Anti-microbial studies on novel 1,3-oxazolidine analogs

D. Vachala, J.E. Mathew, P. Panneerselvam, Sivagurunathan Nagarethinam

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Abstract

In present study several substituted 1, 3-oxazolidines were synthesized by condensation of reduced Schiff base of phenylglycinol with different aldehydes. All the synthesized compounds showed good to moderate antimicrobial activity. The antimicrobial activites were performed by disc diffusion method and minimum inhibitory concentration determination by serial agar dilution method. Thus among the ten compounds, 3-[3-2-furyl methyl)-4-phenyl- 1,3-Oxazolidin-2-yl]-1H-indole (4a), 2-(2-furyl)-3-(2-furyl methyl)-4-phenyl-1,3-Oxazolidine (4b) and 4-[3-(2-furylmethyl)-4-phenyl-1,3- oxazolidin-2-yl]-2-methoxy phenol (4h) were found to have a moderate to significant antimicrobial activity against all the strains used. Compound 2-(4-chlorophenyl)-3-(2- furylmethyl)-4-phenyl-1, 3-oxazolidine (4j) showed very good antifungal activity than- the other compounds tested. Further more, compounds containing -Cl-, -OCH3, -OH groups as substituents were found to be potent antimicrobial agents. Moreover the heteroaromatic substitutions also showed very good antimicrobial activities.
Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalPharmacologyonline
Volume2
Publication statusPublished - 2008

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Vachala, D., Mathew, J. E., Panneerselvam, P., & Nagarethinam, S. (2008). Anti-microbial studies on novel 1,3-oxazolidine analogs. Pharmacologyonline, 2, 192-197.