Antibacterial activity of ciprofloxacin-beta-cyclodextrin complex and its efficacy in dental implants.

K. S. Aithal, N. Udupa, B. R. Varma, R. Kurian

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Ciprofloxacin forms an inclusion complex with beta-cyclodextrin. The in vitro antibacterial activity of ciprofloxacin on E. coli and Staphylococcus aureus was found better on complexation. The complex was found very effective as a local antibacterial agent when used in dental implants. Significant reduction in the gingival index, probing pocket depth and microbial growth coupled with gain in attachment at the test site compared to control on the 14th day was observed when the implants containing 2.0 mg of the complex equivalent to 0.4 mg of ciprofloxacin was used in clinical trials.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalIndian journal of dental research : official publication of Indian Society for Dental Research
Volume6
Issue number4
Publication statusPublished - 10-1995

Fingerprint

Dental Implants
Ciprofloxacin
Periodontal Index
Staphylococcus aureus
Clinical Trials
Escherichia coli
Anti-Bacterial Agents
Growth
betadex

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

@article{db934a3ccdda482bbbe1a1fb771a6017,
title = "Antibacterial activity of ciprofloxacin-beta-cyclodextrin complex and its efficacy in dental implants.",
abstract = "Ciprofloxacin forms an inclusion complex with beta-cyclodextrin. The in vitro antibacterial activity of ciprofloxacin on E. coli and Staphylococcus aureus was found better on complexation. The complex was found very effective as a local antibacterial agent when used in dental implants. Significant reduction in the gingival index, probing pocket depth and microbial growth coupled with gain in attachment at the test site compared to control on the 14th day was observed when the implants containing 2.0 mg of the complex equivalent to 0.4 mg of ciprofloxacin was used in clinical trials.",
author = "Aithal, {K. S.} and N. Udupa and Varma, {B. R.} and R. Kurian",
year = "1995",
month = "10",
language = "English",
volume = "6",
pages = "123--128",
journal = "Indian Journal of Dental Research",
issn = "0970-9290",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "4",

}

TY - JOUR

T1 - Antibacterial activity of ciprofloxacin-beta-cyclodextrin complex and its efficacy in dental implants.

AU - Aithal, K. S.

AU - Udupa, N.

AU - Varma, B. R.

AU - Kurian, R.

PY - 1995/10

Y1 - 1995/10

N2 - Ciprofloxacin forms an inclusion complex with beta-cyclodextrin. The in vitro antibacterial activity of ciprofloxacin on E. coli and Staphylococcus aureus was found better on complexation. The complex was found very effective as a local antibacterial agent when used in dental implants. Significant reduction in the gingival index, probing pocket depth and microbial growth coupled with gain in attachment at the test site compared to control on the 14th day was observed when the implants containing 2.0 mg of the complex equivalent to 0.4 mg of ciprofloxacin was used in clinical trials.

AB - Ciprofloxacin forms an inclusion complex with beta-cyclodextrin. The in vitro antibacterial activity of ciprofloxacin on E. coli and Staphylococcus aureus was found better on complexation. The complex was found very effective as a local antibacterial agent when used in dental implants. Significant reduction in the gingival index, probing pocket depth and microbial growth coupled with gain in attachment at the test site compared to control on the 14th day was observed when the implants containing 2.0 mg of the complex equivalent to 0.4 mg of ciprofloxacin was used in clinical trials.

UR - http://www.scopus.com/inward/record.url?scp=0029380511&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029380511&partnerID=8YFLogxK

M3 - Article

VL - 6

SP - 123

EP - 128

JO - Indian Journal of Dental Research

JF - Indian Journal of Dental Research

SN - 0970-9290

IS - 4

ER -