanical pain. However CJP significantly prevented the writhing induced by acetic acid in mice and the percentages of inhibitions were 16.98%-35.47%, which is equivalent to 36.67% produced by brufen. These data indicate that the fruit juice of Coccinia indica rationalizes the traditional system of medicine.
Original languageEnglish
Pages (from-to)20-23
Number of pages4
JournalNatural Product Sciences
Volume10
Issue number1
Publication statusPublished - 2004

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Fruit juices
Cucurbitaceae
Ibuprofen
Powders
Animals
Anti-Inflammatory Agents
Carrageenan
Acetic Acid
Histamine
Medicine
Rats
Pain Threshold
Traditional Medicine
Systems Analysis
Edema
Pain
Fruit and Vegetable Juices
Inhibition (Psychology)

Cite this

Rao, G. M. M., Rao, C. V., Sudhakara, M., Pandey, M. M., Rawat, A. K. S., Sirwaikar, A., & Joshi, A. B. (2004). Anti-inflammatory and Antinociceptive Activities of "Coccinia indica W. &A." Fruit Juice Powder in Animals. Natural Product Sciences, 10(1), 20-23.
Rao, G.M.M. ; Rao, Ch.V. ; Sudhakara, M. ; Pandey, M.M. ; Rawat, A.K.S. ; Sirwaikar, A. ; Joshi, A.B. / Anti-inflammatory and Antinociceptive Activities of "Coccinia indica W. &A." Fruit Juice Powder in Animals. In: Natural Product Sciences. 2004 ; Vol. 10, No. 1. pp. 20-23.
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abstract = "The fresh fruit juice powder of Coccinia indica W.&A., (Cucurbitaceae, CJP) was studied for the possible activities of antiinflammatory and antinociceptive to rationalize the folkloric use of the plant juice as rasayana. CJP at the doses of 50-200 mg/kg caused a significant (P<0.05 to P<0.001) inhibition of paw edema induced by λ carrageenin (1{\%}) and histamine (10-3 g/ml, 0.1 ml) in rats. The effect was comparable to the standard cycloxygenase inhibitor brufen at 100 mg/kg and protective percentages were 63.41{\%} and 65.78{\%} respectively. Administration of CJP (50-200 mg/kg) exhibited a moderate increase of the pain threshold on analgesy-meter induced mechanical pain. However CJP significantly prevented the writhing induced by acetic acid in mice and the percentages of inhibitions were 16.98{\%}-35.47{\%}, which is equivalent to 36.67{\%} produced by brufen. These data indicate that the fruit juice of Coccinia indica rationalizes the traditional system of medicine.",
author = "G.M.M. Rao and Ch.V. Rao and M. Sudhakara and M.M. Pandey and A.K.S. Rawat and A. Sirwaikar and A.B. Joshi",
note = "Cited By :7 Export Date: 10 November 2017 CODEN: NPSCF Correspondence Address: Rao, G.M.M.; Pharmacog./Ethnopharmacology Div., Natl. Botanical Research Institute, Lucknow, India; email: mmraos@rediffmail.com Chemicals/CAS: acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; histamine, 51-45-6, 56-92-8, 93443-21-1; ibuprofen, 15687-27-1 References: Alcaraz, M.J., Jimenez, M.J., Flavonoids as an antiinflammatory agents (1988) Fitoterapia, 59, pp. 25-38; Castro, J., Saseme, H., Sussman, H., Bullette, P., Diverse effect of SKF 52 and antioxidants on CCl4 induced changes in liver microsomal P-450 content and ethylmorphine metabolism (1968) Life. Sci., 7, pp. 129-136; Chawla, A.S., Singh, M., Murthy, M.S., Gupta, M.P., Singh, H., Anti-inflammatory action of ferulic acid and its esters in carrageenan induced rat paw oedema model (1987) Ind. J. Exp. Biol., 25, pp. 187-189; Della, L.A., Tubaro, A., Dri, P., Zilli, C., Del, N.P., The role of flavonoids in the antiinflammatory activity of chamomilla recutita (1968) Clin. Biol. Res., 213, pp. 481-486; Di Rosa, M., Biological properties of carrageenan (1972) J. Pharm. Pharmacol., 24, pp. 89-102; Kirtikar, K.R., Basu, B.D., (1933) Indian Medicinal Plants, 2, pp. 1151-1152. , Lalit Mohan Basu, Allhabad; Lino, C.S., Taveira, M.L., Viana, G.S.B., Matos, F.J.A., Analgesic and antiinflammatory activity of Justicia pectoralis Jacq and its main constituents: Coumarin & Umbelliferone (1997) Phytother. Res., 11, pp. 211-215; Miller, L.C., Tainter, M.L., Evaluation of ED50 and its error by means of logarithmic probit graph papers (1944) Proc. Soc. Exp. Biol. Med., 57, pp. 261-264; Nadkarni, A.K., (1954) Indian Materia Medica, 1, p. 300. , popular Book Depot, Bombay-1; Parmar, N.S., Ghosh, M.N., Antiinflammatory activity of Gossypin a bioflavonoid isolated from Hibiscus vitifolius Linn, Indian (1978) J. Pharmacol., 10, pp. 277-293; Pillai, N.R., Ghosh, D., Uma, R., Kumar, A., (1980) Bull. Med. Ethnobot. Res., 1, p. 234; Shaw, B.P., Gupta, S., (1981) Nagarjun, 25, p. 24; Spadaro, Evidence of correlation between mast-cell Histamine and Beta-Endorphin from Nil Pitutary in the Homoeostasis (1987) Pharmacol. Res. Commn., 19, pp. 131-136; Winter, C.A., Risley, E.A., Nuss, G.W., Carrageenin induced edema in hind paw of the rats as an assay for anti-inflammatory drugs (1962) Proc. Soc. Exp. Biol. Med., 111, pp. 544-547; Witkin, L.B., Huebner, C.F., Galdi, F., Okeefe, E., Spitaletta, P., Plummer, A.J., Pharmacognosy of 2 amino-indane hydrochloride (Su 8629): A potent non-narcotic analgesic (1961) J. Pharmacol. Exp. Therape., 133, pp. 400-408",
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Rao, GMM, Rao, CV, Sudhakara, M, Pandey, MM, Rawat, AKS, Sirwaikar, A & Joshi, AB 2004, 'Anti-inflammatory and Antinociceptive Activities of "Coccinia indica W. &A." Fruit Juice Powder in Animals', Natural Product Sciences, vol. 10, no. 1, pp. 20-23.

Anti-inflammatory and Antinociceptive Activities of "Coccinia indica W. &A." Fruit Juice Powder in Animals. / Rao, G.M.M.; Rao, Ch.V.; Sudhakara, M.; Pandey, M.M.; Rawat, A.K.S.; Sirwaikar, A.; Joshi, A.B.

In: Natural Product Sciences, Vol. 10, No. 1, 2004, p. 20-23.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anti-inflammatory and Antinociceptive Activities of "Coccinia indica W. &A." Fruit Juice Powder in Animals

AU - Rao, G.M.M.

AU - Rao, Ch.V.

AU - Sudhakara, M.

AU - Pandey, M.M.

AU - Rawat, A.K.S.

AU - Sirwaikar, A.

AU - Joshi, A.B.

N1 - Cited By :7 Export Date: 10 November 2017 CODEN: NPSCF Correspondence Address: Rao, G.M.M.; Pharmacog./Ethnopharmacology Div., Natl. Botanical Research Institute, Lucknow, India; email: mmraos@rediffmail.com Chemicals/CAS: acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; histamine, 51-45-6, 56-92-8, 93443-21-1; ibuprofen, 15687-27-1 References: Alcaraz, M.J., Jimenez, M.J., Flavonoids as an antiinflammatory agents (1988) Fitoterapia, 59, pp. 25-38; Castro, J., Saseme, H., Sussman, H., Bullette, P., Diverse effect of SKF 52 and antioxidants on CCl4 induced changes in liver microsomal P-450 content and ethylmorphine metabolism (1968) Life. Sci., 7, pp. 129-136; Chawla, A.S., Singh, M., Murthy, M.S., Gupta, M.P., Singh, H., Anti-inflammatory action of ferulic acid and its esters in carrageenan induced rat paw oedema model (1987) Ind. J. Exp. Biol., 25, pp. 187-189; Della, L.A., Tubaro, A., Dri, P., Zilli, C., Del, N.P., The role of flavonoids in the antiinflammatory activity of chamomilla recutita (1968) Clin. Biol. Res., 213, pp. 481-486; Di Rosa, M., Biological properties of carrageenan (1972) J. Pharm. Pharmacol., 24, pp. 89-102; Kirtikar, K.R., Basu, B.D., (1933) Indian Medicinal Plants, 2, pp. 1151-1152. , Lalit Mohan Basu, Allhabad; Lino, C.S., Taveira, M.L., Viana, G.S.B., Matos, F.J.A., Analgesic and antiinflammatory activity of Justicia pectoralis Jacq and its main constituents: Coumarin & Umbelliferone (1997) Phytother. Res., 11, pp. 211-215; Miller, L.C., Tainter, M.L., Evaluation of ED50 and its error by means of logarithmic probit graph papers (1944) Proc. Soc. Exp. Biol. Med., 57, pp. 261-264; Nadkarni, A.K., (1954) Indian Materia Medica, 1, p. 300. , popular Book Depot, Bombay-1; Parmar, N.S., Ghosh, M.N., Antiinflammatory activity of Gossypin a bioflavonoid isolated from Hibiscus vitifolius Linn, Indian (1978) J. Pharmacol., 10, pp. 277-293; Pillai, N.R., Ghosh, D., Uma, R., Kumar, A., (1980) Bull. Med. Ethnobot. Res., 1, p. 234; Shaw, B.P., Gupta, S., (1981) Nagarjun, 25, p. 24; Spadaro, Evidence of correlation between mast-cell Histamine and Beta-Endorphin from Nil Pitutary in the Homoeostasis (1987) Pharmacol. Res. Commn., 19, pp. 131-136; Winter, C.A., Risley, E.A., Nuss, G.W., Carrageenin induced edema in hind paw of the rats as an assay for anti-inflammatory drugs (1962) Proc. Soc. Exp. Biol. Med., 111, pp. 544-547; Witkin, L.B., Huebner, C.F., Galdi, F., Okeefe, E., Spitaletta, P., Plummer, A.J., Pharmacognosy of 2 amino-indane hydrochloride (Su 8629): A potent non-narcotic analgesic (1961) J. Pharmacol. Exp. Therape., 133, pp. 400-408

PY - 2004

Y1 - 2004

N2 - The fresh fruit juice powder of Coccinia indica W.&A., (Cucurbitaceae, CJP) was studied for the possible activities of antiinflammatory and antinociceptive to rationalize the folkloric use of the plant juice as rasayana. CJP at the doses of 50-200 mg/kg caused a significant (P<0.05 to P<0.001) inhibition of paw edema induced by λ carrageenin (1%) and histamine (10-3 g/ml, 0.1 ml) in rats. The effect was comparable to the standard cycloxygenase inhibitor brufen at 100 mg/kg and protective percentages were 63.41% and 65.78% respectively. Administration of CJP (50-200 mg/kg) exhibited a moderate increase of the pain threshold on analgesy-meter induced mechanical pain. However CJP significantly prevented the writhing induced by acetic acid in mice and the percentages of inhibitions were 16.98%-35.47%, which is equivalent to 36.67% produced by brufen. These data indicate that the fruit juice of Coccinia indica rationalizes the traditional system of medicine.

AB - The fresh fruit juice powder of Coccinia indica W.&A., (Cucurbitaceae, CJP) was studied for the possible activities of antiinflammatory and antinociceptive to rationalize the folkloric use of the plant juice as rasayana. CJP at the doses of 50-200 mg/kg caused a significant (P<0.05 to P<0.001) inhibition of paw edema induced by λ carrageenin (1%) and histamine (10-3 g/ml, 0.1 ml) in rats. The effect was comparable to the standard cycloxygenase inhibitor brufen at 100 mg/kg and protective percentages were 63.41% and 65.78% respectively. Administration of CJP (50-200 mg/kg) exhibited a moderate increase of the pain threshold on analgesy-meter induced mechanical pain. However CJP significantly prevented the writhing induced by acetic acid in mice and the percentages of inhibitions were 16.98%-35.47%, which is equivalent to 36.67% produced by brufen. These data indicate that the fruit juice of Coccinia indica rationalizes the traditional system of medicine.

M3 - Article

VL - 10

SP - 20

EP - 23

JO - Natural Product Sciences

JF - Natural Product Sciences

SN - 1226-3907

IS - 1

ER -

Rao GMM, Rao CV, Sudhakara M, Pandey MM, Rawat AKS, Sirwaikar A et al. Anti-inflammatory and Antinociceptive Activities of "Coccinia indica W. &A." Fruit Juice Powder in Animals. Natural Product Sciences. 2004;10(1):20-23.