Anti-neoplastic activity of Anisochilus cornosus (L.f) wall on HeLa cell line

Jay Kumar Bhagath, Richard Lobo, Mamatha Ballal, Picheswara Rao Polu

Research output: Contribution to journalArticle

Abstract

Anisochilus carnosus (L.f.) wall is an annual herb belonging to the family Lamiaceae which grows on rocks. It is used traditionally for the treatment of gastric ulcers, skin infections, cough, cold, digestion and eczema. Plant was collected and extracted with petroleum ether, ethanol and water separately and all the three obtained extracts were screened for in vitro anticancer activity against human cervical carcinoma cell lines (HeLa) by using MTT and SRB assays. Cytotoxic potential showed by Petroleum ether and ethanolic extracts with an IC50 of 5.88μg/ml and 78.73μg/ml respectively when compared with Doxorubicin with IC50 of 1.86μg/ml in MTT assay. and IC50 of 17.93 μg/ml and 87.24 μg/ml respectively by SRB assay. Even though the cytotoxic activity shown by both petroleum ether and ethanolic extracts the possible mechanism for its cytotoxicity is not clear. Hence mechanistic evaluation of both plant extracts is needed in future research, so that we could come out with potent and selective anticancer agents derived from plant source.

Original languageEnglish
Pages (from-to)186-190
Number of pages5
JournalDer Pharmacia Lettre
Volume8
Issue number4
Publication statusPublished - 2016

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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