Antibacterial activity of ciprofloxacin-beta-cyclodextrin complex and its efficacy in dental implants.

K. S. Aithal, N. Udupa, B. R. Varma, R. Kurian

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Ciprofloxacin forms an inclusion complex with beta-cyclodextrin. The in vitro antibacterial activity of ciprofloxacin on E. coli and Staphylococcus aureus was found better on complexation. The complex was found very effective as a local antibacterial agent when used in dental implants. Significant reduction in the gingival index, probing pocket depth and microbial growth coupled with gain in attachment at the test site compared to control on the 14th day was observed when the implants containing 2.0 mg of the complex equivalent to 0.4 mg of ciprofloxacin was used in clinical trials.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalIndian journal of dental research : official publication of Indian Society for Dental Research
Issue number4
Publication statusPublished - 10-1995


All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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