Antiamnesic and neuroprotective effects of low dose of Ramipril and Losartan in scopolamine-induced amnesia model of dementia

Debasree Deb, Veena Nayak, K. L. Bairy, K. G. Mohandas Rao, Jeevan Shetty, Mangala V. Hegde, Salini S. Koshy

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2 Citations (Scopus)

Abstract

To investigate the potential role of ramipril and losartan in preventing scopolamine-induced memory impairment in rats. Memory impairment was induced in male Wistar rats by administration of scopolamine (1 mg/kg intraperitoneally). Rats received oral doses of ramipril (0.225 mg/kg) and losartan (2.25 mg/kg) for a period of four weeks. Passive avoidance paradigm was used to assess learning and memory. Biochemical estimations of malondialdehyde, glutathione transferase, protein thiols, and histological analysis of hippocampal morphology were performed to estimate the degree of oxidative stress and neuronal degeneration. Pre-treatment with ramipril and losartan reversed scopolamine-induced memory impairment, oxidative stress and hippocampal degeneration which were evident by the findings from behavioral, biochemical and histological studies.

Original languageEnglish
Pages (from-to)1174-1182
Number of pages9
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume4
Issue number1
Publication statusPublished - 01-01-2013

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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