Antiapoptotic Bcl-2 protein as a potential target for cancer therapy: A mini review

Hitesh Jagani, Narayanan Kasinathan, Sreenivasa Reddy Meka, Josyula Venkata Rao

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Bcl-2, an antiapoptotic protein, is considered as a potential target in cancer treatment since its oncogenic potential has been proven and is well documented. Antisense technology and RNA interference (RNAi) have been used to reduce the expression of the Bcl-2 gene in many types of cancer cells and are effective as adjuvant therapy along with the chemotherapeutic agents. The lack of appropriate delivery systems is considered to be the main hurdle associated with the RNAi. In this review, we discuss the antiapoptotic Bcl-2 protein, its oncogenic potential, and various approaches utilized to target Bcl-2 including suitable delivery systems employed for successful delivery of siRNA.

Original languageEnglish
Pages (from-to)1212-1221
Number of pages10
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume44
Issue number5
DOIs
Publication statusPublished - 03-07-2016

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science

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