Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus LINN

S.K. Mantena, S. Mutalik, H. Srinivasa, G.S. Subramanian, K.R. Prabhakar, K.R. Reddy, K.K. Srinivasan, M.K. Unnikrishnan

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 mg/kg doses on oral administration. Mechanistically, CD acts as an antioxidant as evidenced by its ability to scavenge DPPH and superoxide radicals. All the observed activities may be due to the presence of flavonoids, saponins and tannins as they are reported to possess a variety of biological activities. © 2005 Pharmaceutical Society of Japan.
Original languageEnglish
Pages (from-to)468-472
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume28
Issue number3
DOIs
Publication statusPublished - 2005

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Anti-Allergic Agents
Antipyretics
Hypoglycemic Agents
Pharmaceutical Societies
Tannins
Saponins
Plant Extracts
Flavonoids
Superoxides
Oral Administration
Japan
Antioxidants

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Mantena, S. K., Mutalik, S., Srinivasa, H., Subramanian, G. S., Prabhakar, K. R., Reddy, K. R., ... Unnikrishnan, M. K. (2005). Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus LINN. Biological and Pharmaceutical Bulletin, 28(3), 468-472. https://doi.org/10.1248/bpb.28.468
Mantena, S.K. ; Mutalik, S. ; Srinivasa, H. ; Subramanian, G.S. ; Prabhakar, K.R. ; Reddy, K.R. ; Srinivasan, K.K. ; Unnikrishnan, M.K. / Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus LINN. In: Biological and Pharmaceutical Bulletin. 2005 ; Vol. 28, No. 3. pp. 468-472.
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title = "Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus LINN",
abstract = "The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 mg/kg doses on oral administration. Mechanistically, CD acts as an antioxidant as evidenced by its ability to scavenge DPPH and superoxide radicals. All the observed activities may be due to the presence of flavonoids, saponins and tannins as they are reported to possess a variety of biological activities. {\circledC} 2005 Pharmaceutical Society of Japan.",
author = "S.K. Mantena and S. Mutalik and H. Srinivasa and G.S. Subramanian and K.R. Prabhakar and K.R. Reddy and K.K. Srinivasan and M.K. Unnikrishnan",
note = "Cited By :17 Export Date: 10 November 2017 CODEN: BPBLE Correspondence Address: Mantena, S.K.; Manipal College of Pharmaceutical Sciences, Manipal-576104, Karnataka, India; email: sudheerkumarm99@yahoo.com Chemicals/CAS: 1,1 diphenyl 2 picrylhydrazyl, 1898-66-4; glibenclamide, 10238-21-8; ketotifen fumarate, 34580-14-8; silymarin, 65666-07-1; superoxide, 11062-77-4; Analgesics, Non-Narcotic; Anti-Allergic Agents; Hypoglycemic Agents; Plant Extracts; Water, 7732-18-5 References: Inam-ul-haque, (1989) J. Chem. Soc. Pakistan, 11, pp. 80-81; McDowall, F.H., Mortan, I.D., McDowell, A.K.R., (1947) New Zealand J. Sci. Tech., A28, pp. 305-307; De Ruiz, R.E.L., Fusco, M., Sosa, A., Ruiz, S.O., (1994) Fitoterpia, 65, pp. 181-182; Prabhakar, K.R., Srinivasan, K.K., Padma, G.M.R., (2002) Pharm. Biol., 40, pp. 490-493; Gupta, S.S., Tripathi, R.M., (1973) Aspects. Allergy. Applied. Immunol., 6, pp. 93-99; Salil, S., Gupta, P.P., Rajendra, P., Dixit, K.S., Palit, G., Ali, B., Gopal, M., Saxena, R.C., (1999) Indian J. Physiol. Phamacol., 43, pp. 235-241; Rao, R.R., Babu, R.M., Rao, M.R.V., Babu, M.G.V., (1997) Indian Drugs, 34, pp. 690-693; Mutalik, S., Paridhavi, K., Mallikarjuna Rao, C., Udupa, N., (2003) Indian J. Pharmacol., 5, pp. 312-315; Grover, J.K., Vats, V., Rathi, S.S., Dawar, R., (2001) J. Ethnopharmacol., 76, pp. 233-238; Sedlak, J., Lindsay, R.H., (1968) Analytical Biochem., 25, pp. 192-205; Ohkawa, H., Ohishi, N., Yagi, K., (1979) Analytical Biochem., 95, pp. 351-358; Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., (1951) J. Biol. Chem., 193, pp. 265-275; Mantena, S.K., Jagadish, P., Badduri, S.R., Siripurapu, K.B., Unnikrishnan, M.K., (2003) Nahrung, 2, pp. 126-131; Sreejayan, N., Rao, M.N.A., (1990) Fitoterpia, 62, pp. 344-346; Schwartz, L.B., (1994) Curr. Opin. Immunol., 6, pp. 91-94; Rajanarayana, K., Sripal Reddy, M., Chaluvadi, M.R., Krishna, D.R., (2001) Indian J. Pharmacol., 33, pp. 2-16; Brasseur, T., (1989) J. Pharm. Belg., pp. 235-241; Vimala, R., Nagarajan, S., Alam, Susant, J., (1990) Indian J. Exptl. Biol., 35, pp. 1310-1314; Brzezinska, S.E., (2001) J. Physiol. Pharmacol., 52, pp. 275-284; Pari, L., Ramakrishnan, R., Venkateshwaran, S., (2001) J. Pharm. Pharmacol., 53, pp. 1139-1143; Achrekar, S., Kaklij, G.S., Pote, M.S., Kelkar, S.M., (1991) In Vivo, 5, pp. 143-147; Yanardag, R., Colak, H., (1998) Pharm. Pharmacol. Commun., 4, pp. 309-311; Bajaj, S., Srinivasan, B.P., (1999) Indian J. Pharmacol., 31, pp. 138-141; Cai, L., Kang, Y.J., (2001) Cardio. Toxicol., 1, pp. 181-193; Kumari, K., Augusti, K.T., (2002) Indian J. Exptl. Biol., 40, pp. 1005-1009; Mishra, B., Priyadarsini, K.I., Mantena, S.K., Unnikrishnan, M.K., Mohan, H., (2003) Bioorg. Med. Chem., 11, pp. 2677-2685",
year = "2005",
doi = "10.1248/bpb.28.468",
language = "English",
volume = "28",
pages = "468--472",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
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}

Mantena, SK, Mutalik, S, Srinivasa, H, Subramanian, GS, Prabhakar, KR, Reddy, KR, Srinivasan, KK & Unnikrishnan, MK 2005, 'Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus LINN', Biological and Pharmaceutical Bulletin, vol. 28, no. 3, pp. 468-472. https://doi.org/10.1248/bpb.28.468

Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus LINN. / Mantena, S.K.; Mutalik, S.; Srinivasa, H.; Subramanian, G.S.; Prabhakar, K.R.; Reddy, K.R.; Srinivasan, K.K.; Unnikrishnan, M.K.

In: Biological and Pharmaceutical Bulletin, Vol. 28, No. 3, 2005, p. 468-472.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus LINN

AU - Mantena, S.K.

AU - Mutalik, S.

AU - Srinivasa, H.

AU - Subramanian, G.S.

AU - Prabhakar, K.R.

AU - Reddy, K.R.

AU - Srinivasan, K.K.

AU - Unnikrishnan, M.K.

N1 - Cited By :17 Export Date: 10 November 2017 CODEN: BPBLE Correspondence Address: Mantena, S.K.; Manipal College of Pharmaceutical Sciences, Manipal-576104, Karnataka, India; email: sudheerkumarm99@yahoo.com Chemicals/CAS: 1,1 diphenyl 2 picrylhydrazyl, 1898-66-4; glibenclamide, 10238-21-8; ketotifen fumarate, 34580-14-8; silymarin, 65666-07-1; superoxide, 11062-77-4; Analgesics, Non-Narcotic; Anti-Allergic Agents; Hypoglycemic Agents; Plant Extracts; Water, 7732-18-5 References: Inam-ul-haque, (1989) J. Chem. Soc. Pakistan, 11, pp. 80-81; McDowall, F.H., Mortan, I.D., McDowell, A.K.R., (1947) New Zealand J. Sci. Tech., A28, pp. 305-307; De Ruiz, R.E.L., Fusco, M., Sosa, A., Ruiz, S.O., (1994) Fitoterpia, 65, pp. 181-182; Prabhakar, K.R., Srinivasan, K.K., Padma, G.M.R., (2002) Pharm. Biol., 40, pp. 490-493; Gupta, S.S., Tripathi, R.M., (1973) Aspects. Allergy. Applied. Immunol., 6, pp. 93-99; Salil, S., Gupta, P.P., Rajendra, P., Dixit, K.S., Palit, G., Ali, B., Gopal, M., Saxena, R.C., (1999) Indian J. Physiol. Phamacol., 43, pp. 235-241; Rao, R.R., Babu, R.M., Rao, M.R.V., Babu, M.G.V., (1997) Indian Drugs, 34, pp. 690-693; Mutalik, S., Paridhavi, K., Mallikarjuna Rao, C., Udupa, N., (2003) Indian J. Pharmacol., 5, pp. 312-315; Grover, J.K., Vats, V., Rathi, S.S., Dawar, R., (2001) J. Ethnopharmacol., 76, pp. 233-238; Sedlak, J., Lindsay, R.H., (1968) Analytical Biochem., 25, pp. 192-205; Ohkawa, H., Ohishi, N., Yagi, K., (1979) Analytical Biochem., 95, pp. 351-358; Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., (1951) J. Biol. Chem., 193, pp. 265-275; Mantena, S.K., Jagadish, P., Badduri, S.R., Siripurapu, K.B., Unnikrishnan, M.K., (2003) Nahrung, 2, pp. 126-131; Sreejayan, N., Rao, M.N.A., (1990) Fitoterpia, 62, pp. 344-346; Schwartz, L.B., (1994) Curr. Opin. Immunol., 6, pp. 91-94; Rajanarayana, K., Sripal Reddy, M., Chaluvadi, M.R., Krishna, D.R., (2001) Indian J. Pharmacol., 33, pp. 2-16; Brasseur, T., (1989) J. Pharm. Belg., pp. 235-241; Vimala, R., Nagarajan, S., Alam, Susant, J., (1990) Indian J. Exptl. Biol., 35, pp. 1310-1314; Brzezinska, S.E., (2001) J. Physiol. Pharmacol., 52, pp. 275-284; Pari, L., Ramakrishnan, R., Venkateshwaran, S., (2001) J. Pharm. Pharmacol., 53, pp. 1139-1143; Achrekar, S., Kaklij, G.S., Pote, M.S., Kelkar, S.M., (1991) In Vivo, 5, pp. 143-147; Yanardag, R., Colak, H., (1998) Pharm. Pharmacol. Commun., 4, pp. 309-311; Bajaj, S., Srinivasan, B.P., (1999) Indian J. Pharmacol., 31, pp. 138-141; Cai, L., Kang, Y.J., (2001) Cardio. Toxicol., 1, pp. 181-193; Kumari, K., Augusti, K.T., (2002) Indian J. Exptl. Biol., 40, pp. 1005-1009; Mishra, B., Priyadarsini, K.I., Mantena, S.K., Unnikrishnan, M.K., Mohan, H., (2003) Bioorg. Med. Chem., 11, pp. 2677-2685

PY - 2005

Y1 - 2005

N2 - The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 mg/kg doses on oral administration. Mechanistically, CD acts as an antioxidant as evidenced by its ability to scavenge DPPH and superoxide radicals. All the observed activities may be due to the presence of flavonoids, saponins and tannins as they are reported to possess a variety of biological activities. © 2005 Pharmaceutical Society of Japan.

AB - The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 mg/kg doses on oral administration. Mechanistically, CD acts as an antioxidant as evidenced by its ability to scavenge DPPH and superoxide radicals. All the observed activities may be due to the presence of flavonoids, saponins and tannins as they are reported to possess a variety of biological activities. © 2005 Pharmaceutical Society of Japan.

U2 - 10.1248/bpb.28.468

DO - 10.1248/bpb.28.468

M3 - Article

VL - 28

SP - 468

EP - 472

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 3

ER -