Anti-inflammatory, antipruritic and mast cell stabilizing activity of Aristolochia indica

Jessy Elizabeth Mathew, Srinivasan Keloth Kaitheri, Seekarajapuram Dinakaranvachala, Magi Jose

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective(s): Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their antiinflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods: Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound 48/80 and sheep serum induced mast cell degranulation methods. Results: The ethanol extract (300 mg/kg) and petroleum ether extract (100 mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (69%) by compound 48/80 model. In sheep serum model the ethanol extracts (150 and 300 mg/kg) and petroleum ether extract (100 mg/kg) showed good mast cell stabilizing activity (66-67%). Ethanol extract at 150 mg/kg showed 70% reduction of rat paw oedema and also significantly reduced the scratching response. Conclusion: Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity.

Original languageEnglish
Pages (from-to)422-427
Number of pages6
JournalIranian Journal of Basic Medical Sciences
Volume14
Issue number5
Publication statusPublished - 01-09-2011

Fingerprint

Antipruritics
Aristolochia
p-Methoxy-N-methylphenethylamine
Mast Cells
Anti-Inflammatory Agents
Ethanol
Rats
Ketotifen
Cell Degranulation
Medicine
Edema
Sheep
Traditional Medicine
Serum
Pharmaceutical Preparations
naphtha
Incidence

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Immunology and Microbiology(all)
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Mathew, Jessy Elizabeth ; Kaitheri, Srinivasan Keloth ; Dinakaranvachala, Seekarajapuram ; Jose, Magi. / Anti-inflammatory, antipruritic and mast cell stabilizing activity of Aristolochia indica. In: Iranian Journal of Basic Medical Sciences. 2011 ; Vol. 14, No. 5. pp. 422-427.
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abstract = "Objective(s): Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their antiinflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods: Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound 48/80 and sheep serum induced mast cell degranulation methods. Results: The ethanol extract (300 mg/kg) and petroleum ether extract (100 mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (69{\%}) by compound 48/80 model. In sheep serum model the ethanol extracts (150 and 300 mg/kg) and petroleum ether extract (100 mg/kg) showed good mast cell stabilizing activity (66-67{\%}). Ethanol extract at 150 mg/kg showed 70{\%} reduction of rat paw oedema and also significantly reduced the scratching response. Conclusion: Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity.",
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Anti-inflammatory, antipruritic and mast cell stabilizing activity of Aristolochia indica. / Mathew, Jessy Elizabeth; Kaitheri, Srinivasan Keloth; Dinakaranvachala, Seekarajapuram; Jose, Magi.

In: Iranian Journal of Basic Medical Sciences, Vol. 14, No. 5, 01.09.2011, p. 422-427.

Research output: Contribution to journalArticle

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