Anti-urolithiatic activity of heart wood extract of cedrus deodara in Rats

C. Ramesh, Nandakumar Krishnadas, Rajesh Radhakrishnan, Srinath Rangappa, Gollapalle Lakshminarayana Shastry Viswanatha, D. Rajesh, Murugananthan Gopal, Sahil Talwar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h before sodium oxalate (NaOx) administration for 10 days. In NaOx treated rats, crystal was observed in urine under light microscope and elevation of serum parameters indicated the development of nephrolithiasis in the control group. Concomitant administration of PECD for 10 days along with NaOx prevented elevated serum biochemical levels due to the elimination of these in urine. Histology of the kidneys also indicated that PECD treatment had protected against NaOx induced nephroliathiasis. These results obtained, confirmed the beneficiary effect of Cedrus deodara in urolithiasis.

Original languageEnglish
Article number11
JournalJournal of Complementary and Integrative Medicine
Volume7
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Cedrus
Oxalic Acid
Urolithiasis
Urine
Nephrolithiasis
Serum
Diuretics
Histology
Kidney
Light
Control Groups
Therapeutics

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

Cite this

Ramesh, C. ; Krishnadas, Nandakumar ; Radhakrishnan, Rajesh ; Rangappa, Srinath ; Viswanatha, Gollapalle Lakshminarayana Shastry ; Rajesh, D. ; Gopal, Murugananthan ; Talwar, Sahil. / Anti-urolithiatic activity of heart wood extract of cedrus deodara in Rats. In: Journal of Complementary and Integrative Medicine. 2010 ; Vol. 7, No. 1.
@article{bb7d4fb083b646e09514e9f39f62d46e,
title = "Anti-urolithiatic activity of heart wood extract of cedrus deodara in Rats",
abstract = "The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h before sodium oxalate (NaOx) administration for 10 days. In NaOx treated rats, crystal was observed in urine under light microscope and elevation of serum parameters indicated the development of nephrolithiasis in the control group. Concomitant administration of PECD for 10 days along with NaOx prevented elevated serum biochemical levels due to the elimination of these in urine. Histology of the kidneys also indicated that PECD treatment had protected against NaOx induced nephroliathiasis. These results obtained, confirmed the beneficiary effect of Cedrus deodara in urolithiasis.",
author = "C. Ramesh and Nandakumar Krishnadas and Rajesh Radhakrishnan and Srinath Rangappa and Viswanatha, {Gollapalle Lakshminarayana Shastry} and D. Rajesh and Murugananthan Gopal and Sahil Talwar",
year = "2010",
doi = "10.2202/1553-3840.1311",
language = "English",
volume = "7",
journal = "Journal of Complementary and Integrative Medicine",
issn = "1553-3840",
publisher = "Berkeley Electronic Press",
number = "1",

}

Anti-urolithiatic activity of heart wood extract of cedrus deodara in Rats. / Ramesh, C.; Krishnadas, Nandakumar; Radhakrishnan, Rajesh; Rangappa, Srinath; Viswanatha, Gollapalle Lakshminarayana Shastry; Rajesh, D.; Gopal, Murugananthan; Talwar, Sahil.

In: Journal of Complementary and Integrative Medicine, Vol. 7, No. 1, 11, 2010.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anti-urolithiatic activity of heart wood extract of cedrus deodara in Rats

AU - Ramesh, C.

AU - Krishnadas, Nandakumar

AU - Radhakrishnan, Rajesh

AU - Rangappa, Srinath

AU - Viswanatha, Gollapalle Lakshminarayana Shastry

AU - Rajesh, D.

AU - Gopal, Murugananthan

AU - Talwar, Sahil

PY - 2010

Y1 - 2010

N2 - The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h before sodium oxalate (NaOx) administration for 10 days. In NaOx treated rats, crystal was observed in urine under light microscope and elevation of serum parameters indicated the development of nephrolithiasis in the control group. Concomitant administration of PECD for 10 days along with NaOx prevented elevated serum biochemical levels due to the elimination of these in urine. Histology of the kidneys also indicated that PECD treatment had protected against NaOx induced nephroliathiasis. These results obtained, confirmed the beneficiary effect of Cedrus deodara in urolithiasis.

AB - The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h before sodium oxalate (NaOx) administration for 10 days. In NaOx treated rats, crystal was observed in urine under light microscope and elevation of serum parameters indicated the development of nephrolithiasis in the control group. Concomitant administration of PECD for 10 days along with NaOx prevented elevated serum biochemical levels due to the elimination of these in urine. Histology of the kidneys also indicated that PECD treatment had protected against NaOx induced nephroliathiasis. These results obtained, confirmed the beneficiary effect of Cedrus deodara in urolithiasis.

UR - http://www.scopus.com/inward/record.url?scp=77952060045&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952060045&partnerID=8YFLogxK

U2 - 10.2202/1553-3840.1311

DO - 10.2202/1553-3840.1311

M3 - Article

VL - 7

JO - Journal of Complementary and Integrative Medicine

JF - Journal of Complementary and Integrative Medicine

SN - 1553-3840

IS - 1

M1 - 11

ER -