@article{40c8750d0e9747e597f2fb42adff8516,
title = "Anti-snake venom activity of different extracts of Pouzolzia indica against Russel viper venom",
abstract = "Snakebite is an important cause of morbidity and mortality and is one of the major health problems in India. Russell's viper or daboia (Viper russelli) appears to be the commonest cause of fatal snakebite in Southern India, Pakistan, Bangladesh, Sri Lanka, Burma and Thailand. Intravenous administration of antibothropic antivenom neutralizes the systemic actions, but it is of little effect on the reversal of local symptoms and often induces adverse reactions, a context that drives the search for complementary treatments for snakebite accidents. Vegetable extracts with a range of antiophidian activities constitute an excellent alternative. In this study, we investigated the anti-venom effects of different extracts of Pouzolzia indica. The alcoholic and aqueous extracts of P. indica showed potent snake venom neutralizing capacity against Russell viper venom.",
author = "A. Ahmed and K. Rajendaran and D. Jaiswal and H.P. Singh and A. Mishra and D. Chandra and I.K. Yadav and D.A. Jain",
note = "Cited By :12 Export Date: 10 November 2017 Correspondence Address: Ahmed, A.; Department of Pharmacognosy, MCOPS, Manipal-576104, India; email: neel_pharma@rediffmail.com Chemicals/CAS: acetone, 67-64-1; alcohol, 64-17-5; benzene, 71-43-2; petroleum, 8002-05-9; phospholipase, 9013-93-8 References: Bhardwaj A., Sokhey J., Snakebites in the hills of North India. Nat. Med. J. Ind., 1998, 11, 264-265; Warrel, D.A., (1995) Clinical toxicology of snakebites in Asia, pp. 493-594. , CRC press, Boca Raton. FL; De Silva A., Ranasinghe L., Epidemiology of snakebite in Sri Lanka: A review. Ceyl. Med. J., 1983, 28, 144-154; Ariaratnam, C.A., Sjostrom, L., Raziek, Z., An open randomized comparative trial of two antivenoms for the treatment of envenoming by Sri lankan russell's viper (Daboia russelii russelii) (2001) Trans Royal Soc Trop Med Hyg, 95, pp. 74-80; Singh, A., Biswal, N., Nalini, P., Acute pulmonary edema as a complication of anti-snake venom therapy, Ind (2001) J. Paed, 68, pp. 81-82; Otero, R., Gutierrez, J.M., Nunez, V., A randomized double blind clinical trial of two antivenoms in-patients bitten by bothrops atrox in Colombia (1996) Trans Royal Soc Trop Med & Hyg, 90, pp. 696-700; Heard, K., O'malley, G.F., Dart, R.C., Antivenom therapy in the americas (1999) Drugs, 58, pp. 5-15; Kokate, C.K., (1991) Practical pharmacognosy, pp. 107-121. , 3rdEdn, Vallabh Prakashan; Kokate, C.K., Purohit, A.P., Gokhale, S.B., Text of Pharmacognosy, Nirali Prakashan, 9th (1965) Edn, pp. 90-93; Harborne, J.B., (1998) Phytochemical Methods, pp. 123-175. , 3nd edn. Published by Chapman and Hill, London; Shirwaikar, A., Rajendran, K., Bodla, R., Kumar, C.D., Neutralization potential of Viper russelli russelli (Russell's viper) venom by ethanol leaf extract of Acalypha indica (2004) J .Ethnopharmacol, 94 (2-3), pp. 267-273; Meier, J., White, J., (1995) Handbook of clinical toxicology and animal venoms and poisons, pp. 240-357. , CRC Press, Boca Raton, FL; Theakston, R.D.G., Warrell, Reid, H.A., Development of simple standard assay procedures for the characterization of snake venom (1983) Bulletin of the World Health Organization, 61 (6), pp. 949-956; Kondo, H., Studies on the quantitative method for determination of haemorrhagic activity of Habu snake venom (1960) Jap. J. Med. Sci. Bio, 13, pp. 43-51; Kannappa Reddy, M., Viswanathan, S., Thirugnanasambantham, P., Kameshwaran, L., Effect of Leucus aspera on snake venom poisoning in mice and its possible mechanism of action (1993) Fitoterpia, 64, pp. 442-446; Hiroshi, O., Nobuko, O., Kunio, V., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction (1979) Analytical Biochemistry, 5, p. 351; Warrell, D.A., Snake venoms in Science and Clinical Medicine, 1. Russell's viper: Biology, Venom and Treatment of bites (1989) Trans. Royal Soc. Trop. Med. Hyg, 83, pp. 732-740; Slater, Russell's viper venom proteins: Molecular probes for neurotransmitter receptors: a review (1988) Comp. Biochem. Physio, 91, pp. 51-60; Alam, M.I., Gomes, A., Viper venom induced inflammation and inhibition of free radical formation by pure compound (2 - hydroxy - 4 - methoxy benzoic acid) isolate and purified from Anantmul (Hemidesmus indicus R. Br.) root extract (1998) Toxicon, 36, pp. 207-215",
year = "2010",
language = "English",
volume = "2",
pages = "744--751",
journal = "International Journal of ChemTech Research",
issn = "0974-4290",
publisher = "Sphinx Knowledge House",
number = "1",
}