Anti-inflammatory, antipruritic and mast cell stabilizing activity of Aristolochia indica

Jessy Elizabeth Mathew, Srinivasan Keloth Kaitheri, Seekarajapuram Dinakaranvachala, Magi Jose

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5 Citations (Scopus)

Abstract

Objective(s): Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their antiinflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods: Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound 48/80 and sheep serum induced mast cell degranulation methods. Results: The ethanol extract (300 mg/kg) and petroleum ether extract (100 mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (69%) by compound 48/80 model. In sheep serum model the ethanol extracts (150 and 300 mg/kg) and petroleum ether extract (100 mg/kg) showed good mast cell stabilizing activity (66-67%). Ethanol extract at 150 mg/kg showed 70% reduction of rat paw oedema and also significantly reduced the scratching response. Conclusion: Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity.

Original languageEnglish
Pages (from-to)422-427
Number of pages6
JournalIranian Journal of Basic Medical Sciences
Volume14
Issue number5
Publication statusPublished - 01-09-2011

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Immunology and Microbiology(all)
  • Drug Discovery
  • Clinical Biochemistry

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