Anti-inflammatory effect of the methanol extract from Anthocephalus cadamba stem bark in animal models

Kodangala Subraya Chandrashekar, Borthakur Abinash, Kodangala Subraya Prasanna

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Anthocephalus cadamba (Rebox)Miq. (Rubiaceae) is widely distributed throughout the greater part of India, especially at low levels in wet place. Traditionally the bark is used as tonic, febrifuge and to reduce the pain and inflammation. The anti-inflammatory effect of methanol extract obtained from Anthocephalus cadamba aerial parts, MEAC, were investigated in this study. Design and methods: The effects of MEAC on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin) induced paw edema and cotton pallet-induced granuloma, respectively. The anti-edema effect of MEAC was compared with 10 mg/kg of indomethacin orally. Results: The results suggested that MEAC possess potent anti-inflammatory activity. The acute inflammatory model showed that all the doses of MEAC effectively suppressed the edema produced by histamine, so it may be suggested that its anti-inflammatory activity is possibly backed by its antihistaminic activity. In chronic inflammatory model the effect may be due to the cellular migration to injured sites and accumulation of collagen and mucopolysaccharide. Conclusions: On the basis of these findings, it may be inferred that Anthocephalus cadamba is an anti-inflammatory agent and the results are in agreement with its traditional use.

Original languageEnglish
Pages (from-to)30-32
Number of pages3
JournalInternational Journal of Plant Biology
Volume1
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Neolamarckia cadamba
anti-inflammatory activity
edema
bark
methanol
animal models
histamine
stems
extracts
inflammation
antihistamines
anti-inflammatory agents
pallets
indomethacin
carrageenan
glycosaminoglycans
Rubiaceae
granuloma
dextran
cell movement

All Science Journal Classification (ASJC) codes

  • Plant Science

Cite this

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abstract = "Anthocephalus cadamba (Rebox)Miq. (Rubiaceae) is widely distributed throughout the greater part of India, especially at low levels in wet place. Traditionally the bark is used as tonic, febrifuge and to reduce the pain and inflammation. The anti-inflammatory effect of methanol extract obtained from Anthocephalus cadamba aerial parts, MEAC, were investigated in this study. Design and methods: The effects of MEAC on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin) induced paw edema and cotton pallet-induced granuloma, respectively. The anti-edema effect of MEAC was compared with 10 mg/kg of indomethacin orally. Results: The results suggested that MEAC possess potent anti-inflammatory activity. The acute inflammatory model showed that all the doses of MEAC effectively suppressed the edema produced by histamine, so it may be suggested that its anti-inflammatory activity is possibly backed by its antihistaminic activity. In chronic inflammatory model the effect may be due to the cellular migration to injured sites and accumulation of collagen and mucopolysaccharide. Conclusions: On the basis of these findings, it may be inferred that Anthocephalus cadamba is an anti-inflammatory agent and the results are in agreement with its traditional use.",
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Anti-inflammatory effect of the methanol extract from Anthocephalus cadamba stem bark in animal models. / Chandrashekar, Kodangala Subraya; Abinash, Borthakur; Prasanna, Kodangala Subraya.

In: International Journal of Plant Biology, Vol. 1, No. 1, 2010, p. 30-32.

Research output: Contribution to journalArticle

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